In the manufacturing industry, phthalic anhydride (C8H4O3) is an important chemical but also poses many potential risks to the health of workers. This article will help you better understand the health effects of phthalic anhydride, as well as the necessary measures to protect yourself when working in an environment with exposure to this chemical.
1. What is Phthalic anhydride?
Phthalic anhydride, with the chemical formula C8H4O3, is an organic compound belonging to the anhydride group, created from the oxidation of naphthalene or ortho-xylene. This compound typically appears as white crystals or a white powder, has a characteristic odor, and is readily soluble in some organic solvents such as benzene, toluene, and acetone.
Phthalic anhydride is widely used in many fields, especially in the plastics and paint manufacturing industries. It is the primary raw material for producing phthalate polymers, which act as plasticizers for products like plastic pipes, packaging materials, and many other industrial applications. In addition, phthalic anhydride is also used in the production of dyes, detergents, and other chemicals.
Despite its many industrial applications, phthalic anhydride also raises health concerns, especially for workers who come into contact with it. Therefore, a clear understanding of the nature and properties of this compound is crucial to apply appropriate safety measures when working in an environment where phthalic anhydride is used.
| No. | Chemical Name in Vietnamese | Chemical Name in English | HS Code | CAS Number | Chemical Formula |
| 1. | Phthalic anhydrit | Phthalic anhydride | 29173500 | 85-44-9 | C8H4O3 |
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2. Where does Phthalic anhydride originate from in the production process?
This organic compound is formed from various sources during industrial production. One of the main sources is the oxidation of naphthalene or ortho-xylene. In industry, naphthalene, an organic compound commonly extracted from crude oil, is processed in the presence of oxygen and catalysts to produce phthalic anhydride. This process typically occurs at high temperatures and pressures to ensure the reaction proceeds efficiently.
Besides naphthalene, ortho-xylene is also a common source for the generation of phthalic anhydride. Similar to naphthalene, ortho-xylene is also oxidized under controlled conditions to create this product. As the production process takes place, phthalic anhydride can be released into the air or water, depending on the plant’s waste treatment and management procedures.
Furthermore, during the use of products containing phthalic anhydride, such as plastics or paints, a small amount of phthalic anhydride may be generated from the decomposition or evaporation of these compounds. These sources not only affect the environment but also pose potential health risks to workers who are in direct contact with this chemical. Therefore, managing and controlling the sources of phthalic anhydride during production is crucial to minimize potential risks to health and the environment.

3. Industries that use Phthalic anhydride in production
This is an important chemical used in many different manufacturing industries. The plastics industry is one of the main sectors that uses phthalic anhydride. In plastics production, it is used to create phthalate polymers, a group of plasticizers that improve the properties of plastic, making products softer and more flexible. These plastic products are widely used in daily life, from household items to industrial equipment.
Besides the plastics industry, phthalic anhydride also plays a significant role in the paint and printing ink manufacturing sector. This compound is used as a colorant and a binding agent, helping to create paints with high adhesion and resistance to environmental impacts. This not only enhances product quality but also extends the lifespan of painted surfaces.
The chemical industry also uses phthalic anhydride in the production of other chemicals, including fragrances, dyes, and detergents. In addition, phthalic anhydride is used in the production of rubber products, thanks to its ability to improve the properties of rubber materials.
However, the use of phthalic anhydride in these industries also poses many challenges related to health and occupational safety. Workers who are in direct contact with phthalic anhydride during production are at high risk of being affected by health problems. Therefore, effective protective measures and occupational safety management are needed to minimize risks for workers in industries that use this chemical.
4. How does Phthalic anhydride affect workers?
Phthalic anhydride can affect workers’ health in various ways, especially those working in manufacturing industries that use this compound. When exposed to phthalic anhydride, workers may experience numerous health issues, ranging from mild symptoms to more severe effects.
One of the most noticeable impacts is skin and eye irritation. Phthalic anhydride can cause allergic reactions, leading to dermatitis or eye irritation. Symptoms may include itching, redness, or watery eyes. Additionally, when inhaling dust or vapor of phthalic anhydride, workers may experience respiratory difficulties, including coughing, shortness of breath, or irritation of the respiratory tract lining. These symptoms can be more severe for individuals with pre-existing respiratory conditions like asthma.
Beyond the short-term effects, phthalic anhydride also poses many long-term health risks. Research has indicated that long-term exposure to phthalic anhydride can lead to more serious problems such as chronic lung disease and even a higher risk of certain types of cancer. This is why occupational safety measures are extremely important in environments where phthalic anhydride is present.
Health and labor management organizations recommend that workers use personal protective equipment, such as masks and gloves, to minimize risks when working with phthalic anhydride. Furthermore, improving ventilation in work areas and training employees about the associated risks also play a crucial role in protecting workers’ health. By raising awareness and implementing safety measures, we can minimize the negative impact of phthalic anhydride on the health of the workforce.
5. Permissible safe concentration of Phthalic anhydride for human exposure
The permissible safe concentration of phthalic anhydride for human exposure is a critical factor in protecting the health of workers in industries that use this chemical. Health and labor management organizations have established maximum concentration limits that workers can be exposed to without adverse health effects.
According to safety standards, the concentration of phthalic anhydride in the workplace air is typically regulated at 0.3 mg/m³ over a continuous 8-hour work period. This is the level that studies have shown does not cause significant irritation symptoms or negative health effects. However, when the concentration exceeds this level, the risk of experiencing health problems increases significantly, including respiratory symptoms, skin, and eye irritation.
Furthermore, some studies also show that higher concentration levels, such as 1 mg/m³, can cause more severe allergic reactions and should be taken seriously in production environments. Therefore, regular monitoring of the phthalic anhydride concentration in the workplace air is very important to ensure it does not exceed the permissible level.
In addition to monitoring concentrations, implementing preventive measures such as improving ventilation, using personal protective equipment, and training employees on occupational safety should also be emphasized. When the concentration of phthalic anhydride is maintained at a safe level, risks can be minimized, and workers’ health can be more effectively protected. A clear understanding of safe concentrations and the implementation of preventive measures will contribute significantly to creating a safe and healthy work environment.

On a basic level, if working in an industrial environment, adhering to safety standards and limiting exposure to Phthalic anhydride is important. Organizations like the Occupational Safety and Health Administration (OSHA) in the United States provide guidelines and safety principles to protect workers from the negative impacts of chemical substances.
6. Measures to minimize the health effects of Phthalic anhydride on workers
To minimize the health effects of phthalic anhydride on workers, implementing safety measures is extremely necessary. One of the most effective measures is to improve ventilation in work areas where phthalic anhydride is used. Good ventilation will help dilute the concentration of the chemical in the air, minimizing the risk of inhaling dust or vapors from phthalic anhydride. Installing natural or mechanical ventilation systems can create a safer workspace for employees.
In addition, the use of personal protective equipment (PPE) also plays a crucial role in protecting workers’ health. Equipment such as masks, gloves, and safety goggles should be used regularly during work. This equipment not only helps prevent direct contact with phthalic anhydride but also reduces the risk of skin and respiratory irritation.
Training and raising awareness among workers about the risks associated with phthalic anhydride is also a necessary measure. Organizing occupational safety training courses, providing instructions on how to use personal protective equipment, and recognizing symptoms of exposure to phthalic anhydride will help workers be more proactive in protecting their own health.
Furthermore, regular monitoring of the phthalic anhydride concentration in the workplace air is also an important measure. Labor management organizations should conduct periodic checks to ensure that the concentration of this chemical does not exceed the permissible level. If high concentrations are detected, timely corrective measures must be taken to protect workers’ health.
Finally, businesses need to develop and implement safe work procedures, including the proper handling and storage of phthalic anhydride. These procedures not only help protect workers’ health but also contribute to creating a safe, healthy, and sustainable work environment. By combining these measures, the ability to minimize the health effects of phthalic anhydride on workers will be significantly improved.
Occupational safety training: Workers need to be trained and educated on the risks and safety measures when working with this type of chemical. This training should be provided periodically and regularly to ensure understanding and proper compliance with safety rules.
Periodically organize workplace environment monitoring in factories and enterprises, collecting and analyzing factors harmful to workers, thereby adjusting to reduce the hazard level to prevent occupational diseases for them.
7. National Workplace Environment Monitoring Center
The Workplace Environment Monitoring Center of Nam Viet is a professional unit specializing in monitoring and measuring the quality of the working environment across all provinces in Vietnam. With a team of experienced monitoring specialists, the center uses modern measuring equipment, ensuring accuracy and reliability.
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In addition to providing monitoring services, the center also supports clients in planning, handling, and tracking issues related to the working environment. With the motto “the customer is the center,” the center focuses on customer satisfaction, meeting all customer needs, and is committed to providing the best solutions for businesses.
With investment in techniques, technology, and human resources, the Nam Viet monitoring center has become one of the reputable units in the field of workplace environment monitoring in Ho Chi Minh City with the following objectives:
- We always value our brand reputation and the quality of our products and services.
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- With a team of experienced Masters and Engineers with a desire to protect the environment and benefit businesses.

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8. Quotation for workplace environment monitoring
To help businesses conduct workplace environment monitoring professionally and effectively, Nam Viet offers our customers a quotation for quality and reasonably priced workplace environment monitoring services.
- Our monitoring quotation provides detailed information on the prices of the monitoring services we offer. This includes costs related to travel, measurement, analysis, and reporting of results. Customers can be completely assured of the accuracy and reliability of the monitoring result reports we provide.
- We are committed to always offering the most competitive and reasonable prices on the market, and we are also always ready to provide consultation and answer any questions about monitoring services quickly and professionally.
- With Nam Viet’s monitoring quotation, customers can easily choose service packages that suit their needs. We are committed to bringing our customers the highest satisfaction with professional service quality.

