N-Butyl isocyanate (C5H9NO) is an industrial chemical that can cause many serious health problems for workers. This article will help you better understand its effects on health, dangerous symptoms, and effective protective measures when working in an environment exposed to this chemical.
1. What is N-Butyl isocyanate?
The chemical formula C5H9NO represents an organic compound with a rather special structure, consisting of carbon (C), hydrogen (H), nitrogen (N), and oxygen (O) atoms. This chemical is a type of isocyanate, featuring the characteristic isocyanate group (-NCO) in its molecular structure, which gives it strong reactive properties.
In industry, this compound is mainly used in the production of plastics, rubber, and polyurethane materials. Thanks to the special properties of the isocyanate group, it can react with other substances to form highly durable polymers, increasing its applicability in various industries.
However, the presence of the isocyanate group also poses some risks to human health, especially for workers who work directly with this chemical. Therefore, a clear understanding of the nature and properties of this compound is essential to ensure safety during its production and use.
| No. | Chemical Name in Vietnamese | Chemical Name in English | HS Code | CAS Number | Chemical Formula |
| 1. | N-Butyl isoxyanat | N-Butyl isocyanate | 29291090 | 111-36-4 | C5H9NO |
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2. Where does N-Butyl isocyanate originate from in the production process?
During the production of products containing polyurethane, rubber, plastic, or other materials using this chemical, it is often generated during processing stages, chemical reactions, or when carrying out the polymerization process. Specifically, this compound appears when precursors, such as butyl alcohol or other derivatives, react with raw materials containing the isocyanate group.
Additionally, in industrial plants producing paints, coatings, or construction products, N-Butyl isocyanate can also be formed during the mixing and processing of chemical components. When these substances come into contact with each other under appropriate temperatures and conditions, a chemical reaction will produce the N-Butyl isocyanate compound, which can be released into the air, increasing the potential for worker exposure to this hazardous chemical.
Furthermore, in polyurethane production lines, the reaction process between isocyanates and polyols (such as polyether or polyester) also leads to the formation and release of N-Butyl isocyanate, especially when this process is incomplete or not well-controlled.

3. Industries that use N-Butyl isocyanate in production
Many industries use this compound in their production processes due to its special properties in creating highly durable materials. One of the industries that uses this chemical the most is polyurethane production. This is a material widely used in sectors such as the manufacturing of insulation materials, construction materials, furniture, and automotive parts. In polyurethane manufacturing plants, N-Butyl isocyanate is one of the key components that helps create the necessary polymers.
The paint and coatings industry is another field that uses this chemical, especially in the formulation of waterproof or heat-resistant paints. N-Butyl isocyanate can react with polyols to create durable coatings, helping to protect material surfaces from corrosion, weathering, and other environmental factors.
In addition, in the rubber manufacturing industry, N-Butyl isocyanate is used to create heat-resistant rubbers and other flexible materials. This chemical helps improve the mechanical properties of rubber, increasing its strength, flexibility, and abrasion resistance.
The wood processing, construction materials, and plastics manufacturing industries may also come into contact with N-Butyl isocyanate during the production of composite materials, wall panels, or products made from rigid plastics. This chemical plays an important role in enhancing the strength and stability of the final product.
4. How does N-Butyl isocyanate affect workers?
When workers are exposed to this chemical during the production process, it can cause many negative health effects. Due to the highly reactive nature of the isocyanate group, this compound can cause direct irritation to the respiratory system, eyes, and skin. People working in environments with high concentrations of N-Butyl isocyanate are prone to symptoms such as coughing, shortness of breath, rhinitis, pharyngitis, and other lung problems. In severe cases, long-term exposure to this chemical can lead to occupational asthma or chronic respiratory diseases.
Besides respiratory issues, this chemical can also cause skin irritation, leading to rashes, itching, and contact dermatitis. In particular, people with sensitive skin or who have been exposed to other chemicals during their work are more likely to experience severe skin reactions. Moreover, without proper protective measures, workers could suffer acute poisoning if they inhale N-Butyl isocyanate gas for a prolonged period.
In addition, continuous exposure to this chemical can also affect the nervous system. Some studies indicate that if workers are exposed to N-Butyl isocyanate for a long time, they may experience neurological problems such as headaches, dizziness, nausea, or even more serious issues like central nervous system disorders.
5. Permissible safe concentration of N-Butyl isocyanate for human exposure
To ensure worker safety when working in an environment where N-Butyl isocyanate is present, regulating a safe concentration in the air is very important. International occupational safety organizations such as OSHA (U.S. Occupational Safety and Health Administration) and ACGIH (American Conference of Governmental Industrial Hygienists) have set permissible exposure limit standards to protect the health of workers.
According to these guidelines, the maximum safe concentration of N-Butyl isocyanate in the workplace air is regulated not to exceed 0.02 ppm (parts per million) over an 8-hour work shift. This is the concentration level considered safe for workers to work without facing serious health risks from long-term exposure to this chemical.
In addition, countries and regions may have different specific regulations regarding permissible safe concentrations, depending on the conditions and specifics of each industry.

At a basic level, when working in an industrial environment, it is important to adhere to safety standards and limit exposure to N-Butyl isocyanate. Organizations such as the Occupational Safety and Health Administration (OSHA) in the United States provide guidelines and safety principles to protect workers from the negative impacts of chemical substances.
6. Measures to minimize the impact of N-Butyl isocyanate on workers’ health
To minimize the impact of N-Butyl isocyanate on workers’ health, protective and environmental control measures in the workplace are essential. First and foremost, improving ventilation in production areas is a crucial measure. An effective ventilation system helps to dilute and remove hazardous gases, including N-Butyl isocyanate, from the air, thereby minimizing the risk of exposure for workers.
In addition, the use of personal protective equipment (PPE) is an indispensable factor. Workers must be fully equipped with specialized air-purifying respirators, protective gloves, and safety goggles to minimize direct contact with the chemical. This equipment helps prevent the chemical from entering through the respiratory tract and skin, protecting workers from both short-term and long-term harm.
Training and raising awareness among workers about the potential risks of working with N-Butyl isocyanate is also an important measure. Workers need to be given detailed instructions on how to use protective equipment, recognize the signs of exposure, and know how to respond promptly in case of an incident.
Furthermore, monitoring and testing the concentration of N-Butyl isocyanate in the air is an essential step in controlling exposure levels. Tools for measuring the concentration of this chemical help to accurately determine the safety level at the workplace, allowing for timely adjustments, such as increasing ventilation or reducing workers’ exposure time.
Finally, production facilities must comply with health and occupational safety regulations, implement environmental hygiene measures in the workplace, and handle chemical waste properly. This not only helps to minimize health risks but also creates a safe and sustainable working environment for employees.
Occupational safety training: Workers need to be trained and educated on the risks and safety measures when working with this type of chemical. This training should be provided periodically and regularly to ensure understanding and proper compliance with safety rules.
Periodically organize occupational environment monitoring in factories and enterprises, collect and analyze factors harmful to workers, and thereby adjust to reduce hazard levels to prevent occupational diseases for them.
7. National Occupational Environment Monitoring Center
Nam Viet’s Occupational Environment Monitoring Center is a professional unit specializing in monitoring and measuring the quality of the working environment across all provinces in Vietnam. With a team of experienced monitoring specialists, the center uses modern measuring equipment to ensure accuracy and reliability.
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In addition to providing monitoring services, the center also assists clients in planning, handling, and tracking issues related to the occupational environment. With the motto “the customer is the center,” the center focuses on customer satisfaction, meets all customer needs, and is committed to providing the best solutions for businesses.
With investment in techniques, technology, and human resources, Nam Viet’s monitoring center has become one of the reputable units in the field of occupational environment monitoring in Ho Chi Minh City with the following objectives:
- We always value our brand reputation and the quality of our products and services.
- We provide our customers with the best and most suitable solutions possible.
- With a team of experienced and specialized Masters and Engineers, we aim to protect the environment and benefit businesses.

- By choosing the Nam Viet Environmental Monitoring team, your company will receive professional service from experts in the monitoring field. You will also receive the best cost incentives.
8. Quotation for Occupational Environment Monitoring
To help businesses conduct occupational environment monitoring professionally and effectively, Nam Viet provides our customers with a quality and reasonably priced quotation for occupational environment monitoring services.
- Our monitoring quotation provides detailed information on the pricing of the monitoring services we offer. This includes costs related to travel, measurement, analysis, and reporting of results. Customers can be completely assured of the accuracy and reliability of the monitoring result reports we provide.
- We are committed to always offering the most competitive and reasonable prices on the market, and we are also always ready to provide consultation and answer any questions about our monitoring services quickly and professionally.
- With Nam Viet’s monitoring quotation, customers can easily choose service packages that suit their needs. We are committed to bringing our customers the highest satisfaction with professional quality service.

