“
Diethyl Sulfate (C₄H₁₀O₄S) is a dangerous chemical, posing many risks to the health of workers in factories that use it. Long-term exposure can cause irritation, respiratory damage, and even cancer. So how can you protect your health? Let’s find out in this article!
1. What is Diethyl Sulfate?
Diethyl Sulfate, with the chemical formula (C₂H₅O)₂SO₂, is an ester of sulfuric acid in which two ethyl groups (C₂H₅) are bonded to the sulfur atom through oxygen atoms.
This compound exists as a colorless liquid with a characteristic odor and is known as a strong ethylating agent.
Diethyl Sulfate reacts strongly with water, producing ethanol and sulfuric acid. It also reacts with many organic compounds to add an ethyl group to their structure.
No. | Chemical Name in Vietnamese | Chemical Name in English | HS Code | CAS Number | Chemical Formula |
1. | Dietyl Sulfat | Diethyl Sulfate | 29209090 | 64-67-5 | C4H10O4S |
See more: chemical safety training service according to Decree 113/2017/NĐ-CP
REGISTER FOR CHEMICAL SAFETY TRAINING ACCORDING TO DECREE 113
2. Where does Diethyl Sulfate originate from in the production process?
In the production process, this compound is often created in industrial plants, especially during the processing of chemical products containing sulfur. It is mainly produced through the reaction between sulfuric acid and ethanol or other substances with an -OH group. When sulfuric acid reacts with ethanol, it creates Diethyl Sulfate along with water.
Furthermore, in the chemical industry, Diethyl Sulfate can also arise when using compounds containing ethyl groups to produce pharmaceuticals, dyes, or detergents. In these processes, Diethyl Sulfate is not the main product but may be generated as an additive or intermediate in chemical reactions.
Due to its reactive and toxic nature, Diethyl Sulfate is often present in production environments that use ethanol and sulfuric acid, creating a risk of accumulation in areas of direct contact or through emissions.
3. Industries that use Diethyl Sulfate in production
This compound is widely used in many industries, especially in the chemical and pharmaceutical manufacturing sectors. In the chemical industry, Diethyl Sulfate is an important ethylating agent, used to produce organic compounds with ethyl groups, such as in the manufacturing of dyes, surfactants, and other chemical compounds.
Additionally, in the pharmaceutical industry, Diethyl Sulfate serves as an intermediate in drug synthesis. It can be used to produce compounds with special properties needed for disease treatment. These products may include sedatives, antibiotics, and some types of cancer treatment drugs.
Besides that, this compound is also applied in the plastics, rubber, and detergent manufacturing industries. In some production processes, Diethyl Sulfate may be involved in creating products with anti-fouling properties or improving material durability. These industries require strict occupational safety measures to avoid the risks posed by the presence of Diethyl Sulfate.
4. How does Diethyl Sulfate affect workers?
When exposed to this compound, workers can experience many negative health effects. This compound can cause severe irritation to the skin and eyes, potentially leading to dermatitis, redness, itching, and severe damage upon direct contact. If the vapors of Diethyl Sulfate are inhaled, workers may experience symptoms such as coughing, difficulty breathing, chest pain, and even severe respiratory damage in cases of long-term exposure.
Prolonged exposure to this compound can also cause long-term health problems, such as liver and kidney damage, as Diethyl Sulfate can accumulate in the body after penetrating the skin or being inhaled. Additionally, studies have shown that Diethyl Sulfate can cause neurotoxicity, impairing central nervous system function, leading to dizziness, headaches, and prolonged fatigue symptoms.
In some cases, if workers are continuously and extensively exposed to Diethyl Sulfate, it can lead to a risk of developing cancer. Therefore, using occupational safety measures such as masks, gloves, and protective clothing is essential to minimize this risk.
5. Permissible safe concentration of Diethyl Sulfate for human exposure
Currently, specific information on safe exposure limits for Diethyl Sulfate has not been found in Vietnamese legal documents. Therefore, determining a safe exposure level for Diethyl Sulfate requires referencing international standards and best practices in the industry.
At a basic level, if working in an industrial environment, it is important to adhere to safety standards and limit exposure to Diethyl Sulfate. Organizations like the Occupational Safety and Health Administration (OSHA) in the United States provide guidelines and safety principles to protect workers from the negative effects of chemical substances.
6. Measures to mitigate the health effects of Diethyl Sulfate on workers
To minimize the impact of this compound on workers’ health, preventive measures must be implemented right from the production stage. Firstly, production facilities need to ensure good ventilation in work areas where Diethyl Sulfate is used, to minimize the accumulation of chemical vapors in the air. Installing exhaust ventilation systems or forced ventilation is necessary to remove toxic gases as soon as they are formed.
In addition, workers must be fully equipped with personal protective equipment, including chemical-resistant masks, gloves, safety goggles, and specialized protective clothing. This protective equipment plays a crucial role in preventing Diethyl Sulfate from coming into direct contact with the skin, eyes, and respiratory tract. Production facilities also need to organize regular occupational safety training for employees, helping them understand the risks and how to protect themselves when working with this chemical.
Furthermore, regular health monitoring for workers is indispensable. Periodic health check-ups will help detect the negative effects of long-term exposure to Diethyl Sulfate early, allowing for timely intervention. Work procedures need to be strictly controlled to minimize risks, such as limiting continuous working time with Diethyl Sulfate or establishing separate work areas for processes involving this chemical.
Occupational safety training: Workers need to be trained and educated on the risks and safety measures when working with this type of chemical. This training should be provided periodically and regularly to ensure understanding and proper compliance with safety rules.
Periodically organize workplace environment monitoring in factories and enterprises, collecting and analyzing factors harmful to workers, thereby adjusting to reduce hazard levels to prevent occupational diseases for them.
7. National Workplace Environment Monitoring Center
Nam Viet’s Workplace Environment Monitoring Center is a professional unit specializing in monitoring and measuring the quality of the working environment across all provinces in Vietnam. With a team of experienced monitoring specialists, the center uses modern measuring equipment, ensuring accuracy and reliability.
REGISTER FOR WORKPLACE ENVIRONMENT MONITORING SERVICE
In addition to providing monitoring services, the center also assists clients in planning, handling, and tracking workplace environment issues. With the motto “the customer is the center,” the center focuses on customer satisfaction, meeting all customer needs, and committing to providing the best solutions for businesses.
With investment in techniques, technology, and personnel, Nam Viet’s monitoring center has become one of the reputable units in the field of workplace environment monitoring in Ho Chi Minh City with the following objectives:
- We always value our brand reputation and the quality of our products and services.
- We provide our customers with the best and most suitable solutions possible.
- With a team of experienced Masters and Engineers with a desire to protect the environment and benefit businesses.

- With Nam Viet’s Environmental Monitoring team, your company will receive professional service from experts in the monitoring field. You will also get the best offers on costs.
8. Workplace Environment Monitoring Price Quotation
To help businesses carry out workplace environment monitoring professionally and effectively, Nam Viet offers our customers a price quotation for quality and reasonably priced workplace environment monitoring services.
- Our price quotation provides detailed information on the prices of the monitoring services we offer. This includes costs related to travel, measurement, analysis, and result reporting. Customers can be completely assured of the accuracy and reliability of the monitoring result reports we provide.
- We are committed to always offering the most competitive and reasonable prices on the market, and we are always ready to provide consultation and answer any questions about our monitoring services quickly and professionally.
- With Nam Viet’s price quotation, customers can easily choose service packages that suit their needs. We are committed to bringing our customers the highest satisfaction with our professional quality service.