Tetrahydrofuran (C4H8O) is a common chemical in industry, but few people are fully aware of its negative impacts on workers’ health. This article will provide an overview of the health risks associated with exposure to Tetrahydrofuran in the workplace, helping readers better understand the necessary protective measures.
1. What is Tetrahydrofuran?
Tetrahydrofuran has the chemical formula C4H8O and is an organic compound belonging to the cyclic ether group. With a molecular structure consisting of four carbon atoms and one oxygen atom, Tetrahydrofuran has a ring-like shape, making it a very versatile solvent in chemical reactions. It exists as a colorless, volatile liquid with a mild odor.
Tetrahydrofuran is widely used in the chemical and plastics manufacturing industries. Due to its excellent solvency properties, Tetrahydrofuran is applied as a solvent in many production processes, including the manufacturing of various plastics, rubbers, and adhesives. Furthermore, this compound also plays a crucial role in organic synthesis, serving as a medium for many chemical reactions, especially in polymerization reactions.
Although Tetrahydrofuran has many useful applications, it also poses potential risks to human health, particularly for those working in environments where this chemical is used. A clear understanding of Tetrahydrofuran, from its properties to its applications, is crucial to ensure worker safety during its use.
| No. | Chemical Name in Vietnamese | Chemical Name in English | HS Code | CAS Number | Chemical Formula |
| 1. | Tetrahydrofuran | Tetrahydrofuran | 29321100 | 109-99-9 | C4H8O |
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2. Where does Tetrahydrofuran originate from in the production process?
This organic compound primarily originates from the production of other organic compounds, especially in the chemical industry. One of the most common methods for producing Tetrahydrofuran is through the hydrogenation of γ-butyrolactone, a compound derived from starch or other carbohydrate sources. This process typically occurs at high temperatures and pressures, using metal catalysts such as nickel or palladium.
Additionally, Tetrahydrofuran can also be produced by oxidizing compounds like butylene or butadiene. In this process, these substances are oxidized to form Tetrahydrofuran through a series of chemical reactions. This process usually takes place in large factories with modern equipment and strict quality control procedures.
Furthermore, Tetrahydrofuran can also be generated in other production processes such as the manufacturing of plastics, rubber, and other chemical products. In these processes, THF may be used as a solvent or an intermediate, leading to its release into the work environment.

3. Industries that use Tetrahydrofuran in production
This is a compound widely used in various industries due to its special chemical properties. One of the main fields using Tetrahydrofuran is plastics manufacturing. In the plastics production process, THF acts as a solvent that helps dissolve other compounds, thereby creating high-quality plastic products such as polyurethanes and polyvinyl chloride (PVC). The versatility of Tetrahydrofuran helps improve the mechanical properties of plastics, making the final product more durable and easier to use.
The rubber industry is also a significant field for the use of Tetrahydrofuran. In the production of synthetic rubber, THF is used to dissolve and mix different components, creating rubber with optimal properties for applications such as tires, construction materials, and other consumer products. The use of Tetrahydrofuran helps enhance the heat resistance and durability of rubber, thereby extending the product’s lifespan.
In addition, Tetrahydrofuran is also applied in the pharmaceutical and cosmetic industries. In the pharmaceutical sector, THF is used as a solvent in the extraction and purification of active ingredients, helping to increase the effectiveness of drugs. Meanwhile, in the cosmetics industry, Tetrahydrofuran plays an important role in creating products like skin creams, shampoos, and perfumes, thanks to its excellent ability to dissolve active ingredients.
Although Tetrahydrofuran brings many benefits to these industries, its use also comes with potential health risks. Therefore, workers need to be trained and equipped with adequate knowledge to ensure safety when working in an environment where Tetrahydrofuran is used.
4. How does Tetrahydrofuran affect workers?
Tetrahydrofuran can cause many negative impacts on the health of workers, especially with prolonged exposure or at high concentrations in the work environment. One of the first effects is on the respiratory system. When inhaling Tetrahydrofuran gas, workers may experience symptoms such as coughing, shortness of breath, and irritation of the respiratory mucous membranes. In some severe cases, this exposure can lead to lung problems, affecting the worker’s breathing ability.
Besides its impact on the respiratory system, Tetrahydrofuran can also cause skin problems. When in direct contact with the skin, THF can cause irritation, dermatitis, or itchy rashes. If not treated promptly, this condition can become serious and cause long-term health issues. In particular, individuals with sensitive skin or a history of allergies are at a higher risk of reacting to this chemical.
Furthermore, Tetrahydrofuran also has the potential to affect the central nervous system. Some studies have shown that exposure to THF can lead to symptoms such as dizziness, headaches, fatigue, and loss of concentration. In cases of long-term exposure, these symptoms can become more severe, affecting work performance and the quality of life of the worker.
Finally, Tetrahydrofuran can also cause more serious health problems, such as liver and kidney damage. People working in environments where this chemical is used need regular health monitoring to detect any abnormal symptoms early and take timely intervention measures. Therefore, raising awareness about the health impacts of Tetrahydrofuran on workers is extremely necessary, helping them to apply more effective preventive measures during their work.
5. Permissible safe concentration of Tetrahydrofuran for human exposure
The permissible safe concentration of Tetrahydrofuran for human exposure is a critical issue, as it helps protect the health of workers in industries that use this chemical. Health and occupational safety regulatory agencies, such as OSHA (U.S. Occupational Safety and Health Administration) and ACGIH (American Conference of Governmental Industrial Hygienists), have established permissible exposure limits to minimize the health risks posed by Tetrahydrofuran.
According to OSHA, the maximum permissible concentration of Tetrahydrofuran in the air is 200 ppm (parts per million) over an 8-hour work period. This means that during a normal workday, workers should not be exposed to THF concentrations exceeding this level to minimize the risk of developing chemical-related health problems. In addition, ACGIH also recommends a TLV-TWA (Threshold Limit Value-Time Weighted Average) of 50 ppm, emphasizing that lower concentration levels should be prioritized to ensure worker health and safety.
Furthermore, monitoring the concentration of Tetrahydrofuran in the work environment is extremely important. Companies should conduct periodic air tests to determine the actual THF concentration in the work area. If the concentration exceeds the permissible level, immediate mitigation measures must be taken, such as improving ventilation, using personal protective equipment, or even discontinuing the use of Tetrahydrofuran in production processes until the concentration is controlled.
Additionally, workers need to be trained on the risks associated with Tetrahydrofuran and how to recognize symptoms of exposure. Raising awareness and ensuring compliance with safety regulations are key factors in protecting the health of workers in environments where this chemical is used.

At a basic level, if working in an industrial environment, it is important to comply with safety standards and limit exposure to Tetrahydrofuran. Organizations like the Occupational Safety and Health Administration (OSHA) in the United States provide guidelines and safety principles to protect workers from the negative effects of chemical substances.
6. Measures to minimize the effects of Tetrahydrofuran on workers’ health
To minimize the health effects of Tetrahydrofuran on workers, a series of effective safety and prevention measures must be implemented. First, improving ventilation in work areas is extremely important. Factories and production facilities using Tetrahydrofuran should ensure they have adequate natural or mechanical ventilation systems to reduce the concentration of the chemical in the air, creating a safer working environment for employees.
In addition, the use of personal protective equipment is an indispensable part of protecting workers’ health. Employees working in environments with exposure to THF need to be equipped with respirators, gloves, protective clothing, and safety goggles. This equipment will help limit direct contact with the chemical, protecting the skin and respiratory tract of workers from the negative effects of Tetrahydrofuran.
Training and raising awareness for workers about the risks associated with Tetrahydrofuran also play a crucial role. Companies should organize regular training sessions to inform employees about exposure symptoms, how to recognize unsafe conditions, and response measures in case of an incident. Employees need to be equipped with knowledge on how to use and store chemicals correctly, thereby helping to minimize risks during the work process.
Furthermore, conducting regular health check-ups for workers is necessary. Through this, health problems can be detected early and treated promptly. Production facilities should also monitor and test the concentration of Tetrahydrofuran in the work environment to ensure it remains at a safe level.
Finally, establishing an incident response procedure for leaks or when THF concentrations exceed permissible levels is also a critical part of protecting workers’ health. By implementing these safety measures, companies not only protect the health of their employees but also enhance production efficiency and ensure a safe working environment.
Occupational safety training: Workers need to be trained and educated about the risks and safety measures when working with this type of chemical. This training should be provided periodically and regularly to ensure understanding and proper adherence to safety rules.
Periodically organize occupational environment monitoring in factories and enterprises, collecting and analyzing factors harmful to workers, thereby adjusting to reduce the level of hazard to prevent occupational diseases for them.
7. National Occupational Environment Monitoring Center
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