Tetrahydrothiophene (C4H8S) is a common chemical compound in many manufacturing plants, but few are aware of its potential impact on the health of workers. This article will help you better understand the risks of exposure to thiolane, as well as effective measures to protect your health.
1. What is Tetrahydrothiophene?
Tetrahydrothiophene, also known as thiolane, is an organic compound with the chemical formula C4H8S. It is a five-membered ring consisting of four carbon atoms and one sulfur atom, creating the characteristic structure of the thiophene group. Tetrahydrothiophene is volatile and has a distinctive odor, often used as an additive in the natural gas industry to enhance leak detection due to its strong, pungent smell.
The structural characteristics of C4H8S not only make it suitable for many industrial applications but also indicate its potential toxicity with frequent exposure. Because the sulfur atom in thiolane can form strong bonds with other substances, this compound easily interacts with the surrounding environment, affecting the air in the workspace. Therefore, when used in a production environment, Tetrahydrothiophene requires strict control measures to ensure worker safety.
| No. | Chemical Name in Vietnamese | Chemical Name in English | HS Code | CAS Number | Chemical Formula |
| 1. | Tetrahydro thiophen (thiolan) | Tetrahydrothiophene (thiolane) | 29349990 | 110-01-0 | C4H8S |
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2. Where does Tetrahydrothiophene originate from in the production process?
The organic compound Tetrahydrothiophene is commonly detected from the production and processing of natural gas and petrochemical products. In this industry, thiolane is added to natural gas as an odorant additive, helping to detect leaks more easily and provide timely warnings in case of an incident. This compound has a distinctive odor, so even a very small amount can be detected in the air, minimizing the risk of accidents for workers.
In addition, thiolane can be generated from the production of sulfur-containing compounds or chemical products containing sulfur. The synthesis of chemical substances or chemical reactions that create sulfur-containing compounds can also produce thiolane as a by-product. In the work environment

3. Industries that use Tetrahydrothiophene in production
This is a compound widely used in many industries, especially those related to the production and processing of natural gas, chemicals, and petroleum. In the natural gas industry, thiolane is added for the purpose of creating a distinctive odor, which helps to easily detect gas leaks – an important measure to protect the safety of workers and the surrounding environment. Natural gas production and distribution companies all use thiolane to ensure higher safety during transportation and management.
In addition, the chemical and petrochemical industries also use thiolane in the production process or as an additive for highly reactive chemical products. These industries require workers to have knowledge of chemical handling and safety procedures to minimize the risk of exposure to toxic substances. The plastics and rubber manufacturing industries also frequently use thiolane in their fabrication processes, as its chemical properties are suitable for certain synthesis processes and enhance product efficiency.
Finally, fields such as the production of solvents, lubricants, and some types of industrial paints may also use thiolane to improve product properties. However, due to the potential toxicity of thiolane, these industries must always place a high priority on protecting the health of workers, including providing protective equipment and building a safe work environment.
4. How does Tetrahydrothiophene affect workers?
Tetrahydrothiophene can have a negative impact on the health of workers when exposed for long periods or at high concentrations. Due to the chemical properties of this sulfur-containing compound, thiolane is aromatic and volatile, and when inhaled, it can irritate the respiratory system, leading to symptoms such as coughing, difficulty breathing, and nasal congestion. In particular, people working in enclosed, poorly ventilated environments are more likely to inhale thiolane, increasing the risk of respiratory effects.
In addition, thiolane can also cause skin and eye irritation upon direct contact. If workers do not use protective equipment such as gloves, safety glasses, or masks correctly, they may experience skin redness, itching, or even contact dermatitis with prolonged exposure to thiolane. These symptoms can be more severe for individuals with sensitive skin or a history of respiratory and skin diseases.
In the long run, continuous exposure to thiolane can cause more serious health problems, including muscle and liver damage. Studies have shown that long-term exposure to sulfur-containing compounds can impair respiratory function, cause chronic respiratory diseases, and affect liver function. In particular, when the concentration of thiolane in the environment exceeds the permissible level without proper control and protection measures, the risk to workers’ health is even higher.
5. Permissible safe concentration of Tetrahydrothiophene for human exposure
The safe concentration of Tetrahydrothiophene (thiolane) for human exposure is a crucial factor in protecting the health of workers. According to international standards, thiolane can affect health even at low concentrations if there are no proper protective measures. Therefore, occupational safety limits have been established to ensure that workers are not overexposed in the work environment.
The maximum permissible level (Threshold Limit Value – TLV) for Tetrahydrothiophene is generally limited to below 0.5 ppm (parts per million) in the air. This is the threshold at which workers can be continuously exposed during their work shifts without experiencing adverse health effects. However, if the concentration exceeds this level, the risk of harm to the respiratory system, skin, and eyes increases. Especially in enclosed environments or those lacking ventilation systems, thiolane can easily accumulate, increasing the risk for workers.
Factories and businesses that use thiolane must often develop air monitoring systems and regularly check the concentration of thiolane to ensure compliance with safety standards. In addition, workers are also encouraged to use personal protective equipment such as respirators, masks, and gloves when working in areas with high concentrations of thiolane. Furthermore, an effective ventilation system is an indispensable factor in reducing the concentration of thiolane in the air, helping to protect health and create a safe working environment.
Adhering to the safe concentration limits for Tetrahydrothiophene not only protects workers but also contributes to improving the quality of work and minimizing risks for the business.

On a basic level, if working in an industrial environment, it is important to adhere to safety standards and limit exposure to Tetrahydrothiophene (thiolane). Organizations like the Occupational Safety and Health Administration (OSHA) in the United States provide guidelines and safety principles to protect workers from the negative effects of chemical substances.
6. Measures to minimize the impact of Tetrahydrothiophene on workers’ health
To minimize the impact of Tetrahydrothiophene (thiolane) on the health of workers, applying safety protection measures is extremely important. First, companies need to build a safe working environment by conducting risk assessments at any time. This not only determines the concentration of thiolane in the air but also identifies the sources of this compound, thereby providing appropriate solutions.
One of the most effective measures is to improve the ventilation system in work areas where thiolane is used. Natural or mechanical ventilation systems help reduce the concentration of thiolane in the air, thereby minimizing the risk for workers. It is essential to install exhaust fans, ventilation, and open windows to allow fresh air to circulate.
In addition, providing personal protective equipment for workers is also very important. Workers should be supplied with respirators or protective masks capable of filtering volatile organic compounds, chemical-resistant gloves, and safety glasses when working in environments with high concentrations of thiolane. Training workers on how to properly use and maintain protective equipment also contributes to improving health protection effectiveness.
Companies should also implement regular health monitoring programs for workers. Regular health checks will help detect early symptoms related to thiolane exposure, allowing for timely intervention. In addition, emergency response measures should also be established, including first aid procedures in case of signs of poisoning or high exposure to thiolane.
Finally, raising awareness about occupational safety among the entire team is an indispensable factor. Training sessions on risk identification, prevention, and handling of incidents related to thiolane should be organized regularly so that all workers have sufficient knowledge and are proactive in protecting themselves and their colleagues. These solutions will help minimize the impact of Tetrahydrothiophene on the health of workers, creating a safer working environment.
Occupational safety training: Workers need to be trained and educated on the risks and safety measures when working with this type of chemical. This training should be provided periodically and regularly to ensure understanding and proper compliance with safety rules.
Periodically organize workplace environment monitoring in factories and enterprises, collect and analyze factors harmful to workers, and from there, adjust to reduce the level of harm to prevent occupational diseases for them.
7. National Workplace Environment Monitoring Center
The Workplace Environment Monitoring Center of Nam Viet is a professional unit specializing in the supervision and measurement of workplace environment quality across all provinces in Vietnam. With a team of experienced monitoring specialists, the center uses modern measuring equipment, ensuring accuracy and reliability.
REGISTER FOR WORKPLACE ENVIRONMENT MONITORING SERVICES
In addition to providing monitoring services, the center also supports clients in planning, handling, and tracking issues related to the workplace environment. With the motto “the customer is the center,” the center focuses on customer satisfaction, meeting all customer needs, and is committed to providing the best solutions for businesses.
With investment in techniques, technology, and human resources, Nam Viet’s monitoring center has become one of the reputable units in the field of workplace environment monitoring in Ho Chi Minh City with the following objectives:
- We always value our brand reputation and the quality of our products and services.
- We provide our customers with the best and most suitable solutions possible.
- With a team of experienced Masters and Engineers with a desire to protect the environment and benefit businesses.

- With the Nam Viet Environmental Monitoring team, your company will receive professional service from experts in the monitoring field. At the same time, you will get the best offers on costs.
8. Quotation for workplace environment monitoring
To help businesses carry out workplace environment monitoring professionally and effectively, Nam Viet offers our valued customers a price list for quality and reasonably priced workplace environment monitoring services.
- Our monitoring price list provides detailed information on the prices of the monitoring services we offer. This includes costs related to travel, measurement, analysis, and reporting of results. Customers can be completely assured of the accuracy and reliability of the monitoring result reports we provide.
- We are committed to always offering the most competitive and reasonable prices on the market, and we are also always ready to provide advice and answer any questions about our monitoring services quickly and professionally.
- With Nam Viet’s monitoring price list, customers can easily choose service packages that suit their needs. We are committed to bringing our customers the highest satisfaction with professional quality service.

