Hexamethyl phosphoro amide (C6H18N3OP) is an important industrial chemical, but long-term exposure to it can cause many adverse effects on workers’ health. This article will help you better understand the risks and protective measures when working with this chemical in a factory setting.
1. What is Hexamethyl phosphoro amide?
Hexamethyl phosphoro amide (C6H18N3OP) is an organophosphorus compound belonging to the phosphoramide group, with a molecular structure consisting of a phosphorus atom bonded to one amino group and three methyl groups. It is a colorless liquid, readily soluble in water and some organic solvents.
This chemical is commonly used in industry as a reagent in chemical synthesis processes, and is sometimes used in the production of agricultural products such as pesticides or plant protection chemicals. Due to its special chemical properties, hexamethyl phosphoro amide can interact with enzymes in the body, producing strong biological effects.
Its chemical structure allows this substance to be toxic if exposed to for long periods or not handled properly in an industrial environment.
| No. | Chemical Name in Vietnamese | Chemical Name in English | HS Code | CAS Number | Chemical Formula |
| 1. | Hexametyl photpho amit | Hexamethyl phosphoro amide | 29212900 | 680-31-9 | C6H18N3OP |
See more: Chemical safety training according to Decree 113/2017/NĐ-CP
REGISTER FOR CHEMICAL OCCUPATIONAL SAFETY TRAINING ACCORDING TO DECREE 113
2. Where does Hexamethyl phosphoro amide originate from in the production process?
During the production process, hexamethyl phosphoro amide can arise from various sources, mainly from chemical reactions between chemicals containing amino groups and phospho groups. It is a common compound in some industrial processes, especially in the chemical and agricultural industries.
When manufacturing plants use phosphorus compounds to produce pesticides or plant protection products, hexamethyl phosphoro amide can be formed as a byproduct of the synthesis process. In addition, this substance can also arise during the production of polymers or plastic materials, where phosphorus compounds are used as agents to improve the properties of the final product.
On the other hand, during the use and storage of chemicals, if safety and protection procedures are not strictly followed, hexamethyl phosphoro amide can be released into the environment. Processes such as leaks in storage warehouses, or uncontrolled decomposition in manufacturing plants, can all be sources of this chemical, creating a potential risk to workers’ health.

3. Industries that use Hexamethyl phosphoro amide in production
This substance is widely used in many different industries, especially in fields related to chemicals and agriculture. One of the main industries that uses this compound is the pesticide and plant protection product manufacturing industry. In pesticide synthesis processes, hexamethyl phosphoro amide plays an important role as an agent, helping to create products with high insecticidal efficacy and environmental stability.
In addition, this compound is also used in the plastics industry, especially in the production of polymers, synthetic resins, and plastic materials. Hexamethyl phosphoro amide has the ability to improve the properties of various types of plastics, making them more durable and resistant to harsh environmental factors.
The petrochemical and chemical processing industries also have a presence of hexamethyl phosphoro amide in their production processes. This substance participates in chemical reactions to produce other phosphorus compounds or is used as a catalyst in the synthesis of other products.
4. How does Hexamethyl phosphoro amide affect workers?
Exposure to this compound can cause many negative effects on workers’ health, especially with long-term exposure or without appropriate protective measures. Studies show that this substance can affect the nervous system, causing symptoms such as headaches, dizziness, fatigue, and difficulty concentrating. If in direct contact with the skin or inhaled, hexamethyl phosphoro amide can also cause irritation to the skin and respiratory mucous membranes, leading to dermatitis, coughing, shortness of breath, or lung problems.
In particular, when inhaling the smoke or vapor of this compound in the work environment, workers may experience more serious problems, including damage to internal organs such as the liver and kidneys. The long-term effects of hexamethyl phosphoro amide can also include a decline in physiological function, especially in the immune system and reproductive capacity.
In addition, continuous exposure to this chemical can cause long-term effects, such as metabolic disorders or digestive problems.
5. Permissible safe concentration of Hexamethyl phosphoro amide for human exposure
To protect the health of workers when working with this chemical, occupational safety and health regulatory agencies have determined permissible safe concentrations for exposure. However, this concentration may vary depending on factors such as the type of work, the level of exposure, and the duration of work in an environment where the compound is present.
According to regulations from organizations such as OSHA (Occupational Safety and Health Administration) and ACGIH (American Conference of Governmental Industrial Hygienists), the concentration of hexamethyl phosphoro amide in the air needs to be limited to avoid negative health effects. Usually, this permissible concentration is calculated in ppm (parts per million) or mg/m3. The limit values often vary, but in general, these concentrations must be lower than the level that can cause irritation or damage to the worker’s body.
If the concentration of hexamethyl phosphoro amide exceeds the permissible limit, the risk of developing occupational diseases increases significantly, especially for respiratory, neurological, and digestive problems.

At a basic level, when working in an industrial environment, it is important to comply with safety standards and limit exposure to Hexamethyl phosphoro amide. Organizations such as the Occupational Safety and Health Administration (OSHA) in the United States provide safety guidelines and principles to protect workers from the negative impacts of chemical substances.
6. Measures to minimize the effects of Hexamethyl phosphoro amide on workers’ health
To minimize the impact of this compound on workers’ health, implementing strict protective measures in the work environment is essential. First, companies need to ensure that all workers are fully equipped with personal protective equipment such as gloves, safety glasses, poison-resistant masks, and full-body protective suits, especially when working in an environment with the presence of this chemical. This equipment prevents direct contact with the skin and respiratory system, minimizing the risk of irritation or poisoning.
Besides that, improving ventilation in the work area is also an important measure. A good ventilation system helps to remove chemical vapors from the air, creating a fresh working environment and reducing the risk of inhaling toxic fumes. Air purifiers and exhaust systems should also be used to reduce the concentration of hexamethyl phosphoro amide in the air.
Another measure is to train and raise awareness for workers about the risks and prevention methods when working with this chemical. Workers need to clearly understand the potential effects of exposure to hexamethyl phosphoro amide and strictly adhere to occupational safety procedures. Managers need to conduct regular inspections and monitor the work environment to ensure that safety standards are maintained.
Finally, applying medical measures such as periodic health check-ups for workers to detect early symptoms that may be caused by exposure to this chemical is very important. The above measures not only help protect workers’ health but also contribute to improving production efficiency and minimizing risks in the work environment.
Occupational safety training: Workers need to be trained and educated about the risks and safety measures when working with this type of chemical. This training needs to be provided periodically and regularly to ensure understanding and proper compliance with safety rules.
Periodically organize workplace environment monitoring in factories and enterprises, collect and analyze factors harmful to workers, thereby adjusting to reduce the level of risk to prevent occupational diseases for them.
7. National Workplace Environment Monitoring Center
The Workplace Environment Monitoring Center of Nam Viet is a professional unit specializing in monitoring and measuring the quality of the working environment across all provinces in Vietnam. With a team of experienced monitoring specialists, the center uses modern measuring equipment, ensuring accuracy and reliability.
REGISTER FOR WORKPLACE ENVIRONMENT MONITORING SERVICE
In addition to providing monitoring services, the center also supports clients in planning, handling, and tracking workplace environment issues. With the motto “the customer is the center,” the center focuses on customer satisfaction, meeting all customer needs, and is committed to providing the best solutions for businesses.
With investment in technology, engineering, and human resources, Nam Viet’s monitoring center has become one of the reputable units in the field of workplace environment monitoring in Ho Chi Minh City with the following objectives:
- We always value our brand reputation and the quality of our products and services.
- We provide our customers with the best and most suitable options available.
- Together with a team of experienced Masters and Engineers with a desire to protect the environment and benefit businesses.

- With the Nam Viet Environmental Monitoring team, your company will receive professional service from experts in the monitoring field. At the same time, you will get the best deals on costs.
8. Quotation for Workplace Environment Monitoring
To help businesses carry out workplace environment monitoring professionally and effectively, Nam Viet offers our valued customers a price list for workplace environment monitoring services that is high-quality and reasonably priced.
- Our monitoring price list provides detailed information on the prices of the monitoring services we offer. This includes costs related to travel, measurement, analysis, and reporting of results. Customers can be completely assured of the accuracy and reliability of the monitoring result reports we provide.
- We are committed to always offering the most competitive and reasonable prices on the market, and we are also always ready to advise and answer any questions about monitoring services quickly and professionally.
- With Nam Viet’s monitoring price list, customers can easily choose service packages that suit their needs. We are committed to bringing our customers the highest satisfaction with professional quality service.

