N-Butyl formate (C5H10O2) is a common chemical in manufacturing plants, but few people know about its potential impact on worker health. This article will explore in detail the risks of exposure to N-Butyl formate, as well as protective measures to ensure occupational safety.
1. What is N-Butyl formate?
N-Butyl formate has the chemical formula C5H10O2, belongs to the ester group, and is an organic compound created from the combination of formic acid and butanol. It exists as a colorless liquid, has a light fruity odor, and is used in many industrial fields. In particular, N-Butyl formate is often used as a solvent in the production of paints, printing inks, and synthetic plastic products.
In addition, N-Butyl formate also plays an important role in the preparation of other chemical compounds and participates in the production of flavorings. Thanks to its rapid evaporation and stable chemical properties, it is favored in industries that require these characteristics. However, besides the benefits that N-Butyl formate brings, it is necessary to be aware of the potential risks to workers’ health when in direct contact with this chemical for long periods without appropriate protective measures.
| No. | Chemical Name in Vietnamese | Chemical Name in English | HS Code | CAS Number | Chemical Formula |
| 1. | N-butyl format | N-Butyl formate | 29151300 | 592-84-7 | C5H10O2 |
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2. Where does N-Butyl formate originate from in the production process?
This organic compound often arises from various sources during the production process, especially in industries related to paints, printing inks, and synthetic plastics. One of the main sources of generation is the process of using this chemical as a solvent. When used in spray painting or surface coating systems, N-Butyl formate evaporates quickly and disperses into the air, creating a work environment with high concentrations of chemical vapor.
In addition, N-Butyl formate can also be generated from the production or preparation of other chemical compounds. During this process, without a strict control system, leakage or vapor escape of N-Butyl formate is difficult to avoid. Poor ventilation systems, technical failures, or improper machine operation can also lead to the chemical’s dispersal into the work environment.
Besides, operations related to the transport, storage, and handling of N-Butyl formate in containers or large tanks can also be a source of generation when the chemical is not stored properly. This poses a potential hazard to workers, especially in manufacturing plants that do not strictly adhere to safety procedures.

3. Industries that use N-Butyl formate in production
N-Butyl formate is widely used in many different industries thanks to its strong solvent properties and rapid evaporation rate. One of the most common industries is the paint industry, where N-Butyl formate is used to thin and quickly dry surface coatings. With its ability to effectively dissolve other compounds, this chemical helps improve the adhesion and smoothness of the paint layer, while shortening drying time, optimizing the production process.
In addition, N-Butyl formate is also applied in the printing ink industry, where it acts as a solvent to create inks with high volatility, helping the ink dry quickly on the printing surface. This is particularly important in high-speed printing processes, where it is necessary to ensure that the ink does not smudge or blur after printing. The synthetic plastics industry also uses N-Butyl formate in the manufacturing and processing of various plastics and polymers, thanks to its ability to facilitate the processing of raw materials.
Furthermore, the flavoring and fragrance industry also uses N-Butyl formate due to the pleasant fruity scent this chemical provides. It is often used to create natural or synthetic flavors, serving the production of cosmetics and personal care products. Despite its many useful applications, the use of N-Butyl formate requires strict adherence to occupational safety regulations to protect the health of workers in the work environment.
4. How does N-Butyl formate affect workers?
N-Butyl formate can cause many negative impacts on workers’ health when exposed frequently or in environments with high concentrations. This chemical is volatile and enters the body through the respiratory tract, skin, and eyes. When exposed via the respiratory tract, N-Butyl formate can irritate the nose, throat, and lungs, leading to symptoms such as coughing, shortness of breath, and a burning sensation in the chest. In severe cases, inhaling large amounts of N-Butyl formate vapor over a long period can lead to lung and respiratory system damage.
When in direct contact with the skin, N-Butyl formate can cause dryness, irritation, and even dermatitis if no protective measures are taken. In particular, workers who handle or come into contact with this chemical for long periods are at high risk of developing skin diseases. If the chemical comes into contact with the eyes, it can cause redness, irritation, and in more severe cases, corneal damage.
In addition, when N-Butyl formate is absorbed into the body at high concentrations, it can affect the nervous system, causing symptoms such as dizziness, headache, nausea, and loss of concentration. These symptoms can reduce work productivity and increase the risk of occupational accidents.
To minimize the harmful effects of N-Butyl formate, adhering to occupational safety procedures is essential. Workers should be fully equipped with personal protective equipment such as masks, safety glasses, and gloves, and work in an environment with a good ventilation system to minimize the risk of exposure to this chemical.
5. Permissible safe concentration of N-Butyl formate for human exposure
The safe concentration of N-Butyl formate for human exposure is strictly regulated to ensure worker health in industrial environments. According to international occupational safety standards, the maximum permissible concentration of N-Butyl formate in the workplace air should not exceed 100 ppm (parts per million) over a continuous 8-hour workday. This is the concentration level considered safe, helping to minimize negative health impacts when breathing or coming into direct contact with this chemical.
However, in some special cases, when workers must work in environments with higher concentrations of N-Butyl formate, additional protective measures are necessary. For example, when the N-Butyl formate concentration exceeds 150 ppm, workers should use respiratory protection equipment such as chemical vapor filter masks or an effective industrial ventilation system to prevent inhalation of the chemical. At the same time, the concentration of N-Butyl formate in the air should be regularly checked and monitored using specialized measuring devices to ensure it does not exceed the permissible safe limit.
In addition, regulations regarding the duration of exposure to N-Butyl formate must also be strictly followed. Workers should not be exposed to high concentrations for long periods without rest breaks or leaving the chemical-containing environment. Maintaining a safe concentration level and implementing risk control measures are important to protect workers’ health and prevent serious consequences caused by N-Butyl formate.

At a basic level, if working in an industrial environment, adhering to safety standards and limiting exposure to N-butyl formate is important. Organizations like the Occupational Safety and Health Administration (OSHA) in the United States provide guidelines and safety principles to protect workers from the negative impacts of chemicals.
6. Measures to minimize the impact of N-Butyl formate on worker health
To minimize the impact of N-Butyl formate on worker health, it is necessary to apply many protective measures and strict controls during the work process. First and foremost, providing a good ventilation system in the workplace is a crucial factor. This system helps remove N-Butyl formate vapors from the air, reducing the chemical concentration and limiting workers’ inhalation throughout the work process. Factories and production workshops should install natural ventilation systems or use industrial exhaust fans and air filters.
Equipping workers with adequate personal protective equipment (PPE) is another essential measure. Workers must be equipped with chemical vapor filter masks, safety glasses to protect the eyes, and chemical-resistant gloves to prevent direct skin contact. For environments with N-Butyl formate concentrations higher than the permissible level, specialized respiratory protection equipment should be used to protect the respiratory system.
In addition, training and raising awareness for workers about the risks of N-Butyl formate is also very important. Workers need to understand safety measures, procedures for working with this chemical, and how to respond in case of an incident related to leakage or overexposure to N-Butyl formate. Regular training programs will help workers grasp the necessary knowledge and skills to ensure safety.
Furthermore, factories should use automated tools and equipment to minimize workers’ direct contact with N-Butyl formate. Applying devices to measure and monitor chemical concentrations in the air is also an effective preventive measure, ensuring the work environment always remains within safe thresholds.
Finally, emergency control measures must be in place in case of leakage or incidents related to N-Butyl formate. Emergency response plans need to be readily available, including alarm systems, evacuation instructions, and first aid medical equipment to minimize health damage to workers.
Occupational safety and health training: Workers need to be trained and educated about the risks and safety measures when working with this type of chemical. This training needs to be provided periodically and regularly to ensure understanding and proper compliance with safety rules.
Periodically organize workplace environment monitoring in factories and enterprises, collect and analyze factors harmful to workers, thereby adjusting to reduce hazard levels to prevent occupational diseases for them.
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