In this article, we will explore how Diphenylamine (C12H11N) affects the health of workers in chemical production environments. Learn about the potential risks and preventive measures to protect everyone’s health and safety.
1. What is Diphenylamine?
Diphenylamine is an organic compound with the chemical formula C12H11N. Known by various names such as diphenylamine or dianilin, this compound is often used in industrial and chemical applications.
Structurally, diphenylamine is a derivative of aniline, an organic compound containing an amino group (-NH2). Specifically, it consists of two phenyl groups connected through a nitrogen atom, forming a simple yet distinct molecular structure.
| No. | Chemical Name in Vietnamese | Chemical Name in English | HS Code | CAS Number | Chemical Formula |
| 1. | Diphenylamin | Diphenylamine | 29214400 | 122-39-4 | C12H11N |
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2. Where does Diphenylamine originate from in the production process?
In the production process, diphenylamine is synthesized from the basic raw materials aniline and nitrobenzene. Aniline, an important organic compound, is an aromatic amine with the chemical formula C6H5NH2. This is the main raw material in the production of diphenylamine. Aniline is usually produced from benzene through nitration and nitro reduction with hydrogen using a suitable catalyst.
After obtaining aniline, the next synthesis step is the Friedel-Crafts reaction between aniline and nitrobenzene. Nitrobenzene is an organic compound with the formula C6H5NO2, used as a raw material in the synthesis of diphenylamine. The Friedel-Crafts reaction is a chemical reaction in organic chemistry where a proton from a Lewis acid (in this case, aniline) attacks the electron-rich region on the benzene system of nitrobenzene.

3. Industries that use Diphenylamine in production
In the chemical industry, Diphenylamine (DPA) is widely used in the production of several important products. One of the main industries where DPA is applied is in the production of rubber compounds. DPA is often used as a stabilizer to preserve rubber, helping to enhance the product’s lifespan and elasticity. The use of DPA in the rubber manufacturing industry plays an important role in improving the quality and performance of final rubber products.
Diphenylamine is also used in the fertilizer production industry. DPA is often used to produce nitrogen fertilizers, supplementing the preservation and maintenance of fertilizer quality. The presence of DPA helps prevent the decomposition and oxidation of components in the fertilizer, thereby maintaining the product’s quality over a long period.
In addition, DPA also plays an important role in the corrosion inhibitor production industry. Corrosion inhibitors are widely used in many industries such as the petrochemical industry, the automotive industry, and the production of metal products. Diphenylamine is often used as a key component to create types of corrosion inhibitors, helping to protect the surface of metal materials from corrosion caused by environmental or chemical impacts.
4. How does Diphenylamine affect workers
Diphenylamine (DPA) is used in many different industries, but exposure to it can cause serious health problems for workers. Here, we will analyze the effects of Diphenylamine on workers’ health:
- Respiratory toxicity: Diphenylamine can cause respiratory irritation, leading to symptoms such as coughing, difficulty breathing, runny nose, and sore throat. If exposed to high concentrations for a long time, it can cause more serious lung problems, such as bronchitis and pulmonary edema.
- Skin irritation: Diphenylamine can cause skin irritation, leading to rashes, redness, itching, and peeling. Prolonged or repeated skin contact can cause dermatitis and make the skin more sensitive.
- Poisoning: Ingesting Diphenylamine can cause poisoning, leading to symptoms of nausea, vomiting, dizziness, headache, and drowsiness. In severe cases, Diphenylamine poisoning can lead to seizures, coma, and even death.
- Cancer risk: Some studies suggest that Diphenylamine may be linked to causing bladder cancer in workers exposed to it for a long time. However, more research is needed to confirm this link.
5. Permissible safe concentration of Diphenylamine for human exposure
Diphenylamine (DPA) is known for some adverse effects on human health if exposed at high concentrations. Therefore, establishing standards for the permissible safe concentration (PSC) of Diphenylamine is very necessary to protect the health of workers in the working environment and the general public.
Currently, the world’s leading health and occupational safety organizations have issued recommendations on the PSC of Diphenylamine. In Vietnam, the Ministry of Health and the Department of Occupational Safety and Health (DOSH) issue regulations on the maximum permissible concentrations of toxic substances in the working environment, including Diphenylamine.
The PSC of Diphenylamine may depend on factors such as:
- Route of exposure: The PSC may differ depending on how humans are exposed to Diphenylamine. The PSC via the respiratory route is usually lower than the PSC via the skin or digestive tract.
- Exposure time: The PSC is divided into a short-term exposure limit (STEL) and a long-term exposure limit (LTEL). The STEL is the maximum concentration of Diphenylamine allowed for exposure over a short period (usually 15 minutes) without causing acute health effects. The LTEL is the average concentration of Diphenylamine allowed for exposure during a workday (usually 8 hours) over a long period without harming health.
- Health status: The PSC may need to be adjusted for individuals with underlying medical conditions or poor health.
You should refer to the chemical safety guidance documents issued by the Ministry of Health and the DOSH to know the exact PSC of Diphenylamine in Vietnam. In addition, applying appropriate engineering controls and personal protective equipment (PPE) is also necessary to minimize the risk of exposure to Diphenylamine and protect workers’ health.

At a basic level, if working in an industrial environment, it is important to adhere to safety standards and limit exposure to Diphenylamine. Organizations like the Occupational Safety and Health Administration (OSHA) in the United States provide guidelines and safety principles to protect workers from the negative impacts of chemical substances.
6. Measures to minimize the effects of Diphenylamine on workers’ health
Measures to minimize the effects of Diphenylamine on workers’ health are an important part of protecting employees’ health during the production and use of this chemical. To ensure worker safety, measures need to be implemented from the planning and operational stages to regular inspection and monitoring.
First, it is necessary to conduct risk assessments and identify control measures to minimize exposure to Diphenylamine. This includes using personal protective equipment such as masks, gloves, and chemical-resistant clothing. At the same time, it is necessary to establish safe work procedures and train employees on how to use chemicals safely and effectively.
Using safe equipment and technology also plays an important role in minimizing exposure to Diphenylamine. Ventilation and toxic substance extraction systems must be properly installed and maintained to remove fumes, chemical vapors, and other harmful agents from the work environment.
In addition, monitoring workers’ health is also an important part of the mitigation measures. Occupational health programs should be implemented to monitor employees’ health, detect early signs of abnormalities, and provide appropriate treatment if needed.
Occupational safety training: Workers need to be trained and educated about the risks and safety measures when working with this type of chemical. This training should be provided periodically and frequently to ensure understanding and proper compliance with safety rules.
Periodically organize workplace environment monitoring in factories and enterprises, collect and analyze factors harmful to workers, and from there, adjust to reduce hazard levels to prevent occupational diseases for them.
7. Nationwide workplace environment monitoring center
Nam Viet’s workplace environment monitoring center is a professional unit for monitoring and measuring the quality of the working environment in all provinces and cities in Vietnam. With a team of experienced monitoring specialists, the center uses modern measuring equipment, ensuring accuracy and reliability.
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In addition to providing monitoring services, the center also supports clients in planning, handling, and tracking workplace environment issues. With the motto “the customer is the center,” the center focuses on customer satisfaction, meets all customer needs, and is committed to providing the best solutions for businesses.
With investment in techniques, technology, and human resources, Nam Viet’s monitoring center has become one of the reputable units in the field of workplace environment monitoring in Ho Chi Minh City with the following objectives:
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- Coming to the Nam Viet Environmental Monitoring team, your company will receive professional service from experts in the monitoring field. At the same time, you will get the best cost incentives.
8. Workplace environment monitoring quotation
To help businesses carry out workplace environment monitoring professionally and effectively, Nam Viet provides customers with a quality and reasonably priced quotation for workplace environment monitoring services.
- Our monitoring quotation provides detailed information on the prices of the monitoring services we offer. This includes costs related to travel, measurement, analysis, and reporting of results. Customers can be completely assured of the accuracy and reliability of the monitoring result reports we provide.
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