Ethyl formate, also known as ethyl acetate, is an organic compound often used in the production of paints, solvents, and flavorings. However, exposure to this chemical in the work environment can lead to many serious health risks for workers. This article will delve into a detailed analysis of the negative health effects of ethyl formate on human health, while also proposing necessary preventive measures to ensure occupational safety in production environments using this chemical.
1. What is Ethyl formate?
Ethyl formate is an ester formed from the reaction between ethanol (ethyl alcohol) and formic acid (the simplest acetic acid). The chemical formula of ethyl formate is C3H6O2, corresponding to a molecular weight of 74.08 g/mol. In its standard state, ethyl formate is a colorless liquid with a characteristic aromatic odor. In addition, ethyl formate has some other notable physical properties such as:
- Flammable: Ethyl formate is a very flammable substance, care must be taken when using and storing it.
- Soluble in water: Ethyl formate is soluble in water.
- Low boiling point: Ethyl formate has a boiling point of 54.3 °C, easily evaporating under normal environmental conditions.
However, it should be noted that ethyl formate can be slowly decomposed by water into formic acid (which is corrosive) and ethanol (ethyl alcohol). In addition, inhaling ethyl formate vapor can cause mild irritation to the eyes and nasal mucosa. Therefore, ethyl formate should be used in a well-ventilated environment with appropriate protective equipment.
| No. | Chemical name in Vietnamese | Chemical name in English | HS Code | CAS Number | Chemical Formula |
| 1. | Etyl format | Ethyl formate | 29151300 | 109-94-4 | C3H6O2 |
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2. Where does Ethyl formate originate from in the production process?
Ethyl formate (ethylic formate) can be formed during the production process in several different ways. In this section, we will delve into the main sources of ethyl formate:
- Ethanol fermentation process: Ethyl formate is a natural byproduct in the ethanol fermentation process from sugar or starch. It is created by yeast enzymes involved in the fermentation process. The amount of ethyl formate produced usually depends on factors such as the yeast strain, fermentation conditions (temperature, pH), and raw materials.
- Ethanol production process by chemical methods: In addition to fermentation, ethyl formate can also be created as a byproduct in the process of producing ethanol by chemical synthesis from ethylene. Depending on the specific production process, ethyl formate may be removed or isolated in the downstream processing stages.
- Reaction between ethanol and formic acid: Ethyl formate can be formed through the reaction between ethanol and formic acid, usually catalyzed by a strong inorganic acid. This reaction is rarely used for the commercial production of ethyl formate, but it can occur during the production of other products that contain both ethanol and formic acid.

3. Industries that use Ethyl formate in production
Ethyl formate is a versatile ester with many applications in various manufacturing industries. Here are some typical fields that use Ethyl formate:
- Food and beverages: Ethyl formate plays an important role in the food and beverage industry with its function of creating characteristic flavors. The aroma of Ethyl formate is reminiscent of rum and raspberries, helping to add appeal to products such as confectionery, soft drinks, ice cream, and even flavorings for alcohol.
- Pharmaceuticals: Ethyl formate is used as an additive in the production of drugs and vitamins. In addition, the antibacterial properties of Ethyl formate are also effective in sterilizing tobacco, grains, and grain products such as popcorn.
- Cosmetics and personal care: Ethyl formate is present in the ingredients of some skin care products, especially mild cleansers.
4. How does Ethyl formate affect workers?
Ethyl formate, if inhaled at high concentrations or for long periods, can cause serious health problems for workers. Common symptoms include:
- Respiratory irritation: Ethyl formate causes irritation to the nose, throat, and lungs. Workers may experience coughing, difficulty breathing, runny nose, and sore throat. In severe cases, it can lead to pulmonary edema (accumulation of fluid in the lungs).
- Skin and eye irritation: direct contact with liquid ethyl formate or vapor can cause skin and eye irritation. Symptoms include redness, itching, burning, and watery eyes.
- Central nervous system: If exposed to very high concentrations of ethyl formate, workers may experience headaches, dizziness, nausea, fatigue, and loss of consciousness. In severe cases, it can lead to nerve damage.
- Cancer: Some studies suggest that long-term exposure to ethyl formate may increase the risk of certain cancers. However, more research is needed to confirm this link.
5. Permissible safe concentration of Ethyl formate for human exposure
Ethyl formate (ethylic formate) is an ester found in many foods and beverages, so human exposure is unavoidable. However, the concentration of Ethyl formate in the air can affect health.
According to reputable health safety organizations, no official Occupational Exposure Limit (OEL) has been established for Ethyl formate. However, some recommendations on the maximum concentration in the air have been made:
- ACGIH (American Conference of Governmental Industrial Hygienists): The recommended Time-Weighted Average (TWA) exposure limit is 400 ppm for 8 hours/day and 40 hours/week.
- DFG (Deutsche Forschungsgemeinschaft): Recommends a maximum workplace concentration of 100 ppm.

On a basic level, if working in an industrial environment, adhering to safety standards and limiting exposure to Ethyl formate is important. Organizations like the Occupational Safety and Health Administration (OSHA) in the United States provide guidelines and safety principles to protect workers from the negative impacts of chemical substances.
6. Measures to mitigate the effects of Ethyl formate on worker health
Ethyl formate, although widely used in many industries, still poses potential health risks to workers if appropriate preventive measures are not in place. Here are some effective methods to minimize these negative impacts:
Engineering controls:
- Ventilation: Maintain a well-functioning ventilation system in the work area to remove Ethyl formate from the surrounding environment.
- Protective equipment: Provide workers with appropriate personal protective equipment (PPE), such as respirators with organic vapor cartridges, safety goggles, and chemical-resistant gloves.
- Material substitution: If possible, alternative materials that are less toxic than Ethyl formate should be sought to minimize exposure risk.
2. Safe handling practices:
- Safety training: Provide a comprehensive safety training program for workers on the hazardous properties of Ethyl formate, necessary preventive measures, and the correct use of personal protective equipment (PPE).
- Warning signs: Mark areas containing Ethyl formate with clear warning signs about the associated risks.
- Personal hygiene practices: Require workers to wash their hands frequently, especially before eating, smoking, or after contact with Ethyl formate.
- No eating or drinking in the work area: Designate separate eating areas to avoid accidental ingestion of Ethyl formate.
3. Health monitoring:
- Periodic health check-ups: Implement periodic health check-up programs for workers regularly exposed to Ethyl formate to detect any unusual health signs early.
By strictly implementing the measures mentioned above, businesses can significantly reduce the health risks associated with Ethyl formate, ensuring worker safety and maintaining a healthy work environment.
Occupational safety training: Workers need to be trained and educated on the risks and safety measures when working with this type of chemical. This training needs to be provided periodically and regularly to ensure understanding and compliance with safety rules.
Periodically organize workplace environment monitoring in factories and enterprises, collect and analyze factors harmful to workers, thereby adjusting to reduce hazard levels to prevent occupational diseases for them.
7. Nationwide workplace environment monitoring center
Nam Viet’s workplace environment monitoring center is a professional unit specializing in monitoring and measuring the quality of the working environment across all provinces in Vietnam. With a team of experienced monitoring specialists, the center uses modern measuring equipment, ensuring accuracy and reliability.
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In addition to providing monitoring services, the center also supports customers in planning, handling, and tracking workplace environment issues. With the motto “the customer is the center”, the center focuses on customer satisfaction, meets all customer needs, and commits to providing the best solutions for businesses.
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- With the Nam Viet Environmental Monitoring team, your company will receive professional service from experts in the monitoring field. At the same time, you will get the best cost incentives.
8. Workplace environment monitoring quotation
To help businesses perform workplace environment monitoring professionally and effectively, Nam Viet provides customers with a quality and reasonably priced quotation table for workplace environment monitoring services.
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