Perfluoroisobutene (C₄F₈) is a common chemical in industrial production, but few are aware that it can cause serious health effects for workers. Let’s explore the risks and necessary protective measures when working in an environment with exposure to this substance.
1. What is Perfluoroisobutene?
The chemical formula for Perfluoroisobutene is C₄F₈, representing a fluoro-organic compound, which consists of four carbon (C) atoms and eight fluorine (F) atoms. It is a colorless, odorless gas with high stability and the potential to cause serious harm if humans are exposed to it. This substance is often used in industries such as electronics, the production of insulating materials, and other industrial manufacturing applications. The molecular structure of C₄F₈ allows it to exist as a gas under normal conditions and it can easily diffuse in the air.
Unlike many other organic compounds, C₄F₈ does not easily decompose in the environment, which makes it a potential pollutant with long-term effects on human health. Therefore, a clear understanding of the structure and properties of this compound is very important for applying safety measures when it is used in industry.
| No. | Chemical Name in Vietnamese | Chemical Name in English | HS Code | CAS Number | Chemical Formula |
| 1. | Perflo isobuten (PFIB) | Perfluoroisobutene | 29033990 | 382-21-8 | C₄F₈ |
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2. What are the sources of Perfluoroisobutene in the production process?
The sources of C₄F₈ in the production process mainly come from chemical reactions that occur when fluorine-containing compounds are used in manufacturing. In many industries, especially in the field of electronic component fabrication, fluorinated substances are widely used for their high insulating and stability properties. However, during this process, C₄F₈ can be generated as a gas or vapor under special conditions, such as in chemical reactions using fluorine gas or other fluorine compounds.
In addition, C₄F₈ can also be formed during the processing of insulating materials, especially in environments with strong electric fields or high temperatures. While these processes are controlled to ensure product quality, they also produce emissions that include C₄F₈, posing a health risk to workers if appropriate protective measures are not in place.

3. Industries that use Perfluoroisobutene in production
C₄F₈ is widely used in many manufacturing industries, especially in fields requiring insulating materials and high-tech applications. One of the main industries that uses this compound is the production of electronic components, where C₄F₈ is applied in the fabrication processes of microcircuits, semiconductor devices, and other electronic parts. This compound is used to create a stable and insulating environment, ensuring the effective operation of electronic devices.
In addition, C₄F₈ also appears in the insulating material manufacturing industry, particularly in the production of cables and thermal insulation materials used in high-voltage electrical systems. This compound helps to enhance the insulating capacity and resistance to chemical agents and high temperatures during use.
Besides that, C₄F₈ is also applied in the medical industry, especially in diagnostic and treatment equipment, where it is used in measurement and optical devices. Optical technologies using C₄F₈ also help improve the accuracy and durability of the equipment, especially in environments requiring high stability.
4. How does Perfluoroisobutene affect workers?
Long-term exposure to C₄F₈ can cause many adverse health effects for workers, especially in production environments where the concentration of this substance is high. Although this compound is colorless and odorless, it can cause severe symptoms when inhaled or in direct contact with the skin. One of the most noticeable effects is on the respiratory system. When inhaling C₄F₈, workers may experience respiratory problems such as difficulty breathing, coughing, or irritation of the nasal and throat mucous membranes.
In addition, C₄F₈ can cause problems related to the nervous system. Symptoms such as dizziness, nausea, and fatigue may appear after exposure to this substance. in cases of long-term or high-concentration exposure, the effects on the central nervous system can become more severe, affecting the ability to work and the quality of life of the worker.
C₄F₈ can also cause skin and eye irritation if there is direct contact. Although it does not cause immediate burns, exposure to this gas can lead to a sensation of itching, skin redness, or conjunctivitis. If these phenomena occur and are not treated promptly, they can cause permanent damage.
5. Permissible safe concentration of Perfluoroisobutene for human exposure
The permissible safe concentration for human exposure to C₄F₈ is regulated based on the standards of international health and occupational safety organizations. Agencies such as OSHA (Occupational Safety and Health Administration) and ACGIH (American Conference of Governmental Industrial Hygienists) both issue safe exposure limits, which are usually measured by the concentration of the gas in the air. Accordingly, the safe concentration of C₄F₈ in the work environment should not exceed 1000 ppm (parts per million) during a standard 8-hour workday. However, this limit may vary depending on the regulations of each country and the type of work.
Although a safe concentration is regulated, it is still very important to maintain a well-ventilated work environment and to periodically check the concentration of C₄F₈ in the air.

On a basic level, if working in an industrial environment, it is important to comply with safety standards and limit exposure to Perfluoroisobutene (PFIB). Organizations such as the Occupational Safety and Health Administration (OSHA) in the United States provide guidelines and safety principles to protect workers from the negative effects of chemical substances.
6. Measures to mitigate the effects of Perfluoroisobutene on workers’ health
To minimize the health effects of C₄F₈ on workers, applying protective measures and controlling the work environment is extremely important. One of the most effective measures is to ensure the ventilation system in production areas using C₄F₈ is functioning well. The ventilation system not only helps to reduce the concentration of the gas in the air but also creates a well-ventilated workspace, helping to remove toxic gases and reduce the risk of exposure for workers.
Besides that, using personal protective equipment is an essential measure. Devices such as masks and respirators can filter the air and prevent C₄F₈ from coming into direct contact with the respiratory tract. In addition, gloves and protective clothing should also be used to protect the skin and eyes from the risk of irritation upon contact with this gas.
Periodic checking of the C₄F₈ concentration in the air is also an important measure to ensure the work environment remains safe. Gas concentration meters should be installed and used regularly to monitor the level of pollution in the production area. If the concentration is found to exceed the permissible limit, immediate mitigation measures must be taken, such as increasing ventilation or moving workers to a safe area.
Finally, training and raising awareness for workers about the risks and protective measures when working with C₄F₈ is very necessary. When they clearly understand the harms of this substance and how to prevent them, workers will be more proactive in complying with safety regulations and protecting their own health.
Occupational safety training: Workers need to be trained and educated on the risks and safety measures when working with this type of chemical. This training should be provided periodically and regularly to ensure understanding and proper adherence to safety rules.
Periodically organize occupational environment monitoring in factories and enterprises, to collect and analyze harmful factors for workers, thereby adjusting to reduce the level of harm to prevent occupational diseases for them.
7. National Occupational Environment Monitoring Center
The occupational environment monitoring center of Nam Viet is a professional unit specializing in monitoring and measuring the quality of the working environment across all provinces in Vietnam. With a team of experienced monitoring specialists, the center uses modern measuring equipment to ensure accuracy and reliability.
REGISTER FOR OCCUPATIONAL ENVIRONMENT MONITORING SERVICES
In addition to providing monitoring services, the center also supports clients in planning, handling, and tracking occupational environment issues. With the motto “the customer is the center,” the center focuses on customer satisfaction, meeting all customer needs, and is committed to providing the best solutions for businesses.
With investment in techniques, technology, and personnel, Nam Viet’s monitoring center has become one of the reputable units in the field of occupational environment monitoring in Ho Chi Minh City with the following objectives:
- We always value our brand reputation and the quality of our products and services.
- We provide our customers with the best and most suitable solutions possible.
- With a team of experienced Masters and Engineers, we aim to protect the environment and benefit businesses.

- With Nam Viet’s Environmental Monitoring team, your company will receive professional service from experts in the monitoring field. You will also get the best offers on costs.
8. Quotation for Occupational Environment Monitoring
To help businesses conduct occupational environment monitoring professionally and effectively, Nam Viet offers our valued customers a price list for quality and reasonably priced occupational environment monitoring services.
- Our price list for monitoring provides detailed information on the prices of the monitoring services we offer. This includes costs related to travel, measurement, analysis, and reporting of results. Customers can be completely assured of the accuracy and reliability of the monitoring result reports we provide.
- We are committed to always offering the most competitive and reasonable prices on the market, and we are also always ready to provide advice and answer any questions about our monitoring services quickly and professionally.
- With Nam Viet’s monitoring price list, customers can easily choose service packages that suit their needs. We are committed to bringing our customers the highest satisfaction with professional quality service.

