In the growing context of the chemical industry, chemicals like trichloroacetic acid play an important role in many production processes. However, the improper use of trichloroacetic acid can significantly affect workers’ health. This article will discuss how trichloroacetic acid affects health, the potential risks, and the safety measures that need to be implemented to protect workers from the harmful effects of this substance.
1. What is Trichloroacetic acid?
Trichloroacetic acid (TCA) is a chemical compound with the molecular formula C₂HCl₃O₂. It is a type of chlorinated carboxylic acid and is one of the chlorinated forms of acetic acid. Trichloroacetic acid usually exists as a solution in water or as white crystalline particles.
TCA is commonly used in various applications, including as a corrosive agent for metals, a bleaching agent in the textile dyeing industry, and especially in the field of biochemistry to precipitate proteins in extraction and sample purification methods. However, due to its corrosive nature and potentially harmful effects on health, the use of trichloroacetic acid needs to be done carefully and correctly, especially in work environments.
| No. | Chemical Name in Vietnamese | Chemical Name in English | HS Code | CAS Number | Chemical Formula |
| 1. | Axit triclo axetic | Trichloroacetic acid | 29154000 | 76-03-9 | C2HO2Cl3 |
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2. Where does Trichloroacetic acid originate from in the production process?
Trichloroacetic acid (TCA) can be produced through various chemical methods, but one of the main methods is from acetic acid. Here is a common process:
- Chlorination: This process begins with acetic acid (CH₃COOH), a carboxylic acid. This acetic acid is then reacted with chlorine gas (Cl₂) under suitable temperature and pressure conditions. This reaction leads to the substitution of hydrogen atoms in the acetic acid molecule with chlorine, creating trichloroacetic acid.
- 2 CH₃COOH + Cl₂ → 2 CCl₃COOH + 2 HCl: Where CCl₃COOH is the formula for trichloroacetic acid and HCl is hydrochloric acid.
The final product is trichloroacetic acid (C₂HCl₃O₂), a clear liquid or white crystalline solid, depending on the temperature conditions and the amount of water present. Trichloroacetic acid can then be purified to achieve the desired purity for specific applications.

3. Industries that use Trichloroacetic acid in production
Trichloroacetic acid (TCA) is used in many different industries due to its special chemical properties. Here are some industries where TCA is commonly used in the production process:
- Biochemistry and Molecular Biology Industry: In the field of protein research and analysis, trichloroacetic acid is often used to precipitate proteins, helping to separate them from solutions.
- Textile Dyeing Industry: TCA can be used as a bleaching agent in the fabric treatment and dyeing process.
- Pharmaceutical Manufacturing Industry: In some cases, TCA may be used in the production and purification process of pharmaceutical compounds.
- Chemical Manufacturing Industry: TCA can be used as a corrosive agent for metals during the production of other chemicals.
- Paper Manufacturing Industry: In some cases, TCA may be used to control pH during the paper production process.
- Cosmetics Manufacturing Industry: TCA may be used in some skin care and beauty products.
4. How does Trichloroacetic acid affect workers?
Trichloroacetic acid (TCA) can affect the health of workers if safety measures are not followed when using or coming into contact with this substance. Here are some health problems that may occur:
- Irritation: TCA is a corrosive substance that can cause irritation to the skin, eyes, and respiratory tract. Direct contact with the skin can cause watering, redness, and pain.
- Watering and Eye Pain: If TCA comes into contact with the eyes, it can cause watering, pain, and severe irritation.
- Respiratory Tract Problems: Inhalation of TCA vapor can cause irritation to the respiratory tract and cause problems such as chest pain or difficulty breathing.
- Effects on the Digestive System: If TCA is swallowed, it can cause irritation to the digestive system, causing vomiting and abdominal pain.
- Systemic Effects: In some research cases, long-term exposure to TCA may cause adverse effects on the liver and kidneys.
To minimize the risk to workers, safety measures must be implemented, including the use of personal protective equipment such as goggles, gloves, and corrosion-resistant clothing. In addition, it is necessary to comply with the specific safety rules and usage instructions for each industry using TCA.
5. Permissible safe concentration of Trichloroacetic acid for human exposure
The safe concentration of trichloroacetic acid (TCA) for human exposure depends on the type of contact, duration of contact, and the specific context of the application. Safety regulations may vary by country and regulatory organization. Here is a reference for some commonly applied safety limits:
- Skin Contact: In industrial environments, the safe concentration of TCA on the skin is usually kept at a low level, often below 10% in solution. Direct application of high-concentration TCA on the skin can cause irritation and watering.
- Eye Contact: The safe concentration of TCA for eye contact is usually even lower, often below 5%. However, with all types of contact, the use of protective goggles is extremely important to protect the eyes from the effects of TCA.
- Inhalation: When exposed to TCA vapor, the safe concentration is usually kept at a low level, and the use of ventilation systems and respiratory protection is important.
At a basic level, if working in an industrial environment, it is important to comply with safety standards and limit exposure to Trichloroacetic acid. Organizations such as the Occupational Safety and Health Administration (OSHA) in the United States provide guidelines and safety principles to protect workers from the negative impacts of chemical substances.

6. Measures to minimize the effects of Trichloroacetic acid on workers’ health
To minimize the effects of trichloroacetic acid (TCA) on workers’ health, safety and preventive measures need to be applied. Here are some measures:
- Use Personal Protective Equipment (PPE):
- For skin contact: Use chemical-resistant gloves, corrosion-resistant clothing, and safety shoes.
- For eye contact: Wear protective goggles or a face shield to protect eyes from contact with TCA vapor or liquid.
- Ventilation System:
- Use an effective ventilation system to limit TCA vapor or particles in the air, reducing the risk of inhalation.
- Occupational safety training:
- Provide safety training for employees on how to use, store, and handle TCA correctly.
- Instructions on emergency measures and PPE use.
- Wastewater Control:
- Ensure that wastewater containing TCA is properly treated to prevent environmental pollution.
- Reduce Direct Contact:
- Use technologies and work processes that reduce direct contact with TCA, such as using automated systems.
- Risk Management:
- Implement risk management to identify and minimize risk areas that may arise during the use of TCA.
- Compliance with Safety Regulations:
- Comply with all safety regulations from regulatory agencies and public health related to the use of TCA.
Periodically organize working environment monitoring in factories and enterprises, collect and analyze factors harmful to workers, thereby adjusting to reduce hazard levels to prevent occupational diseases for them.
7. National center for monitoring the working environment
The center for monitoring the working environment of Nam Viet is a professional unit for monitoring and measuring the quality of the working environment across all provinces in Vietnam. With a team of experienced monitoring specialists, the center uses modern measuring equipment, ensuring accuracy and reliability.
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