N-Propyl isocyanate (C4H7ON) is a chemical commonly used in manufacturing plants, but what is its effect on the health of workers? This article will analyze the health risks, symptoms of poisoning, and the necessary protective measures to ensure effective occupational safety.
1. What is N-Propyl isocyanate?
N-Propyl isocyanate, with the chemical formula C4H7ON, is an organic compound belonging to the isocyanate group. This is a toxic chemical and is mainly used in the manufacturing industry. N-Propyl isocyanate has a chemical structure that includes an isocyanate group (-NCO) bonded to a propyl chain.
This chemical exists as a colorless liquid with a characteristic odor, and is often used as a raw material in the synthesis of other organic compounds or in the production of polymer and plastic products. However, the chemical properties of N-Propyl isocyanate make it a strong irritant to the human respiratory system, skin, and eyes.
A clear understanding of N-Propyl isocyanate not only helps in identifying and controlling risks in the work environment but also plays a crucial role in establishing appropriate safety measures. Therefore, having a firm grasp of information about this chemical is essential for both workers and managers in related industries.
| No. | Chemical Name in Vietnamese | Chemical Name in English | HS Code | CAS Number | Chemical Formula |
| 1. | N-Propyl isoxyanat | N-Propyl isocyanate | 29291090 | 110-78-1 | C4H7ON |
See more services: chemical safety training according to Decree 113/2017/NĐ-CP
REGISTER FOR CHEMICAL OCCUPATIONAL SAFETY TRAINING ACCORDING TO DECREE 113
2. Where does N-Propyl isocyanate originate from in the production process?
The organic compound N-Propyl isocyanate primarily originates from industrial production processes related to chemicals and polymers. During production, this compound is synthesized from the reaction between propyl alcohol and carbon dioxide under special catalytic conditions. This is a crucial step in the manufacturing of polymer products, plastics, and other organic compounds.
This chemical is commonly used in processing and manufacturing industries such as the production of polyurethane plastics, paints, and additives for the textile industry. In manufacturing plants, N-Propyl isocyanate can be generated from the process of chemical treatment and conversion, especially when isocyanate-containing raw materials are used or when there is incomplete decomposition of these compounds.
The generation of N-Propyl isocyanate can occur during production steps or equipment maintenance, and it often occurs as a gas or vapor, which easily disperses in the air. Therefore, controlling and managing this source of emission is very important to ensure the safety of workers and the work environment. Measures such as using effective ventilation systems, personal protective equipment, and periodic inspection procedures can help minimize the risk of exposure to this toxic chemical.

3. Industries that use N-Propyl isocyanate in production
N-Propyl isocyanate is used in many different industries and production fields due to its chemical properties. One of the main industries that use N-Propyl isocyanate is the polyurethane plastic manufacturing industry. Polyurethane is a type of plastic with superior mechanical properties and is widely used in products such as cushions, surface coatings, and insulation materials. In the polyurethane production process, N-Propyl isocyanate plays an important role in creating the necessary chemical bonds, thereby producing plastic products with high technical characteristics.
In addition, N-Propyl isocyanate is also used in the paint and surface coating industry. In this industry, this chemical helps improve the adhesion and durability of paint. This makes it an important component in the production of industrial paints, automotive paints, and decorative paints, ensuring that the final product has high quality and durability.
The textile industry is another field that has applications for N-Propyl isocyanate. In the process of treating fabrics and fibers, this chemical is used to enhance the properties of the product, such as wrinkle resistance and water repellency. This helps improve the quality of textile products and makes them more suitable for market needs.
Along with that, N-Propyl isocyanate is also used in other industries related to the production of chemicals and additives. These applications allow for the production of products with special properties, suitable for the technical and quality requirements of each industry.
4. How does N-Propyl isocyanate affect workers?
N-Propyl isocyanate has a significant impact on the health of workers, especially with long-term exposure or at high concentrations. This chemical has the ability to cause strong irritation to the respiratory system, skin, and eyes. When inhaling the vapor or gas of N-Propyl isocyanate, workers may experience symptoms such as coughing, shortness of breath, and chest pain. These symptoms can lead to pneumonia or more serious respiratory problems if not treated promptly.
Direct contact with the skin can also cause severe irritation, including redness, itching, and blistering. In some cases, allergic reactions or prolonged sensitivity may occur. When this chemical gets into the eyes, it can cause keratitis, redness, and a burning sensation, and seriously affect vision if not treated quickly.
In addition to acute health problems, long-term exposure to N-Propyl isocyanate can cause more serious issues. Some studies show that prolonged exposure can lead to chronic diseases such as chronic bronchitis or chronic obstructive pulmonary disease (COPD). People exposed to N-Propyl isocyanate for a long time also have a higher risk of developing cancers related to the respiratory system.
To minimize the negative impact of N-Propyl isocyanate, protective measures must be strictly implemented in the work environment. This includes the use of personal protective equipment such as gas masks, gloves, and safety glasses. An effective ventilation system and air quality management procedures are also very important in reducing the risk of exposure and protecting the health of workers.
Understanding the health effects of N-Propyl isocyanate and implementing protective measures are necessary to ensure the safety of workers and maintain a healthy work environment.
5. Permissible safe concentration of N-Propyl isocyanate for human exposure
The safe concentration of N-Propyl isocyanate for human exposure is regulated by standards and guidelines from occupational health and safety agencies. Organizations such as OSHA (the U.S. Occupational Safety and Health Administration) and ACGIH (the American Conference of Governmental Industrial Hygienists) issue maximum permissible exposure limits to protect worker health.
According to international standards, the permissible exposure limit of N-Propyl isocyanate in the workplace air is often determined by the PEL (Permissible Exposure Limit) and TLV (Threshold Limit Value) indices. For N-Propyl isocyanate, the maximum concentration limit in the air is typically set at about 0.01 ppm (parts per million) for an 8-hour workday, and the maximum concentration should not exceed 0.05 ppm for shorter periods.
However, these regulations may vary depending on the country and the health regulatory agency. Therefore, companies and organizations must comply with the specific guidelines applicable in their country and conduct periodic checks to ensure that the concentration of N-Propyl isocyanate does not exceed the permissible level.
To maintain the chemical concentration within safe limits, controlling air quality and using an effective ventilation system are very important. At the same time, personal protective measures such as gas masks and protective equipment should be applied to minimize the risk of direct contact with the chemical.

On a basic level, if working in an industrial environment, adhering to safety standards and limiting exposure to N-Propyl isocyanate is important. Organizations like the Occupational Safety and Health Administration (OSHA) in the United States provide guidelines and safety principles to protect workers from the negative impacts of chemical substances.
6. Measures to minimize the effects of N-Propyl isocyanate on workers’ health
To minimize the effects of N-Propyl isocyanate on workers’ health, preventive and control measures must be strictly implemented in the work environment. One of the most important measures is to improve the ventilation system in the work area. Ensuring good ventilation helps remove N-Propyl isocyanate vapor and gas from the air, minimizing the risk of inhaling these toxic chemicals. The ventilation system should be designed to exhaust contaminated air and replace it with clean air, while ensuring that the air in the work area is always maintained at a safe concentration level.
Using personal protective equipment is another important measure to protect workers. Gas masks, protective gloves, and safety glasses are necessary equipment when working with N-Propyl isocyanate. Masks must be equipped with appropriate filters to block chemical vapors, while gloves and safety glasses help protect the skin and eyes from direct contact with the chemical. Ensuring that this protective equipment is always in good condition and used correctly is essential to minimize health risks.
Training and raising awareness for workers also play a crucial role in protecting their health. Workers need to be trained on the risks associated with N-Propyl isocyanate, how to use protective equipment correctly, and the necessary preventive measures to minimize exposure to the chemical. At the same time, organizing regular training sessions and periodic health checks for workers also helps to detect early signs of poisoning and to handle them in a timely manner.
Air quality management and the implementation of periodic checks are indispensable factors in minimizing the impact of N-Propyl isocyanate. Companies should conduct regular tests to measure the concentration of the chemical in the air, ensuring that the concentration does not exceed the safe limit. If a concentration exceeding the permissible level is detected, control measures must be adjusted immediately and the relevant employees must be notified.
Occupational safety training: Workers need to be trained and educated about the risks and safety measures when working with this type of chemical. This training should be provided periodically and regularly to ensure understanding and proper adherence to safety rules.
Periodically organize work environment monitoring in factories and enterprises, collecting and analyzing factors harmful to workers, thereby adjusting to reduce hazard levels to prevent occupational diseases for them.
7. National Work Environment Monitoring Center
The Work Environment Monitoring Center of Nam Viet is a professional unit for monitoring and measuring the quality of the work environment across all provinces in Vietnam. With a team of experienced monitoring specialists, the center uses modern measuring equipment, ensuring accuracy and reliability.
REGISTER FOR WORK ENVIRONMENT MONITORING SERVICES
In addition to providing monitoring services, the center also supports clients in planning, handling, and tracking work environment issues. With the motto “the customer is the center,” the center focuses on customer satisfaction, meeting all customer needs, and committing to providing the best solutions for businesses.
With investment in technology, equipment, and human resources, Nam Viet’s monitoring center has become one of the reputable units in the field of work environment monitoring in Ho Chi Minh City with the following objectives:
- We always value our brand reputation and the quality of our products and services.
- We provide our customers with the best and most suitable solutions possible.
- With a team of experienced Masters and Engineers with a desire to protect the environment and benefit businesses.

- With Nam Viet Environmental Monitoring team, your company will receive professional service from experts in the monitoring field. At the same time, you will get the best cost incentives.
8. Quotation for work environment monitoring
To help businesses conduct work environment monitoring professionally and effectively, Nam Viet offers our valued customers a price list for quality and reasonably priced work environment monitoring services.
- Our monitoring price list provides detailed information about the prices of the monitoring services we offer. This includes costs related to travel, measurement, analysis, and reporting of results. Customers can be completely assured of the accuracy and reliability of the monitoring result reports we provide.
- We are committed to always offering the most competitive and reasonable prices on the market, and we are also always ready to provide consultation and answer any questions about our monitoring services quickly and professionally.
- With Nam Viet’s monitoring price list, customers can easily choose service packages that suit their needs. We are committed to bringing our customers the highest satisfaction with our professional service quality.

