Ethyl carbamate, also known as urethane, is a chemical compound used in various industries, including cosmetics, pharmaceuticals, and rubber manufacturing. However, ethyl carbamate is also known to be a human carcinogen. This article will discuss the impact of ethyl carbamate on the health of workers in manufacturing plants that use this chemical.
1. What is Ethyl carbamate?
Ethyl carbamate, also known as ethyl urethane, is an organic compound with the chemical formula C3H7O2N. It is an ester of carbamic acid and ethanol. Ethyl carbamate is typically found as a colorless solid or liquid with a mild, alcohol-like odor.
Structurally, ethyl carbamate has an ethyl group (C2H5-) bonded to a carbamate group (NHCOO-). The carbamate group consists of a carbonyl group (C=O) bonded to an amine group (NH2) via an ester group (O-).
| No. | Chemical Name in Vietnamese | Chemical Name in English | HS Code | CAS Number | Chemical Formula |
| 1. | Etyl cacbany | Ethyl carbamate | 29241900 | 51-79-6 | C3H7O2N |
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2. Where does Ethyl carbamate originate from in the production process?
Ethyl carbamate, or urethane, can be formed during various stages of the production of wine, beer, and other fermented products. Here are some of the main sources:
- Reaction between ethanol and urea: During fermentation, urea may be present from yeast nutrient sources such as nutrient solutions or from the decomposition of dead cells. Ethanol, the main product of fermentation, reacts with urea to form ethyl carbamate.
- Decomposition of amino acids: Some amino acids, like arginine, can naturally decompose during fermentation, creating nitrogen compounds that then react with ethanol to produce ethyl carbamate.
- Heat treatment processes: Heat treatment of alcoholic beverages, such as pasteurization, can promote the formation of ethyl carbamate. High temperatures accelerate the reaction between precursors and create more ethyl carbamate.
- Raw materials: Ethyl carbamate can also come from small amounts already present in raw materials such as grapes, sugarcane, or the grains used to produce alcoholic beverages.
Additionally, the choice of yeast strain and fermentation conditions can also influence the amount of ethyl carbamate formed. Therefore, strict control of these factors throughout the production process is necessary to minimize the formation of ethyl carbamate.

3. Industries that use Ethyl carbamate in production
In industry, Ethyl carbamate (EC) is widely used in the production process of certain specific products. One of the main industries that uses Ethyl carbamate is the alcohol and alcoholic beverage production industry. EC is a naturally occurring substance present in many types of alcohol, especially during fermentation and aging. However, controlling EC levels in alcohol is a major challenge, as it can be harmful to health if consumed at high levels.
Additionally, the food industry also uses Ethyl carbamate in production processes. EC can be naturally produced during the fermentation and aging of certain types of food as a byproduct. However, in some cases, controlling EC becomes important, especially for food products that are aged for a long time or mass-produced.
Furthermore, Ethyl carbamate is also used in the chemical industry, particularly in the production of organic compounds. EC can be used as an antioxidant, inhibitor, or coloring agent in some chemical processes. However, the use of EC in the chemical industry also raises issues related to safety and the environment, and strict regulations and standards must be adhered to.
4. How does Ethyl carbamate affect workers?
Ethyl carbamate, also known as urethane, is an organic compound that occurs naturally in many foods and beverages, including wine and beer. However, ethyl carbamate is also a toxic substance to humans if exposed to it at high levels. Workers in the food and beverage production industry may be exposed to ethyl carbamate through the production, processing, or packaging of products.
Some studies have shown that long-term exposure to ethyl carbamate can cause serious health problems for workers. Effects may include respiratory, skin, eye, and digestive system problems. In particular, ethyl carbamate is considered a carcinogen that can cause liver and bladder cancer in humans when exposed at high levels over a long period.
5. Permissible safe concentration of Ethyl carbamate for human exposure
Ethyl carbamate (EC), also known as urethane, is a chemical that can be found in some fermented foods and beverages, including wine, beer, spirits, and even some fruits and dairy products. Although EC is usually present at low levels, long-term exposure to higher concentrations can cause health problems.
International food safety regulatory bodies, such as the Codex Alimentarius Commission, have established maximum safe levels of EC allowed in food and beverages. This concentration is measured in milligrams per kilogram (mg/kg) and is called the Acceptable Daily Intake (ADI). The ADI level is set based on scientific studies on the toxicity of EC and is considered a safe level for people to consume daily throughout their lives without causing health harm.
In Vietnam, there are currently no specific regulations on safe concentrations of Ethyl carbamate in food. However, food producers often refer to the standards of Codex Alimentarius or other reputable organizations to ensure their products meet food safety requirements.

At a basic level, if working in an industrial environment, it is important to comply with safety standards and limit exposure to Ethyl carbamate. Organizations like the Occupational Safety and Health Administration (OSHA) in the United States provide safety guidelines and principles to protect workers from the negative impacts of chemical substances.
6. Measures to minimize the effects of Ethyl carbamate on workers’ health
Measures to minimize the effects of Ethyl carbamate on workers’ health are an essential part of the production and handling process for products containing this substance. To ensure worker safety, measures need to be applied from the raw material preparation stage to the production and storage processes.
One of the important measures is the use of advanced production methods and processing technologies. These technologies can minimize the formation and accumulation of Ethyl carbamate in the final product, reducing the risk of worker exposure to this substance.
In addition, establishing safe work procedures is also an indispensable part. Training employees on the risks and how to prevent exposure to Ethyl carbamate is necessary to enhance awareness and proactivity in protecting health.
The quality control system also plays an important role in minimizing the impact of Ethyl carbamate on workers. Regular inspection and risk assessment will help detect problems related to this substance early, thereby implementing timely corrective measures.
Furthermore, ensuring safe working conditions also plays an important role. Adjusting and periodically checking parameters such as temperature, pressure, and ventilation fans will help limit the dispersal of and exposure to Ethyl carbamate in the working environment.
Occupational safety training: Workers need to be trained and educated about the risks and safety measures when working with this type of chemical. This training should be provided periodically and regularly to ensure understanding and proper compliance with safety rules.
Periodically organize occupational environment monitoring in factories and enterprises, collect and analyze factors harmful to workers, thereby adjusting to reduce hazard levels to prevent occupational diseases for them.
7. National occupational environment monitoring center
Nam Viet’s occupational environment monitoring center is a professional unit specializing in monitoring and measuring the quality of the working environment across all provinces in Vietnam. With a team of experienced monitoring specialists, the center uses modern measuring equipment, ensuring accuracy and reliability.
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In addition to providing monitoring services, the center also supports clients in planning, handling, and tracking occupational environment issues. With the motto “the customer is the center”, the center focuses on customer satisfaction, meeting all customer needs, and committing to providing the best solutions for businesses.
With investment in techniques, technology, and human resources, Nam Viet’s monitoring center has become one of the reputable units in the field of occupational environment monitoring in Ho Chi Minh City with the following objectives:
- We always value our brand reputation and the quality of our products and services.
- We provide our customers with the best and most suitable solutions possible.
- With a team of experienced Masters and Engineers with expertise and a desire to protect the environment and benefit businesses.

- Coming to the Nam Viet Environmental Monitoring team, your company will receive professional service from experts in the monitoring field. At the same time, you will get the best cost incentives.
8. Quotation for occupational environment monitoring
To help businesses perform occupational environment monitoring professionally and effectively, Nam Viet provides customers with a quality and reasonably priced service quotation table for occupational environment monitoring.
- Our monitoring quotation table provides detailed information on the prices of the monitoring services we offer. This includes costs related to travel, measurement, analysis, and reporting of results. Customers can be completely assured of the accuracy and reliability of the monitoring result reports we provide.
- We commit to always offering the most competitive and reasonable prices on the market, and we are always ready to advise and answer any questions about monitoring services quickly and professionally.
- With Nam Viet’s quotation table, customers can easily choose service packages that suit their needs. We are committed to bringing customers the highest satisfaction with professional service quality.

