3-Oxo-2-phenyl butane nitrile (C10H9ON) is a commonly used chemical in the manufacturing industry, but does it affect the health of workers? This article will explore the potential health impacts of this chemical when working in an environment where it is used.
1. What is 3-Oxo-2-phenyl butane nitrile?
3-Oxo-2-phenyl butane nitrile, with the chemical formula C10H9ON, is an organic compound belonging to the nitrile group. Its structure includes a phenyl group (C6H5) attached to a butane chain, which has a -C≡N (nitrile) group at the 2-position. The nitrile group (-C≡N) is characteristic of compounds that can participate in important chemical reactions in the chemical and pharmaceutical industries.
This compound has a molecular weight of approximately 159.185 g/mol and a boiling point of about 267.8°C. The chemical properties of 3-Oxo-2-phenyl butane nitrile allow it to be used in organic synthesis reactions, especially in creating other compounds for industrial production. However, exposure to this compound needs to be strictly controlled to ensure the safety of workers and the environment.
| No. | Chemical Name in Vietnamese | Chemical Name in English | HS Code | CAS Number | Chemical Formula |
| 1. | Alpha-phenyl acetoaceto nitril | 3-Oxo-2-phenyl butane nitrile | 29269000 | 4468-48-8 | C10H9ON |
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2. Where does 3-Oxo-2-phenyl butane nitrile originate from in the production process?
During the production process, this compound often arises from chemical processes related to the synthesis of organic compounds, particularly in the pharmaceutical and chemical industries. When producing compounds containing a nitrile group, such as acids, esters, or amides, a conversion reaction can occur that forms 3-Oxo-2-phenyl butane nitrile. These reactions often involve the combination of substances containing a phenyl group and other components like butane, along with the use of catalysts or specific temperature and pressure conditions.
This substance can also appear during synthesis from raw materials that initially contain a nitrile or carbonyl group, through chemical processing steps like oxidation or alkylation reactions. Additionally, in some industries that process and produce organic substances, this compound can be a byproduct in the synthesis of other compounds, especially when reaction conditions are incomplete or factors like temperature and reaction time are not tightly controlled.

3. Industries that use 3-Oxo-2-phenyl butane nitrile in production
The compound 3-Oxo-2-phenyl butane nitrile is used in many industries, especially in the chemical and pharmaceutical sectors. In the chemical industry, this compound is often used in the synthesis of other organic compounds, particularly those containing a nitrile group. It plays an important role in creating chemical products with high applicability, such as medicines, pharmaceuticals, or intermediate compounds in production processes.
Besides that, this compound is also used in the processing and manufacturing industry for raw materials that serve other industries. For example, in the plastics manufacturing industry, this compound may be used to synthesize polymers, or in the rubber and resin industry, it participates in chemical reactions to create additives. The use of 3-Oxo-2-phenyl butane nitrile in these fields often requires tightly controlled reaction conditions to ensure efficiency and safety during production.
4. How does 3-Oxo-2-phenyl butane nitrile affect workers?
When workers are exposed to this compound in a production environment, it can cause negative health effects if not properly controlled. Its main impacts on worker health are often related to the respiratory system and the skin. Inhaling the vapor of this substance can cause respiratory irritation, leading to symptoms such as coughing, difficulty breathing, or a burning sensation in the throat. In cases of prolonged exposure, workers may face more serious problems related to the lungs and respiratory system.
In addition, direct contact with 3-Oxo-2-phenyl butane nitrile can cause skin irritation, leading to redness, itching, or rashes. If not treated promptly, this condition can become more severe, leading to dermatitis or allergic reactions. This compound can also affect the eyes if workers do not use proper protection, causing eye irritation and a burning sensation.
Besides the direct effects on the body, long-term exposure to this compound can lead to more serious health problems, such as liver or kidney diseases, or may even increase the risk of cancer if occupational safety regulations are not fully followed in environments where this chemical is used.
5. Permissible safe concentration of 3-Oxo-2-phenyl butane nitrile for human exposure
Currently, there is no official and specific information about the permissible safe concentration for exposure to the compound 3-Oxo-2-phenyl butane nitrile in the workplace. However, chemical safety standards are typically regulated by authorities such as OSHA (Occupational Safety and Health Administration) in the US or ACGIH (American Conference of Governmental Industrial Hygienists). These regulations are usually based on scientific research and assessments to determine safe exposure limit thresholds for chemical substances.
To ensure safety, organizations and businesses need to monitor and control the concentration level of the chemical in the workplace air, especially in production areas where this chemical is used.

At a basic level, if working in an industrial environment, it is important to adhere to safety standards and limit exposure to Alpha-phenyl acetoaceto nitrile. Organizations such as the Occupational Safety and Health Administration (OSHA) in the United States provide guidelines and safety principles to protect workers from the negative impacts of chemical substances.
6. Measures to minimize the effects of 3-Oxo-2-phenyl butane nitrile on worker health
To minimize the health effects of this compound on workers, implementing safety measures is very important. First, it is necessary to establish an effective ventilation system in the work area to reduce the concentration of the chemical in the air. A ventilation system helps to dilute the chemical concentration, reduce accumulation, and prevent long-term exposure to high concentrations. Ensuring that work areas are well-ventilated and that air handling equipment such as exhaust fans and air filters are functioning correctly is essential.
Next, the use of personal protective equipment is necessary to protect workers from direct contact with the chemical. Specialized respirators, chemical-resistant gloves, and safety goggles help prevent the chemical from entering the body through the respiratory tract, skin, and eyes. In addition, waterproof protective clothing can also be used to protect the body from direct contact with the chemical.
Training and educating workers on safety measures when working with chemicals is very important. Workers need to be instructed on how to identify risks, use protective equipment correctly, and follow safety procedures. Regular training and drills help to raise awareness and improve the skills of workers in handling and responding to chemical-related emergencies.
In addition, implementing regular control and monitoring procedures also plays an important role in minimizing the effects of the chemical. Companies need to establish programs to check the chemical concentration in the air, maintain ventilation equipment, and treat exhaust gases. These measures help to ensure that the chemical concentration is always at a safe level and to promptly detect and resolve any issues that may arise.
Occupational safety training: Workers need to be trained and educated about the risks and safety measures when working with this type of chemical. This training should be provided periodically and regularly to ensure understanding and proper compliance with safety rules.
Periodically organize workplace environment monitoring in factories and enterprises, collect and analyze factors harmful to workers, and then adjust to reduce the hazard level to prevent occupational diseases for them.
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