Methyl formate (C2H4O2) is a chemical that frequently appears in manufacturing plants, but few people are fully aware of its impact on the health of workers. This article will explore the potential risks and ways to protect health in a work environment where methyl formate is used.
1. What is Methyl formate?
Methyl formate, with the chemical formula C2H4O2, is an organic compound belonging to the ester group of formic acid. It is a colorless liquid with a pleasant smell similar to that of green apples. Methyl formate is primarily produced through the reaction between methanol and formic acid. In the molecular structure of methyl formate, the ester functional group (-COO-) connects a methyl group (-CH3) and formic acid (HCOOH). It is a volatile compound, soluble in water, ethanol, and other organic solvents.
Methyl formate is widely used in various industries, especially in the production of paints, pesticides, antifreeze, and in the food processing industry as a flavoring agent. However, despite its many industrial applications, methyl formate can also be hazardous if not used and handled properly, as it can cause irritation to those exposed to it for a long period.
| No. | Chemical Name in Vietnamese | Chemical Name in English | HS Code | CAS Number | Chemical Formula |
| 1. | Metyl format | Methyl formate | 29151300 | 107-31-3 | C2H4O2 |
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2. Where does Methyl formate originate from during the production process?
During the production process, this compound is usually generated from the chemical reaction between methanol and formic acid. This is an esterification reaction, where methanol, a simple alcohol, reacts with formic acid to produce methyl formate and water. This reaction can be carried out at high temperatures and pressures to accelerate the reaction rate and optimize the yield of methyl formate.
Additionally, methyl formate can also be formed in some other production processes, such as when chemicals containing methyl and formic acid groups are combined under special chemical conditions. This process often occurs in chemical plants, paint and pesticide manufacturing facilities, and in food-related industries where methyl formate is used as a solvent or flavoring agent.

3. Industries that use Methyl formate in production
Methyl formate is used in many different industries due to its special properties. In the paint industry, methyl formate is often used as a solvent in paints, varnishes, and other surface coating products, helping to dissolve other components and improve the durability of the coating. In addition, this compound is also an important substance in pesticide production, where it is used as a solvent for the active chemical ingredients needed in the crop protection process.
In the food industry, methyl formate is used as a flavoring agent, especially in the production of products with a light, pleasant aroma such as soft drinks, candies, and various processed foods. This compound is also used in applications within the pharmaceutical industry, where it serves as a solvent in chemical synthesis processes. Besides that, methyl formate is also used in the plastics, detergents, and antifreeze manufacturing industries, thanks to its solubility and stability under various temperature and pressure conditions.
4. How does Methyl formate affect workers?
When workers are exposed to methyl formate in the workplace, they may experience several negative health effects. This compound is highly volatile, so when methyl formate vapor is inhaled, workers may experience respiratory irritation symptoms such as coughing, shortness of breath, and rhinitis. Headaches and dizziness are also common with long-term exposure to this compound, as methyl formate can affect the nervous system.
Furthermore, if methyl formate comes into direct contact with the skin or eyes, it can cause skin irritation, redness, and dermatitis. The eyes are also susceptible to damage, with symptoms such as tearing, stinging, and redness. Prolonged exposure to high concentrations of methyl formate can lead to more serious problems, such as poisoning or permanent damage to the respiratory organs, skin, and eyes.
Especially in poorly ventilated or unsafe working conditions, workers may face the risk of acute poisoning, leading to severe symptoms such as nausea, vomiting, rapid breathing, and even fainting. This can cause long-term harm if protective measures and exposure risk controls are not in place.
5. Permissible safe concentration of Methyl formate for human exposure
The permissible safe concentration of methyl formate for human exposure is regulated by health and occupational safety organizations to protect workers’ health. These limits are usually measured by the maximum concentration that a worker can be exposed to in the air without experiencing dangerous side effects. In many countries, this limit is determined based on research on the health effects of methyl formate on humans.
The OSHA (Occupational Safety and Health Administration) in the United States sets the maximum concentration of methyl formate in the air at 25 ppm (parts per million) for an 8-hour workday. Similarly, the ACGIH (American Conference of Governmental Industrial Hygienists) also provides a similar limit for the concentration of methyl formate in the work environment. This is a safe level to protect workers from short-term effects such as irritation of the respiratory tract, skin, and eyes. However, if the concentration exceeds this level, workers may experience uncomfortable and dangerous symptoms, and appropriate protective measures such as ventilation or personal protective equipment are required.

On a basic level, if working in an industrial environment, it is important to comply with safety standards and limit exposure to Methyl formate. Organizations like the Occupational Safety and Health Administration (OSHA) in the United States provide guidelines and safety principles to protect workers from the negative effects of chemical substances.
6. Measures to minimize the health effects of Methyl formate on workers
To minimize the health effects of methyl formate on workers, protective measures and control of the work environment are extremely important. One of the most effective measures is to ensure adequate ventilation in production areas where methyl formate is used. Improving the ventilation system helps to reduce the concentration of methyl formate in the air, thereby limiting the risk of long-term exposure to this compound.
In addition, personal protective equipment such as respirators, gloves, and safety goggles are necessary to protect workers from direct contact with methyl formate. This equipment helps prevent the chemical from coming into contact with the skin and eyes, while also minimizing the chance of inhaling methyl formate vapor during work.
It is also important to focus on training and raising awareness among workers about the potential risks of working with methyl formate. This helps them understand how to use protective equipment, as well as how to recognize and promptly handle hazardous situations.
Finally, regularly monitoring and testing the concentration of methyl formate in the workplace air is a crucial measure to ensure that exposure levels do not exceed safe limits. If necessary, corrective measures such as reducing the amount of methyl formate used or replacing it with a safer chemical can be applied to protect workers’ health.
Occupational safety training: Workers need to be trained and educated about the risks and safety measures when working with this type of chemical. This training should be provided periodically and regularly to ensure understanding and proper compliance with safety rules.
Periodically organize occupational environment monitoring in factories and enterprises, collecting and analyzing factors harmful to workers, thereby adjusting to reduce hazard levels to prevent occupational diseases for them.
7. National Occupational Environment Monitoring Center
Nam Viet’s Occupational Environment Monitoring Center is a professional unit for monitoring and measuring the quality of the working environment across all provinces in Vietnam. With a team of experienced monitoring specialists, the center uses modern measuring equipment, ensuring accuracy and reliability.
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In addition to providing monitoring services, the center also supports clients in planning, handling, and tracking issues related to the occupational environment. With the motto “the customer is the center,” the center focuses on customer satisfaction, meeting all of the client’s needs, and committing to providing the best solutions for businesses.
With investment in techniques, technology, and human resources, Nam Viet’s monitoring center has become one of the reputable units in the field of occupational environment monitoring in Ho Chi Minh City with the following objectives:
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- With a team of experienced Masters and Engineers with a desire to protect the environment and benefit businesses.

- With the Nam Viet Environmental Monitoring team, your company will receive professional service from experts in the monitoring field. At the same time, you will get the best cost incentives.
8. Quotation for occupational environment monitoring
To help businesses carry out occupational environment monitoring professionally and effectively, Nam Viet offers our valued customers a price list for occupational environment monitoring services that is high-quality and reasonably priced.
- Our price list provides detailed information about the prices of the monitoring services we offer. This includes costs related to travel, measurement, analysis, and reporting of results. Customers can be completely assured of the accuracy and reliability of the monitoring result reports we provide.
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