Toluene di-isocyanate (TDI) is a toxic chemical widely used in industrial production, but did you know it can seriously affect the health of workers? From respiratory irritation to the risk of occupational diseases, this article will help you understand the impact of TDI and how to protect yourself!
1. What is Toluene di-isocyanate?
Toluene di-isocyanate (TDI) is an organic compound belonging to the di-isocyanate group, with the chemical formula C9H6N2O2. In the TDI molecule, the structure consists of an aromatic toluene ring combined with two prominent isocyanate groups (-NCO), which gives this compound its strong reactivity. Thanks to its high reactivity, TDI is often used as a primary crosslinking agent in the production of polyurethane, helping to create products such as foam, rubber, and other elastic materials.
Besides its important role in the manufacturing industry, TDI is also highly valued for the adhesive efficiency and durability of the final product. However, due to the highly reactive and toxic nature of the -NCO groups, TDI must be handled and used under strictly controlled conditions. Safety management during the production and application of TDI is essential to protect the health of workers as well as the surrounding environment.
| No. | Chemical Name in Vietnamese | Chemical Name in English | HS Code | CAS Number | Chemical Formula |
| 1. | Toluen di-isoxyanat | Toluene di-isocyanate | 29291090 | 26471-62-5 | C9H6N2O2 |
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2. Where does Toluene di-isocyanate originate from in the production process?
Toluene di-isocyanate typically arises during the production of polyurethane, from the reaction between toluene and isocyanate gas. This process takes place in chemical plants, where raw materials like toluene and other chemicals are mixed and reacted under specific temperatures and pressures to form the final product. Throughout this process, TDI can be released as a gas or fine particles, especially during stages such as melting, stirring, or heating materials containing isocyanates. In addition to polyurethane production stages, TDI can also be generated in processes involving paints, adhesives, and coatings, where toluene di-isocyanate is used as a key component to improve the quality and durability of the product.

3. Industries that use Toluene di-isocyanate in production
In production, TDI is widely used in many different industries due to its strong reactivity and ability to form durable bonds. The polyurethane manufacturing industry is one of the largest users of TDI. Polyurethane is created through the reaction of TDI and polyols, and this product is then used to produce foam, rubber, elastic materials, as well as insulation, soundproofing, and tarpaulin products. These products are found in many industries, from automotive and construction to medical and consumer goods.
Besides the polyurethane industry, TDI is also used in the production of paints and coatings. In this field, TDI is involved in the formulation of paints and coatings that are heat-resistant, waterproof, and highly durable. These paint and coating products are widely used in construction, the automotive industry, and furniture production. TDI also plays an important role in the production of adhesives, especially in heat-resistant glues, adhesives for composite materials, and industrial adhesive products.
In addition, TDI is also used in the manufacturing of thermal insulation materials, including insulation panels for buildings, industrial equipment, and cold storage products. These insulation panels have good heat retention properties and high durability, thanks to the polyurethane structure created from the reaction between TDI and polyols. The packaging industry also uses TDI to produce protective materials, including foam products that protect goods during transportation.
Finally, TDI is also present in the field of manufacturing fire-resistant materials, where it is combined with additives to produce products with fire-retardant properties, enhancing safety for construction projects and vehicles.
4. How does Toluene di-isocyanate affect workers?
When exposed to TDI, workers can face many health risks due to the toxic and highly reactive nature of this compound. TDI can cause irritation to the respiratory tract, skin, and eyes, with symptoms such as coughing, difficulty breathing, itchy skin, red eyes, or swelling. Workers in environments with high TDI concentrations, such as in polyurethane or paint manufacturing plants, are at risk of developing chronic respiratory diseases, such as bronchitis or asthma, without appropriate protective measures.
In addition, inhaling TDI over a long period can lead to serious health problems, including lung damage, and even cardiovascular and nervous system issues. Workers with a history of respiratory diseases or allergies may experience more severe reactions when exposed to this compound. Due to the volatile nature of TDI, those working in areas without good ventilation systems or without using personal protective equipment are at risk of long-term exposure to the toxin.
TDI can also cause allergic reactions in some people, leading to symptoms such as itching, rashes, swelling, or difficulty breathing. Studies have shown that people who are regularly exposed to TDI can develop occupational asthma, especially in industries that produce elastic materials, foams, or adhesives. Patients with occupational asthma often face airway obstruction, shortness of breath, and a persistent cough, affecting their quality of life and ability to work.
In addition to immediate effects, long-term and uncontrolled exposure to TDI can increase the risk of developing cancer or other diseases related to the nervous system and liver.
5. Permissible safe concentration of Toluene di-isocyanate for human exposure
The permissible safe concentration of TDI for human exposure is regulated by international health and occupational safety agencies to protect the health of workers and the community. TDI is a toxic chemical, so determining a safe exposure level is very important. Organizations such as OSHA (U.S. Occupational Safety and Health Administration) and ACGIH (American Conference of Governmental Industrial Hygienists) have both set limits on the maximum concentration of TDI in the workplace air.
According to OSHA regulations, the TDI concentration must not exceed 0.02 ppm (parts per million) in the air over an 8-hour workday, with a maximum level not to exceed 0.2 ppm for 15 minutes. These figures are intended to minimize the risk of irritation or serious diseases caused by TDI, such as bronchitis or occupational asthma. These guidelines help control TDI concentrations in factories and manufacturing facilities, ensuring the safety of workers during their work.
In addition to the above limits, TDI must also be controlled in the work environment through measures such as effective ventilation and the use of personal protective equipment. These concentrations may vary depending on the regulations of each country or region, but the common goal is to minimize long-term and direct exposure to TDI, especially in environments with high TDI concentrations.

On a basic level, if working in an industrial environment, adhering to safety standards and limiting exposure to Toluene di-isocyanate is important. Organizations like the Occupational Safety and Health Administration (OSHA) in the United States provide guidelines and safety principles to protect workers from the negative impacts of chemical substances.
6. Measures to minimize the health effects of Toluene di-isocyanate on workers
To minimize the health effects of TDI on workers, protective measures must be strictly implemented in the work environment. One of the most important measures is controlling the concentration of TDI in the air. Factories and production facilities must maintain TDI levels in the air below the safety limits prescribed by health and occupational safety organizations. Installing effective ventilation and dust extraction systems can help reduce the dispersion of TDI into the work environment, thereby limiting workers’ exposure to the toxin.
In addition to controlling the work environment, the use of personal protective equipment is extremely important. Workers need to be equipped with gas masks, protective gloves, and protective clothing to prevent direct contact of TDI with the skin and respiratory tract. This protective equipment should be regularly inspected and maintained to ensure maximum protective effectiveness. Especially for those who work directly with TDI, the use of a fully enclosed protective suit is necessary to minimize exposure to the chemical.
Besides, training and raising awareness among workers about the risks and preventive measures when working with TDI is crucial. Workers need to be well-informed about the signs of TDI exposure and the procedures for handling incidents, such as immediately washing wounds or providing first aid for symptoms of poisoning. Organizing regular occupational safety training courses will help enhance awareness and skills for responding to dangerous situations.
Furthermore, regular health check-ups for workers are an important preventive measure. These health checks help to detect early signs of diseases caused by TDI, such as bronchitis, occupational asthma, or skin conditions. If a worker is found to be affected by TDI, timely treatment measures should be taken, and their job may need to be adjusted to reduce exposure to this chemical.
Finally, applying modern, environmentally friendly production technologies also helps to minimize the release of TDI during the production process. These technologies not only protect the health of workers but also contribute to protecting the surrounding environment.
Occupational safety training: Workers need to be trained and educated on the risks and safety measures when working with this type of chemical. This training should be provided periodically and regularly to ensure understanding and proper compliance with safety rules.
Periodically organize occupational environment monitoring in factories and enterprises, collect and analyze factors harmful to workers, thereby adjusting to reduce the level of hazard to prevent occupational diseases for them.
7. National Occupational Environment Monitoring Center
Nam Viet’s Occupational Environment Monitoring Center is a professional unit for monitoring and measuring the quality of the working environment across all provinces in Vietnam. With a team of experienced monitoring specialists, the center uses modern measuring equipment, ensuring accuracy and reliability.
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In addition to providing monitoring services, the center also assists clients in planning, handling, and tracking occupational environment issues. With the motto “the customer is the center,” the center focuses on customer satisfaction, meets all customer needs, and is committed to providing the best solutions for businesses.
With investment in technology, engineering, and human resources, Nam Viet’s monitoring center has become one of the reputable units in the field of occupational environment monitoring in Ho Chi Minh City with the following objectives:
- We always value our brand reputation and the quality of our products and services.
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- With a team of experienced Masters and Engineers with a desire to protect the environment and benefit businesses.

- With the Nam Viet Environmental Monitoring team, your company will receive professional service from experts in the monitoring field. You will also get the best cost incentives.
8. Quotation for Occupational Environment Monitoring
To help businesses carry out occupational environment monitoring professionally and effectively, Nam Viet offers our customers a quality and reasonably priced quotation table for occupational environment monitoring services.
- Our quotation table provides detailed information about the prices of the monitoring services we offer. This includes costs related to travel, measurement, analysis, and reporting of results. Customers can be completely assured of the accuracy and reliability of the monitoring result reports we provide.
- We are committed to always offering the most competitive and reasonable prices on the market, and we are also always ready to provide advice and answer any questions about our monitoring services quickly and professionally.
- With Nam Viet’s quotation table, customers can easily choose service packages that suit their needs. We are committed to bringing our customers the highest satisfaction with professional service quality.

