Methyl chloroformate (Carbonochloridic acid, methylester) is a toxic chemical, often used in manufacturing industries. This article will help you understand the impact of Methyl chloroformate on the health of workers in a factory environment and propose effective protective measures.
1. What is Methyl chloroformate (Carbonochloridic acid, methylester)?
Methyl chloroformate (Carbonochloridic acid, methylester) is a chemical compound with the molecular formula C2H3ClO2. It is an ester of carbonic acid, formed by the reaction between methanol and methyl chloroformate. Methyl chloroformate is a transparent, volatile liquid with a characteristic odor, commonly used in the production of pharmaceuticals, plastics, and other industrial chemicals.
Methyl chloroformate belongs to the group of halogenated organic compounds, with a chlorine (Cl) atom in its molecular structure. This makes it highly reactive and allows it to easily participate in chemical reactions, especially methylation reactions. In an industrial setting, Methyl chloroformate is primarily used in chemical synthesis processes, where it acts as a methylating agent, meaning it helps to add a methyl group (-CH3) to other molecules.
Despite its widespread use in industrial production, Methyl chloroformate is a toxic compound. Therefore, when working with this chemical, strict protective measures must be followed to ensure the safety of workers and the surrounding environment.
| No. | Chemical Name in Vietnamese | Chemical Name in English | HS Code | CAS Number | Chemical Formula |
| 1. | Metyl cloformat | Methyl chloroformate (Carbonochloridic acid, methylester) | 29159090 | 79-22-1 | C2H3ClO2 |
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2. Where does Methyl chloroformate (Carbonochloridic acid, methylester) originate from during the production process?
During the production process, this compound primarily arises from the chemical reaction between methanol and phosgene. Phosgene is a toxic gas used in many chemical industries. When phosgene reacts with methanol, it produces Methyl chloroformate, along with a certain amount of CO2 gas. This is a compound that needs to be prepared and used carefully in chemical plants because it is volatile and can be released into the environment if not tightly controlled.
In addition, in some other production processes, this compound can also be formed with the involvement of other chemicals such as hydrochloric acid or chlorinated compounds. In industrial plants, Methyl chloroformate is also produced through chemical synthesis processes, using methanol and phosgene as raw materials under specific temperature and pressure conditions.

3. Industries that use Methyl chloroformate (Carbonochloridic acid, methylester) in production
This compound is widely used in the chemical industries, especially in the production of pharmaceuticals, plastics, and other specialty chemicals. In the pharmaceutical industry, it plays a crucial role in the synthesis of drugs, particularly active compounds with anti-cancer, anti-inflammatory, or other therapeutic properties. The applications of Methyl chloroformate help improve the efficiency of drug synthesis and production, thanks to its ability to add a methyl group (-CH3) to organic molecules.
The plastics industry also uses this compound to produce various polymers, epoxy resins, and other synthetic materials. Methyl chloroformate helps improve the mechanical properties and durability of plastics, thereby creating high-quality products for various purposes, from construction to electronics. Additionally, in the chemical industry, Methyl chloroformate is used to produce other chemical compounds, such as intermediates for chemical synthesis.
This compound also appears in the production processes of specialty chemicals, such as foaming agents, catalysts, or auxiliary products in the rubber and insulating materials industries. Thanks to its characteristic chemical properties, Methyl chloroformate has become an indispensable raw material in many different manufacturing fields.
4. How does Methyl chloroformate (Carbonochloridic acid, methylester) affect workers?
This chemical can have serious health effects on workers upon direct contact or inhalation of its vapors in the work environment. When inhaled, it can cause respiratory irritation, leading to symptoms such as coughing, shortness of breath, sore throat, and even pneumonia. Those with long-term exposure to this compound may experience more severe health problems, such as chronic lung damage or impaired respiratory function.
Furthermore, contact with the skin or eyes can also cause severe irritation, leading to red, itchy, or rash-prone skin. If it comes into contact with the eyes, this compound can cause serious damage, leading to conjunctivitis or corneal ulcers. In cases of severe contact, workers may suffer from chemical burns or deep ulcerations.
This chemical also has the potential to affect the nervous system, especially when workers are exposed to a large amount or for a long period. Symptoms may include dizziness, nausea, headaches, and fatigue. Neurological problems can be long-lasting, affecting the ability to work and the quality of life of the worker.
5. Permissible safe concentration of Methyl chloroformate (Carbonochloridic acid, methylester) for human exposure
The permissible safe concentration for exposure to this chemical is regulated by international health and occupational safety organizations, such as OSHA (U.S. Occupational Safety and Health Administration) and ACGIH (American Conference of Governmental Industrial Hygienists). According to these guidelines, the maximum permissible concentration in the workplace air is 0.2 ppm (parts per million). This is the accepted safe level for workers to be able to work without facing serious short-term health risks.
However, this safe exposure level may vary depending on national regulations, type of work, and duration of exposure. These organizations also provide standards for short-term exposure limits (STEL) and 8-hour time-weighted average (TWA) exposure limits, to protect workers from long-term effects.

On a basic level, if working in an industrial environment, it is important to comply with safety standards and limit exposure to Methyl chloroformate. Organizations like the Occupational Safety and Health Administration (OSHA) in the United States provide guidelines and safety principles to protect workers from the negative effects of chemical substances.
6. Measures to minimize the health effects of Methyl chloroformate (Carbonochloridic acid, methylester) on workers
To minimize the health effects of this chemical on workers, implementing personal protective measures and improving the work environment are very important. First and foremost, workers must use adequate personal protective equipment such as gas masks, safety goggles, gloves, and specialized protective clothing. Masks and respirators with appropriate filters will help prevent the inhalation of toxic vapors in the air.
In addition, improving ventilation in the work area plays a crucial role in reducing the concentration of Methyl chloroformate in the air. It is necessary to ensure that production areas have a powerful ventilation system that can extract toxic gases and supply clean replacement air. Installing exhaust fans, blowers, and cooling systems will help reduce the accumulation of this chemical in the work environment.
Besides personal protective measures and improved ventilation, training and raising awareness for workers about the risks and preventive measures when working with this chemical is also extremely important. Workers need to clearly understand safety procedures, know how to use personal protective equipment, and recognize the early symptoms of poisoning for timely response.
Finally, businesses need to conduct regular monitoring of the work environment and check the concentration of Methyl chloroformate in the air. Ensuring that regulations on safe concentrations are followed will help protect the long-term health of workers.
Occupational safety training: Workers need to be trained and educated about the risks and safety measures when working with this type of chemical. This training should be provided periodically and regularly to ensure understanding and proper compliance with safety rules.
Periodically organize occupational environment monitoring in factories and enterprises, collecting and analyzing factors harmful to workers, thereby adjusting to reduce hazard levels to prevent occupational diseases for them.
7. National Occupational Environment Monitoring Center
Nam Viet’s Occupational Environment Monitoring Center is a professional unit for monitoring and measuring the quality of the working environment across all provinces in Vietnam. With a team of experienced monitoring specialists, the center uses modern measuring equipment, ensuring accuracy and reliability.
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In addition to providing monitoring services, the center also supports clients in planning, handling, and tracking issues related to the occupational environment. With the motto “the customer is the center,” the center focuses on customer satisfaction, meeting all of the client’s needs, and committing to providing the best solutions for businesses.
With investment in techniques, technology, and human resources, Nam Viet’s monitoring center has become one of the reputable units in the field of occupational environment monitoring in Ho Chi Minh City with the following objectives:
- We always value our brand reputation and the quality of our products and services.
- We provide our customers with the best and most suitable solutions possible.
- With a team of experienced Masters and Engineers with a desire to protect the environment and benefit businesses.

- With the Nam Viet Environmental Monitoring team, your company will receive professional service from experts in the monitoring field. At the same time, you will get the best cost incentives.
8. Quotation for occupational environment monitoring
To help businesses carry out occupational environment monitoring professionally and effectively, Nam Viet offers our valued customers a price list for occupational environment monitoring services that is high-quality and reasonably priced.
- Our price list provides detailed information about the prices of the monitoring services we offer. This includes costs related to travel, measurement, analysis, and reporting of results. Customers can be completely assured of the accuracy and reliability of the monitoring result reports we provide.
- We are committed to always offering the most competitive and reasonable prices on the market, and we are also always ready to provide consultation and answer any questions about our monitoring services quickly and professionally.
- With Nam Viet’s price list, customers can easily choose service packages that suit their needs. We are committed to bringing our customers the highest satisfaction with professional quality service.

