Epichlorohydrin (oxirane, (chloromethyl-) C3H5ClO) is an important chemical in the manufacturing industry, but it poses a serious health risk to workers. This article will help you better understand the health effects of Epichlorohydrin when working in an environment containing this chemical.
1. What is Epichlorohydrin (oxirane, (chloromethyl-)?
Epichlorohydrin (oxirane, (chloromethyl-), with the chemical formula C3H5ClO, is an organic compound with special chemical properties. It is used primarily in the chemical industry, especially in the production of epoxy resins, glycerin, and textile products. Epichlorohydrin’s molecular structure consists of three main elements: carbon (C), hydrogen (H), and chlorine (Cl), forming an oxirane ring (C3H5) with a chlorine group attached to the methyl group position.
This substance is volatile, colorless, and has a characteristic odor. Epichlorohydrin is produced mainly from propylene, a compound derived from petroleum, through a reaction with hypochlorite. Due to its properties, Epichlorohydrin readily reacts with other compounds to create many products with industrial applications.
In industry, Epichlorohydrin is a crucial raw material in the production of epoxy resin, a material widely used in construction, automotive, and electronics. It is also used to produce glycerin, a chemical with many applications in cosmetics, food, and pharmaceuticals. However, due to the toxicity of Epichlorohydrin, controlling and protecting the health of workers during production is very important.
| No. | Chemical Name in Vietnamese | Chemical Name in English | HS Code | CAS Number | Chemical Formula |
| 1. | Epiclohydrin | Epichlorohydrin (oxirane, (chloromethyl-) | 29103000 | 106-89-8 | C3H5ClO |
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2. Where does Epichlorohydrin (oxirane, (chloromethyl-) originate from in the production process?
During the production process, Epichlorohydrin mainly arises from the reaction between propylene and hypochlorite, a chlorine-containing compound. Propylene, a colorless liquid extracted from petroleum or natural gas, reacts with hypochlorite to create Epichlorohydrin through a series of chemical reactions. This reaction is usually carried out under controlled temperature and pressure conditions to ensure the highest efficiency in Epichlorohydrin production.
Besides that, some other methods can also be applied to produce Epichlorohydrin, including using glycerol or other compounds as input materials. However, the production process from propylene and hypochlorite remains the most common and effective method today. This process not only creates Epichlorohydrin but can also produce by-products, such as chlorides and toxic gases, if not handled correctly.

3. Industries that use Epichlorohydrin (oxirane, (chloromethyl-) in production
Epichlorohydrin is widely used in many different industries, mainly in the production of epoxy resins. Epoxy resin is a highly versatile material used in construction, automotive manufacturing, electronics, and even in the aerospace industry. It is a durable, heat-resistant, and chemical-resistant resin used as an adhesive, protective coating, and in the load-bearing parts of electronic devices.
Besides the plastics industry, Epichlorohydrin is also used in the production of glycerin, an important organic compound present in the pharmaceutical, cosmetic, and food industries. Glycerin is used as an ingredient in skin creams, ointments, beauty products, and some processed foods. In the textile industry, Epichlorohydrin is used to produce synthetic fibers, helping to create durable and waterproof materials.
In addition, Epichlorohydrin is also a raw material in the production of other chemicals such as detergents, industrial solvents, and additives in consumer products. The diversity in the application of Epichlorohydrin has made it an important compound in many different production fields.
4. How does Epichlorohydrin (oxirane, (chloromethyl-) affect workers?
During the production process, workers can be directly exposed to Epichlorohydrin through vapors, dust, or contact with products containing this compound. Long-term or high-concentration exposure to Epichlorohydrin can seriously affect workers’ health.
This compound can cause irritation to the skin, eyes, and respiratory tract. When inhaling Epichlorohydrin vapor, workers may experience symptoms such as coughing, difficulty breathing, chest tightness, and bronchitis. Prolonged exposure can lead to lung problems, affecting long-term respiratory capacity. In addition, skin contact can cause burns or severe irritation, especially when appropriate protection is not used.
Furthermore, Epichlorohydrin can also be toxic to the nervous system and affect liver and kidney function if workers are exposed for too long or in an environment with high concentrations. Some studies show that exposure to this compound can cause long-term effects, reducing the overall health of workers. In some severe cases, continuous exposure to Epichlorohydrin can increase the risk of cancer.
5. Permissible safe concentration of Epichlorohydrin (oxirane, (chloromethyl-) for human exposure
The permissible safe concentration of Epichlorohydrin for human exposure is regulated by health and occupational safety organizations such as OSHA (Occupational Safety and Health Administration) and ACGIH (American Conference of Governmental and Industrial Hygienists). According to these regulations, the maximum concentration of Epichlorohydrin in the air that a worker can be exposed to during an 8-hour workday (TWA – Time Weighted Average) is 0.5 ppm (parts per million).
These regulations are established to minimize the risk of health problems due to long-term exposure to this compound. Although there are safe limits, this concentration still requires strict protective measures, including the use of personal protective equipment such as respirators, gloves, protective clothing, and ensuring adequate ventilation in the work area. If the concentration of Epichlorohydrin exceeds the permissible limit, protective and control measures must be enhanced to protect workers’ health from harmful effects.
In addition, in some special cases, such as in environments with heavy work or long working hours, exposure to Epichlorohydrin should be reduced as much as possible, while strengthening air control measures and periodic health monitoring for workers.

At a basic level, if working in an industrial environment, it is important to adhere to safety standards and limit exposure to Epichlorohydrin. Organizations such as the Occupational Safety and Health Administration (OSHA) in the United States provide guidelines and safety principles to protect workers from the negative impacts of chemical substances.
6. Measures to minimize the effects of Epichlorohydrin (oxirane, (chloromethyl-) on workers’ health
To minimize the effects of Epichlorohydrin on workers’ health, protective measures must be strictly implemented in the work environment. One of the most important measures is to control the concentration of Epichlorohydrin in the air. Installing an effective ventilation system helps to reduce the accumulation of Epichlorohydrin vapor, ensuring that the air in the work area is always well-ventilated and meets safety standards.
Besides, the use of personal protective equipment (PPE) such as respirators, gloves, safety glasses, and protective clothing is essential to protect workers from direct contact with the chemical. In particular, respirators must be equipped with specialized filters capable of effectively filtering harmful substances from Epichlorohydrin.
Training and educating workers on safety measures when working with Epichlorohydrin is another important part. Workers need to be provided with full knowledge of the harmful effects of the chemical, how to use protective equipment, and emergency procedures in case of an incident. Production facilities need to organize regular training sessions and ensure that workers always have access to information about safety procedures.
Finally, periodic health monitoring of workers is an indispensable measure. Health checks help to detect early signs of occupational diseases or damage from long-term exposure to Epichlorohydrin, thereby allowing for timely intervention.
Occupational safety training: Workers need to be trained and educated about the risks and safety measures when working with this type of chemical. This training should be provided periodically and regularly to ensure understanding and proper adherence to safety rules.
Periodically organize workplace environment monitoring in factories and enterprises, collect and analyze factors harmful to workers, and then adjust to reduce the hazard level to prevent occupational diseases for them.
7. National Workplace Environment Monitoring Center
Nam Viet’s Workplace Environment Monitoring Center is a professional unit for monitoring and measuring the quality of the working environment across all provinces in Vietnam. With a team of experienced monitoring specialists, the center uses modern measuring equipment to ensure accuracy and reliability.
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8. Quotation for Workplace Environment Monitoring
To help businesses carry out workplace environment monitoring in a professional and effective manner, Nam Viet provides our customers with a quality and reasonably priced quotation for workplace environment monitoring services.
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