N-methyl acetamide (C3H7NO) is a chemical commonly used in production, but it can cause serious health effects for workers if not managed properly. Let’s explore the impact of N-methyl acetamide on health and effective protective measures in this article.
1. What is N-methyl acetamide?
The chemical formula C3H7NO represents an organic compound with a structure containing three carbon atoms, seven hydrogen atoms, one nitrogen atom, and one oxygen atom. This compound belongs to the amide group, with an amide functional group (-CONH) attached to a methyl group (-CH3) via a bond to the carbon atom.
This substance is a common solvent in many industrial processes, especially in the production of pharmaceuticals, dyes, and plastics. It has good solubility with many organic compounds and can increase the solubility of substances that are poorly soluble in water. This characteristic allows N-methyl acetamide to be widely used in the chemical, pharmaceutical, and synthetic chemistry industries.
As a colorless liquid, N-methyl acetamide has a mild odor, is volatile, and can cause irritation upon direct contact with the skin or eyes.
| No. | Chemical Name in Vietnamese | Chemical Name in English | HS Code | CAS Number | Chemical Formula |
| 1. | N-Metyl axetamit | N-methyl acetamide | 29241900 | 79-16-3 | C3H7NO |
See more chemical safety training services according to Decree 113/2017/ND-CP
REGISTER FOR CHEMICAL OCCUPATIONAL SAFETY TRAINING ACCORDING TO DECREE 113
2. Where does N-methyl acetamide originate from in the production process?
During the production process, this compound can be generated from various sources, mainly related to stages using solvents or chemicals containing the amide group. In factories producing pharmaceuticals, plastics, and other chemical products, this compound is often used as a solvent in chemical synthesis. When chemical reactions occur, compounds containing N-methyl acetamide can be created from raw materials or during the processing of intermediate chemicals.
In addition, in the dyeing, painting, or pharmaceutical industries, when organic substances are processed at high temperatures or in the presence of chemical reactions, this compound can also be generated. The improper use and storage of chemicals in the production environment can lead to the release of this compound into the air or onto product surfaces, creating a risk of exposure for workers.

3. Industries that use N-methyl acetamide in production
This compound is used in many different industries, especially in the chemical and pharmaceutical manufacturing sectors. In the pharmaceutical industry, it is used as a solvent in the synthesis of various drugs, helping to dissolve water-insoluble components and increase the efficiency of chemical reactions. This is particularly important in the production of drugs with high biological activity, which require solvents with good solubility and stability.
In the plastics industry, this compound is also used as a solvent in polymer synthesis processes, helping to improve the miscibility of substances during plastic manufacturing. In particular, it is found in the production of flexible plastics, synthetic resins, and materials with high applicability in consumer fields.
In addition, in the dye and paint industry, this compound is also a key component. It helps dissolve colorants and other chemical compounds in the production of paints, printing inks, as well as surface decoration products. Furthermore, this compound is also used in other chemical processing industries, especially in the production of organic compounds with high applicability in the electronics and manufacturing industries.
4. How does N-methyl acetamide affect workers?
When workers are exposed to this compound during the production process, it can cause serious health effects. Studies indicate that inhaling or having direct contact with this substance can lead to respiratory problems, including coughing, shortness of breath, and pneumonia. In work environments with high concentrations, workers may experience irritation of the nasal, throat, and eye mucous membranes, causing a burning sensation or tearing.
Furthermore, long-term exposure to this compound can affect the central nervous system. Workers may feel tired, dizzy, have headaches, or even lose their ability to concentrate, affecting productivity and work efficiency. These symptoms often appear when there is an accumulation of this compound in the body due to long-term exposure or lack of appropriate protective measures.
This compound can also be harmful to the liver and kidneys if not treated promptly. When absorbed through the skin or respiratory tract, it can accumulate in these organs, causing long-term damage. People working in industries that use this compound, such as pharmaceuticals, plastics, and paint manufacturing, need to pay special attention to health protection measures such as wearing masks, gloves, and having good ventilation in the work area.
5. Permissible safe concentration of N-methyl acetamide for human exposure
To protect the health of workers when working with this compound, occupational safety regulatory agencies have established standards for the permissible safe concentration that workers can be exposed to without facing serious harm. This concentration is usually specified for long-term and short-term exposure levels to ensure that workers are not adversely affected during their work.
According to the safety guidelines of OSHA (U.S. Occupational Safety and Health Administration), the concentration of N-methyl acetamide in the air should not exceed 10 ppm (parts per million) for a continuous hour of work. This is the permissible concentration in the work environment, helping to minimize the risk of damage to the respiratory system and other organs of the body. However, to ensure absolute safety, experts recommend that the actual concentration in work areas should be lower than this level, and measures for emission control and good ventilation are necessary.
In addition, studies also show that N-methyl acetamide concentrations higher than the specified level can cause adverse health effects even in a short period.

At a basic level, when working in an industrial environment, it is important to adhere to safety standards and limit exposure to N-methyl acetamide. Organizations such as the Occupational Safety and Health Administration (OSHA) in the United States provide guidelines and safety principles to protect workers from the negative impacts of chemical substances.
6. Measures to minimize the impact of N-methyl acetamide on workers’ health
To minimize the impact of this compound on workers’ health, protective measures and control of the work environment are essential. One of the most important methods is to control the chemical concentration in the air, ensuring it does not exceed the permissible safe level. Natural or mechanical ventilation systems should be adequately installed in production areas to limit the accumulation of the chemical in the air. Maintaining good air circulation not only helps to reduce the concentration of N-methyl acetamide but also reduces the risk of long-term exposure for workers.
In addition, providing personal protective equipment for workers is an indispensable measure. Workers should be fully supplied with protective equipment such as chemical-resistant masks, gloves, safety glasses, and protective clothing. This equipment helps prevent direct contact with the compound and protects the skin, eyes, and respiratory tract from the negative effects of the chemical.
Training and raising awareness among workers is also a crucial factor in minimizing risk. Training sessions should be organized on how to recognize and handle chemical-related incidents and to apply safety procedures correctly. This not only helps workers to be more effective but also ensures they can protect their own health throughout the production process.
Furthermore, regular health check-ups for workers are necessary to detect early signs of diseases related to chemical exposure. Regular tests and health examinations help to promptly identify adverse effects on the liver, kidneys, and nervous system, allowing for timely intervention.
Finally, replacing N-methyl acetamide with less toxic chemicals, if possible, is a long-term solution that helps minimize the risk of exposure and sustainably protect workers’ health.
Occupational safety training: Workers need to be trained and educated on the risks and safety measures when working with this type of chemical. This training should be provided periodically and regularly to ensure understanding and proper compliance with safety rules.
Periodically organize occupational environment monitoring in factories and enterprises, collect and analyze factors harmful to workers, and thereby adjust to reduce hazard levels to prevent occupational diseases for them.
7. National Occupational Environment Monitoring Center
Nam Viet’s Occupational Environment Monitoring Center is a professional unit specializing in monitoring and measuring the quality of the working environment across all provinces in Vietnam. With a team of experienced monitoring specialists, the center uses modern measuring equipment to ensure accuracy and reliability.
REGISTER FOR OCCUPATIONAL ENVIRONMENT MONITORING SERVICES
In addition to providing monitoring services, the center also assists clients in planning, handling, and tracking issues related to the occupational environment. With the motto “the customer is the center,” the center focuses on customer satisfaction, meets all customer needs, and is committed to providing the best solutions for businesses.
With investment in techniques, technology, and human resources, Nam Viet’s monitoring center has become one of the reputable units in the field of occupational environment monitoring in Ho Chi Minh City with the following objectives:
- We always value our brand reputation and the quality of our products and services.
- We provide our customers with the best and most suitable solutions possible.
- With a team of experienced and specialized Masters and Engineers, we aim to protect the environment and benefit businesses.

- By choosing the Nam Viet Environmental Monitoring team, your company will receive professional service from experts in the monitoring field. You will also receive the best cost incentives.
8. Quotation for Occupational Environment Monitoring
To help businesses conduct occupational environment monitoring professionally and effectively, Nam Viet provides our customers with a quality and reasonably priced quotation for occupational environment monitoring services.
- Our monitoring quotation provides detailed information on the pricing of the monitoring services we offer. This includes costs related to travel, measurement, analysis, and reporting of results. Customers can be completely assured of the accuracy and reliability of the monitoring result reports we provide.
- We are committed to always offering the most competitive and reasonable prices on the market, and we are also always ready to provide consultation and answer any questions about our monitoring services quickly and professionally.
- With Nam Viet’s monitoring quotation, customers can easily choose service packages that suit their needs. We are committed to bringing our customers the highest satisfaction with professional quality service.

