Diethyl sulfate (C₄H₁₀O₄S) is a common chemical in many industries, but long-term exposure can cause serious health effects for workers. This article will analyze the dangerous impacts of diethyl sulfate and how to effectively prevent them to protect workers.
1. What is Diethyl sulfate?
The chemical formula C₄H₁₀O₄S represents an organic compound containing carbon, hydrogen, oxygen, and sulfur. It is an ester of sulfuric acid with ethyl groups, commonly used in many industries such as the production of pharmaceuticals, detergents, and in other chemical processes.
This substance is readily soluble in water and has a high reactivity with other substances, especially when in contact with strong acids or in high-temperature environments. Due to its chemical structure, diethyl sulfate can cause skin and eye irritation if not handled properly, and more severe effects with long-term exposure or at high concentrations.
With a molecular structure consisting of four carbon atoms, ten hydrogen atoms, four oxygen atoms, and one sulfur atom, this compound is characterized by its ability to easily participate in various chemical reactions, particularly in esterification and sulfonation reactions, making it an important substance in industrial production.
| No. | Chemical Name in Vietnamese | Chemical Name in English | HS Code | CAS Number | Chemical Formula |
| 1. | Dietyl sunfat | Diethyl sulfate | 29209090 | 64-67-5 | C₄H₁₀O₄S |
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2. What are the sources of Diethyl sulfate during production?
During the production process, this compound often arises from chemical reactions between compounds containing butyl groups and sulfuric acid. Specifically, when butanol (or substances with similar structures) reacts with sulfuric acid, an esterification reaction occurs, creating diethyl sulfate. This process takes place under high temperature and pressure conditions, increasing the likelihood of generating diethyl sulfate in an industrial environment.
Besides, diethyl sulfate can also be generated in some other production processes, such as the manufacturing of detergents, pharmaceuticals, or when organic compounds containing butyl groups participate in reactions with sulfuric acid in chemical environments. The presence of diethyl sulfate in the air, wastewater, or dust in industrial areas is a result of these processes, posing a potential risk to workers’ health if not controlled and handled properly.
In addition, in some cases, this compound can also arise during the use of products containing diethyl sulfate, when these products decompose or react with other substances in the industrial environment, creating harmful diethyl sulfate gas or vapor for those exposed.

3. Industries that use Diethyl sulfate in production
In industrial production, this compound is widely used in many different industries, mainly in fields that require special chemical reactions or the use of detergents and solvents. One of the prominent industries is pharmaceutical manufacturing, where diethyl sulfate is used in the synthesis of some types of drugs, especially in creating esters or compounds with special properties for the medical field.
The detergent manufacturing industry is also a significant area for the use of diethyl sulfate. This compound is often used to formulate powerful cleaning products that help remove tough stains or organic dirt. Due to its easy solubility and strong reactivity, diethyl sulfate becomes an important component in industrial and household detergent formulations.
In addition, the plastics and rubber industries also use diethyl sulfate in their production processes, particularly in chemical reactions to create additives that enhance the flexibility and durability of the products. This production process can create auxiliary compounds or chemicals with special features for high-end plastic products or technical applications.
In the chemical industry, diethyl sulfate plays an important role in esterification and sulfonation reactions, helping to create other organic compounds, thereby serving the production of other chemicals or chemical materials. Chemical manufacturing plants are places where this compound may arise during the processing of raw materials and final products.
4. How does Diethyl sulfate affect workers?
When in direct contact with diethyl sulfate, workers may experience skin and eye problems. Skin contact with this substance can cause irritation, redness, itching, or skin burns. The eyes can also be damaged, leading to conjunctivitis, eye pain, and in severe cases, may cause temporary or permanent blindness if not treated promptly.
Besides, when inhaling the vapor of diethyl sulfate in the work environment, workers may face respiratory problems. Symptoms such as coughing, shortness of breath, chest tightness, and pneumonia can appear with long-term exposure to gas or dust containing diethyl sulfate. Especially in enclosed work environments where the concentration of this compound can accumulate to high levels, the risk of respiratory diseases becomes more serious.
Prolonged exposure to diethyl sulfate can also cause chronic health problems. This compound can enter the body through the skin or respiratory tract and accumulate in internal organs. This can lead to long-term negative impacts, such as damage to the liver, kidneys, or nervous system. In cases of excessively high exposure concentration, the risk of poisoning or more serious health problems cannot be ruled out.
In addition, diethyl sulfate can also affect the reproductive system and cause physiological problems for workers if overexposed. Recent studies indicate that sulfur-containing compounds, when they enter the body, can cause hormonal disturbances and reduce fertility.
5. Permissible safe concentration of Diethyl sulfate for human exposure
To protect the health of workers, authorities and health organizations have regulated the safe concentration of this compound for human exposure. This concentration is usually determined based on studies of the health effects of long-term exposure and the accumulation of the compound in the body. In many countries, the maximum permissible concentration of diethyl sulfate in the workplace air typically ranges from 0.1 to 1 mg/m³, depending on factors such as the type of industry and the scale of production.
These standards are established to ensure that the level of exposure to diethyl sulfate does not cause immediate or long-term negative effects on workers. However, studies also show that even at low levels, if exposure is prolonged or repeated, this compound can still be harmful to health, especially to the respiratory system and skin.

On a basic level, when working in an industrial environment, it is important to adhere to safety standards and limit exposure to Diethyl sulfate. Organizations such as the Occupational Safety and Health Administration (OSHA) in the United States provide guidelines and safety principles to protect workers from the negative impacts of chemical substances.
6. Measures to mitigate the health effects of Diethyl sulfate on workers
To mitigate the effects of this compound on workers’ health, applying protective and preventive measures is very important in production processes. First of all, production facilities need to ensure good ventilation in work areas where diethyl sulfate is used. This helps to dilute the concentration of the compound in the air, minimizing the risk of inhaling vapor or dust containing diethyl sulfate, thereby limiting the impact on workers’ respiratory systems.
Besides, providing adequate personal protective equipment such as gloves, specialized masks, safety glasses, and protective clothing is a crucial measure. This equipment helps prevent direct contact of diethyl sulfate with the skin and eyes, protecting workers from irritation and burns caused by the chemical. In addition, when working with this compound, workers need to be fully trained on protective measures and procedures for handling incidents.
Another measure is the regular monitoring and testing of diethyl sulfate concentrations in the air, especially in production areas with high concentrations. Adhering to safety standards for maximum permissible concentrations helps to minimize negative impacts on workers’ health. Production facilities should conduct periodic inspections and implement timely corrective measures if concentrations exceed the permissible level.
Furthermore, procedures for handling spills or leaks of diethyl sulfate must be clearly established. Workers must be trained on how to use emergency handling equipment, such as fire extinguishers, spill cleanup systems, and neutralizing chemicals, to minimize damage and ensure worker safety in all situations.
Finally, improving working conditions, minimizing prolonged exposure, and organizing regular health programs for workers will help in the early detection of signs of diethyl sulfate’s impact on health, leading to timely and effective interventions.
Occupational safety training: Workers need to be trained and educated about the risks and safety measures when working with this type of chemical. This training should be provided periodically and regularly to ensure understanding and proper adherence to safety rules.
Periodically conduct occupational environmental monitoring in factories and enterprises, collecting and analyzing harmful factors for workers, thereby adjusting to reduce hazard levels to prevent occupational diseases for them.
7. Nationwide Occupational Environmental Monitoring Center
Nam Viet’s Occupational Environmental Monitoring Center is a professional unit for monitoring and measuring the quality of the working environment in all provinces across Vietnam. With a team of experienced monitoring specialists, the center uses modern measurement equipment, ensuring accuracy and reliability.
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In addition to providing monitoring services, the center also assists clients in planning, handling, and tracking issues related to the working environment. With the motto “the customer is the center,” the center focuses on customer satisfaction, meeting all customer needs, and is committed to providing the best solutions for businesses.
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8. Quotation for Occupational Environmental Monitoring
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