Hydroxyacetonitrile (glycolonitrile) is an industrial chemical used in many production processes. However, when workers are exposed to this substance, it can cause serious health effects. This article will analyze the health risks of working in an environment where hydroxyacetonitrile is used.
1. What is Hydroxyacetonitrile (glycolonitrile)?
Hydroxyacetonitrile (glycolonitrile), with the chemical formula C2H3NO, is an organic compound belonging to the nitrile group, known for its characteristic feature of having both a -CN (nitrile) group and an -OH (hydroxyl) group in its molecular structure. This substance is a colorless and volatile liquid. The chemical structure of hydroxyacetonitrile is a combination of a cyano group and a hydroxymethyl group, giving it strong reactive properties, and it is readily soluble in water and organic solvents.
Hydroxyacetonitrile is widely used in industries such as chemicals, pharmaceuticals, and the production of other organic compounds. It is an important raw material in the manufacturing of drugs, synthetic compounds, and auxiliary products. However, due to its nitrile group, this substance can have toxic effects, especially with long-term exposure to the human body or when safety procedures in production are not properly followed.
| No. | Chemical Name in Vietnamese | Chemical Name in English | HS Code | CAS Number | Chemical Formula |
| 1. | Hydroxy axetonitril | Hydroxyacetonitrile (glycolonitrile) | 29269000 | 107-16-4 | C2H3NO |
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2. Where does Hydroxyacetonitrile (glycolonitrile) originate from during the production process?
This substance is typically generated during the synthesis of organic compounds in the chemical industry. In production, it can be created through the reaction of cyanoacetic acid with oxidizing agents or by reacting with compounds containing a hydroxyl group. This synthesis process mainly occurs in factories producing chemical compounds such as pharmaceuticals, pesticides, or in the plastics industry. Additionally, hydroxyacetonitrile can also appear as a byproduct in the synthesis of other, more complex compounds.

3. Industries that use Hydroxyacetonitrile (glycolonitrile) in production
This substance is widely used in many industries, especially in the chemical and pharmaceutical sectors. In the chemical industry, it plays an important role in the synthesis of complex organic compounds, such as pesticides and compounds used in plastics manufacturing. It is also used in pharmaceutical synthesis processes to produce drugs for treating certain medical conditions.
Manufacturing industries involved in the creation of synthetic compounds or auxiliary products also use hydroxyacetonitrile in their processes. One of the specific applications of this substance is in the plastics industry, where it is used as an intermediate in the creation of polymers or composite materials. Chemical plants, pharmaceutical companies, and materials manufacturing facilities may all be exposed to hydroxyacetonitrile during their production processes.
4. How does Hydroxyacetonitrile (glycolonitrile) affect workers?
When workers are exposed to this substance in an industrial environment, it can have negative effects on their health. Inhaling the vapor of hydroxyacetonitrile can lead to respiratory irritation, causing coughing, shortness of breath, and other pulmonary symptoms. Additionally, this substance can be absorbed through the skin, causing irritation or allergic reactions in the contact areas, especially if the skin is broken or moist.
In cases of long-term exposure at high concentrations, hydroxyacetonitrile can cause more severe harm, affecting the nervous system and liver of workers. Symptoms can include headaches, dizziness, fatigue, and in severe cases, may cause permanent damage. This substance can also increase the risk of chronic diseases if not properly controlled and handled in the workplace.
5. Permissible safe concentration of Hydroxyacetonitrile (glycolonitrile) for human exposure
The permissible safe concentration for exposure to this substance is regulated by health and occupational safety agencies. Limits on vapor concentration in the air are often determined by standards such as the TLV (Threshold Limit Value) set by organizations like the ACGIH (American Conference of Governmental and Industrial Hygienists). In an industrial environment, this concentration is typically regulated at a very low level to minimize the risk of health effects on workers.
The permissible safe concentration of hydroxyacetonitrile in the air should not exceed 0.1 ppm (parts per million), depending on the specific regulations of each country and type of work.

On a basic level, if working in an industrial environment, it is important to comply with safety standards and limit exposure to Hydroxyacetonitrile. Organizations like the Occupational Safety and Health Administration (OSHA) in the United States provide guidelines and safety principles to protect workers from the negative effects of chemical substances.
6. Measures to minimize the health effects of Hydroxyacetonitrile (glycolonitrile) on workers
To minimize the health effects of this substance on workers, preventive measures must be strictly implemented during the production process. One of the most important measures is to use effective ventilation systems in high-risk areas. Ventilation helps to reduce the concentration of this substance in the air, preventing the inhalation of harmful vapors.
In addition, workers should be fully equipped with personal protective equipment such as masks, gloves, and safety glasses. This equipment helps to minimize direct contact with the toxic substance, protecting the skin and eyes from irritation. Organizing training for workers on the risks of working with hydroxyacetonitrile and how to use protective equipment is also very important. Regular health programs, including health check-ups and monitoring for risk signs, should also be implemented to detect any health problems caused by exposure to this substance early on.
Furthermore, work processes should be designed to minimize direct contact with this substance as much as possible. Workers should be instructed on how to handle and store the chemical safely, ensuring that containers or tools holding the substance do not leak or spill.
Occupational safety training: Workers need to be trained and educated about the risks and safety measures when working with this type of chemical. This training should be provided periodically and regularly to ensure understanding and proper compliance with safety rules.
Periodically organize occupational environment monitoring in factories and enterprises, collecting and analyzing factors harmful to workers, thereby adjusting to reduce hazard levels to prevent occupational diseases for them.
7. National Occupational Environment Monitoring Center
Nam Viet’s Occupational Environment Monitoring Center is a professional unit for monitoring and measuring the quality of the working environment across all provinces in Vietnam. With a team of experienced monitoring specialists, the center uses modern measuring equipment, ensuring accuracy and reliability.
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In addition to providing monitoring services, the center also supports clients in planning, handling, and tracking issues related to the occupational environment. With the motto “the customer is the center,” the center focuses on customer satisfaction, meeting all of the client’s needs, and committing to providing the best solutions for businesses.
With investment in techniques, technology, and human resources, Nam Viet’s monitoring center has become one of the reputable units in the field of occupational environment monitoring in Ho Chi Minh City with the following objectives:
- We always value our brand reputation and the quality of our products and services.
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- With a team of experienced Masters and Engineers with a desire to protect the environment and benefit businesses.

- With the Nam Viet Environmental Monitoring team, your company will receive professional service from experts in the monitoring field. At the same time, you will get the best cost incentives.
8. Quotation for occupational environment monitoring
To help businesses carry out occupational environment monitoring professionally and effectively, Nam Viet offers our valued customers a price list for occupational environment monitoring services that is high-quality and reasonably priced.
- Our price list provides detailed information about the prices of the monitoring services we offer. This includes costs related to travel, measurement, analysis, and reporting of results. Customers can be completely assured of the accuracy and reliability of the monitoring result reports we provide.
- We are committed to always offering the most competitive and reasonable prices on the market, and we are also always ready to provide consultation and answer any questions about our monitoring services quickly and professionally.
- With Nam Viet’s price list, customers can easily choose service packages that suit their needs. We are committed to bringing our customers the highest satisfaction with professional quality service.

