Acetyl chloride (CH3COCl) is a common chemical in many manufacturing plants, but few are aware that it can seriously affect the health of workers. This article will help you better understand the impact of acetyl chloride on health, from mild symptoms to serious medical conditions, along with the necessary preventive measures.
1. What is Acetyl chloride?
CH3COCl is a chemical compound belonging to the organic halogen group, specifically an acid halide. This colorless liquid has a pungent, characteristic odor and is highly volatile. Under normal conditions, acetyl chloride easily vaporizes and is soluble in organic solvents such as ethanol and benzene.
This compound is primarily produced through the reaction between acetic acid and thionyl chloride, creating acetyl chloride along with the by-products sulfur dioxide gas and hydrogen chloride. Due to its strong chemical properties, acetyl chloride is widely used in industry to synthesize many other organic compounds, such as esters and amides.
However, the use of acetyl chloride also poses many risks to human health.
| No. | Chemical Name in Vietnamese | Chemical Name in English | HS Code | CAS Number | Chemical Formula |
| 1. | Axetyl clorit | Acetyl chloride | 29159070 | 75-36-5 | CH3COCl |
See more: Chemical safety training service according to Decree 113/2017/ND-CP
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2. Where does Acetyl chloride originate from in the production process?
The source of acetyl chloride in the production process mainly comes from chemical processing and synthesis procedures. In many industrial plants, acetyl chloride is created through the reaction between acetic acid and thionyl chloride, a chemical widely used in manufacturing. This process typically takes place in specially designed reaction vessels to control temperature and pressure, in order to optimize the yield of acetyl chloride.
In addition to being produced directly, acetyl chloride can also be generated from other chemical reactions during the production of organic compounds, such as when it is used to convert other substances into esters or amides. In these cases, acetyl chloride is not only a product but also a reactant involved in many complex chemical reactions.
Furthermore, the use of acetyl chloride in the production process can also generate emissions or by-products that contain acetyl chloride.

3. Industries that use Acetyl chloride in production
Many industries use acetyl chloride as an important raw material in their production processes. In the chemical industry, acetyl chloride is often used to synthesize other organic compounds, such as esters and amides. These compounds are key ingredients in the production of medicines, plastics, detergents, and other chemical products.
The pharmaceutical industry is also a significant sector where acetyl chloride is used in the synthesis of various drugs. It plays a role in creating compounds with high biological activity, thereby helping to develop effective treatments for many diseases. In addition, acetyl chloride is also applied in the production of agricultural chemicals, such as pesticides and fertilizers, to improve crop yields.
Besides that, acetyl chloride is also used in the plastics industry to produce PVC and other polymer products. Thanks to its strong chemical properties, acetyl chloride contributes to improving the properties of plastic products, making them more durable and resistant.
Finally, the food industry also has some applications for acetyl chloride, mainly in the production of flavorings and food additives.
4. How does Acetyl chloride affect workers?
The impact of acetyl chloride on the health of workers is a serious issue that needs careful consideration. When exposed to this chemical, workers may experience various symptoms, ranging from mild reactions to more severe health problems. Acetyl chloride vapor can irritate the respiratory tract, leading to symptoms such as coughing, shortness of breath, and a sore throat. People working in environments with high concentrations of acetyl chloride are at a higher risk of developing bronchitis or chronic respiratory diseases.
In addition, acetyl chloride can also have negative effects on the skin and eyes. Upon direct contact, this liquid can cause burning, itching, and rashes on the skin. For the eyes, acetyl chloride can lead to severe irritation, including redness, tearing, and even corneal damage if not treated promptly. These symptoms are not only uncomfortable but can also affect work performance and the overall health of the worker.
In some severe cases, long-term exposure to acetyl chloride can lead to long-term health problems, including diseases of the liver, kidneys, and nervous system. Research shows that people who regularly work with acetyl chloride have a higher risk of developing chronic diseases due to the accumulation of toxins in the body.
5. Permissible safe concentration of Acetyl chloride for human exposure
Determining the permissible safe concentration of acetyl chloride for human exposure is very important to protect health and minimize risks for workers. According to the standards set by organizations such as OSHA (the U.S. Occupational Safety and Health Administration) and ACGIH (the American Conference of Governmental Industrial Hygienists), the maximum concentration of acetyl chloride in the workplace air is regulated at 1 part per million (ppm) over an 8-hour workday.
For work environments with specific characteristics, the maximum concentration may vary, but it must always be ensured that the exposure level does not exceed this limit to avoid adverse health effects. People working in factories that frequently use acetyl chloride need to undergo regular health monitoring to detect early signs of exposure to this chemical.
In addition, there must be effective control measures to maintain the concentration of acetyl chloride in the air at a safe level.

On a basic level, if working in an industrial environment, it is important to comply with safety standards and limit exposure to Acetyl chloride. Organizations like the Occupational Safety and Health Administration (OSHA) in the United States provide guidelines and safety principles to protect workers from the negative effects of chemical substances.
6. Measures to mitigate the effects of Acetyl chloride on workers’ health
To minimize the health effects of acetyl chloride on workers, safety and preventive measures are absolutely essential. First, establishing an effective ventilation system in the work area is indispensable. This system will help to circulate the air, removing acetyl chloride vapor and other toxic chemicals, thereby reducing the gas concentration in the air. In particular, ventilation equipment must be regularly inspected and maintained to ensure optimal performance.
Second, providing personal protective equipment (PPE) for workers is a crucial part of health protection. Workers should be supplied with protective masks with appropriate filters, chemical-resistant gloves, and safety goggles to protect their eyes and skin from direct contact with acetyl chloride. Training workers on how to use and maintain protective equipment should also be conducted regularly to raise self-protection awareness for each individual.
Third, companies should implement regular health monitoring programs for their employees. This includes monitoring for symptoms that may be related to acetyl chloride exposure, as well as periodically assessing general health indicators. If any abnormal signs are detected early, workers can receive support and timely treatment, helping to minimize long-term health impacts.
Finally, raising awareness and understanding of the dangers of acetyl chloride is also very important. Training sessions and workshops on chemical safety can help workers better understand the risks of working with acetyl chloride, as well as how to handle it safely in case of an incident. By building a safe work environment and providing adequate knowledge, businesses can protect the health of their employees and reduce the impact of acetyl chloride during production.
Occupational safety training: Workers need to be trained and educated on the risks and safety measures when working with this type of chemical. This training should be provided periodically and regularly to ensure understanding and proper adherence to safety rules.
Periodically organize work environment monitoring in factories and enterprises, collecting and analyzing factors harmful to workers, thereby adjusting to reduce the hazard level to prevent occupational diseases for them.
7. National Work Environment Monitoring Center
The Work Environment Monitoring Center of Nam Viet is a professional unit specializing in the supervision and measurement of work environment quality across all provinces in Vietnam. With a team of experienced monitoring specialists, the center uses modern measurement equipment, ensuring accuracy and reliability.
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In addition to providing monitoring services, the center also assists clients in planning, addressing, and tracking work environment issues. With the motto “the customer is the center,” the center is dedicated to customer satisfaction, meeting all of their needs, and committing to providing the best solutions for businesses.
With its investment in techniques, technology, and human resources, the Nam Viet monitoring center has become one of the most reputable units in the field of work environment monitoring in Ho Chi Minh City with the following objectives:
- We always value our brand reputation and the quality of our products and services.
- We provide our customers with the best and most suitable options possible.
- Along with a team of experienced and specialized Masters and Engineers, we aim to protect the environment and benefit businesses.

- By choosing the Nam Viet Environmental Monitoring team, your company will receive professional service from experts in the monitoring field. You will also receive the best cost incentives.
8. Quotation for Work Environment Monitoring
To help businesses conduct work environment monitoring professionally and effectively, Nam Viet offers our clients a quality and reasonably priced quotation table for work environment monitoring services.
- Our quotation table provides detailed information about the prices of the monitoring services we offer. This includes costs related to travel, measurement, analysis, and reporting of results. Clients can be completely assured of the accuracy and reliability of the monitoring result reports we provide.
- We are committed to always offering the most competitive and reasonable prices on the market, and we are also always ready to provide consultation and answer any questions about our monitoring services quickly and professionally.
- With Nam Viet’s quotation table, clients can easily choose the service packages that suit their needs. We are committed to providing our clients with the highest level of satisfaction through our professional quality service.

