Does the chemical Epibromo Hydrin (C3H5OBr) affect the health of employees working in production plants? This article will provide an overview of the impact of this substance and how to protect workers’ health in an industrial environment.
1. What is Epibromo hydrin?
Epibromhydrin (also known as 2-bromopropan-1-ol) is an organic compound belonging to the halohydrin class, formed from bromine and an epoxy group bonded to a propanol molecule. Epibromhydrin is a colorless to slightly yellow liquid, with a slight odor similar to chloroform.
Epibromhydrin is flammable and slightly toxic. In liquid form, it can cause skin and eye irritation. When inhaled, it can cause respiratory irritation. Therefore, caution must be exercised when handling epibromhydrin and chemical safety regulations must always be followed.
| No. | Chemical name in Vietnamese | Chemical name in English | HS Code | CAS Number | Chemical Formula |
| 1. | Epibrom hydrin | Epibromo hydrin | 29109000 | 3132-64-7 | C3H5Obr |
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2. Where does Epibromo hydrin originate from in the production process?
Epibromhydrin (EB) is an unwanted byproduct in the production of glycerin dichlorohydrin (GDICH), an important intermediate compound for producing epoxy resins. The GDICH production process typically uses propylene as a raw material, reacting with chlorine and water under an acid catalyst. During this reaction process, besides GDICH as the main product, side reactions also occur that create EB.
The formation of EB is believed to be due to the rearrangement of atoms within the propylene molecule under the influence of the acid catalyst. Specifically, the double bond between carbon atoms in propylene is broken, and chlorine and bromine atoms (which may come from impurities in the reaction mixture) bond to these carbons. This rearrangement leads to the molecular structure of EB, which is different from the desired structure of GDICH.
Depending on the reaction conditions (temperature, reaction time, catalyst concentration), the proportion of EB in the final product can vary. In general, higher reaction temperatures and longer reaction times will favor the formation of this unwanted product. Additionally, the use of a strong acid catalyst can also increase the amount of EB formed.

3. Industries that use Epibromo hydrin in production
Epibromohydrin (EB) is a versatile organic compound found in many different industries. Here are some typical application areas for EB:
- Epoxy resin production: EB serves as an essential intermediate in the production of epoxy resins, a type of thermosetting resin widely used in applications requiring high strength, heat resistance, and corrosion resistance. Epoxy resins are used in paint coatings, adhesives, composite materials, and electronic components.
- Pharmaceutical production: EB is a raw material in the production of glycerol glycidyl ether (glycidol), an important intermediate compound for preparing sedatives, anticancer drugs, and antibiotics.
- Flame retardant production: EB is used to produce brominated flame retardants, which help prevent the spread of fire in materials such as fabrics, plastics, and rubber.
- Surfactant production: EB is a component in the production of certain surfactants, used in detergents, cosmetics, and other personal care products.
- Production of other compounds: EB is also a raw material for the production of many other organic compounds, such as glycol derivatives and amine compounds.
4. How does Epibromo hydrin affect workers?
Epibromhydrin is a dangerous chemical compound that, if exposed to for long periods or without appropriate preventive measures, can cause many adverse health effects for workers. Here are some of the effects of Epibromhydrin on workers:
- Respiratory disorders: When inhaling Epibromhydrin vapor, workers may experience respiratory irritation symptoms such as coughing, difficulty breathing, sore throat, and runny nose. In severe cases, it can lead to pulmonary edema, bronchitis, and other respiratory problems.
- Skin and eye irritation: Direct contact of Epibromhydrin with the skin or eyes can cause irritation, redness, and burning. If contact is prolonged and untreated, it can lead to dermatitis, skin ulcers, and serious eye damage.
- Neurological effects: Epibromhydrin can cause symptoms affecting the nervous system such as headache, dizziness, nausea, fatigue, sleep disorders, and difficulty concentrating. In cases of exposure to high concentrations, it can lead to seizures, coma, and nerve damage.
- Cancer risk: Some studies suggest that Epibromhydrin may be linked to causing cancer. Currently, evidence on this issue is still being further researched, but workers should limit exposure to Epibromhydrin to minimize the risk of disease.
- Reproductive problems: Epibromhydrin is suspected of potentially causing adverse effects on the reproductive systems of both men and women. Exposure to Epibromhydrin can lead to menstrual disorders, reduced sperm quality, and an increased risk of miscarriage.
To protect workers’ health, businesses need to strictly implement occupational safety regulations when using Epibrom hydrin. This includes providing appropriate personal protective equipment, training workers on the risks of Epibrom hydrin, and implementing engineering controls to minimize exposure to this chemical.
5. Permissible safe concentration of Epibromo hydrin for human exposure
Epibromo hydrin (EB) is a volatile organic compound used in the production of epoxy resins and other materials. However, EB is also classified as a toxic substance, which can cause irritation to the skin, eyes, and respiratory system. Therefore, controlling the concentration of EB in the working environment is very important to ensure the safety of workers’ health.
According to reputable occupational health organizations, such as the International Labour Organization (ILO) and the US National Institute for Occupational Safety and Health (NIOSH), the permissible exposure limit (PEL) for Epibromo hydrin is recommended as:
- Time-weighted average (TWA) concentration: 10 ppm (parts per million) for an 8-hour workday
- Short-term exposure limit (STEL): 25 ppm for a duration not exceeding 15 minutes, with a maximum of 4 times per workday, at least 1 hour apart each time.
Compliance with these limits helps minimize the risk of exposure to EB and its adverse health effects. In addition, other technical and administrative control measures also need to be implemented to ensure safety, such as:
- Ventilation: Maintain an effective ventilation system to remove EB from the work area.
- Personal Protective Equipment (PPE): Provide workers with appropriate protective equipment, such as gloves, masks, and goggles to limit skin, eye, and respiratory contact.
- Training program: Implement a training program to help workers recognize the risks of EB, preventive measures, and what to do in case of an emergency.
By adhering to the permissible concentration regulations and implementing other control measures, businesses can create a safer working environment for workers exposed to Epibromo hydrin.

At a basic level, if working in an industrial environment, it is important to comply with safety standards and limit exposure to Epibrom hydrin. Organizations like the Occupational Safety and Health Administration (OSHA) in the United States provide guidelines and safety principles to protect workers from the negative impacts of chemical substances.
6. Measures to minimize the effects of Epibromo hydrin on workers’ health
Epibromo hydrin is a hazardous chemical, so applying measures to minimize its effects on workers’ health is essential. Here are some effective methods:
Engineering Controls:
- Ventilation system: Equip local exhaust ventilation at the workplace to draw Epibromo hydrin vapor away from the workers’ breathing zone.
- Equipment control: Regularly maintain and check for leaks in equipment containing or using Epibromo hydrin to prevent spills.
- Chemical substitution: If possible, safer chemical alternatives to Epibromo hydrin should be sought.
Personal Protective Measures:
- Provide workers with appropriate personal protective equipment, including: protective clothing, chemical-resistant goggles, respirators suitable for the concentration of Epibromo hydrin, accompanied by appropriate filters.
- Ensure workers are trained on how to use and maintain personal protective equipment correctly.
Administrative Controls:
- Establish and adhere to safe work procedures related to the use of Epibromo hydrin.
- Minimize the number of workers directly exposed to Epibromo hydrin.
- Provide regular training programs for workers on the hazards of Epibromo hydrin and the necessary preventive measures.
- Conduct periodic health check-ups for workers exposed to Epibromo hydrin to promptly detect signs of health effects.
Personal Hygiene Practices:
- Require workers to wash their hands with soap regularly, especially before eating, drinking, smoking, and after removing protective equipment.
- Do not eat, drink, or smoke in work areas where Epibromo hydrin is present.
- Provide separate shower rooms and changing rooms to prevent carrying Epibromo hydrin outside the work area.
By strictly implementing the above measures, businesses can significantly reduce the health risks for workers who must come into contact with Epibromo hydrin.
Occupational safety training: Workers need to be trained and educated about the risks and safety measures when working with this type of chemical. This training needs to be provided periodically and regularly to ensure understanding and proper compliance with safety rules.
Periodically organize workplace environment monitoring in factories and enterprises, collect and analyze harmful factors for workers, thereby adjusting to reduce the hazard level to prevent occupational diseases for them.
7. Nationwide workplace environment monitoring center
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8. Quotation for workplace environment monitoring
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