Propionyl chloride (C3H5OCl) is an important chemical in industry, but it also poses many risks to the health of workers. This article will help you understand the health effects of propionyl chloride, the symptoms to watch out for, and the necessary protective measures to ensure safety in the workplace. Let’s find out!
1. What is Propionyl chloride?
Propionyl chloride, with the chemical formula C3H5OCl, is an organic compound belonging to the acid anhydride group. Its molecular structure consists of three carbon atoms, five hydrogen atoms, one oxygen atom, and one chlorine atom. This substance typically exists as a liquid, is colorless, has a pungent odor, and is highly volatile, so it must be handled with care in production processes.
Propionyl chloride is widely used in the chemical industry as an intermediate to produce many other types of organic compounds. It is commonly used in the synthesis of esters, carboxylic acids, and other complex organic compounds. In addition, propionyl chloride is also applied in the pharmaceutical and cosmetics industries, and in the production of various polymers and plastics.
However, due to its toxic and irritant properties, the use of propionyl chloride requires strict adherence to occupational safety regulations. Exposure to this compound can cause many health problems for workers, thus emphasizing the importance of understanding it in the work environment.
| No. | Chemical Name in Vietnamese | Chemical Name in English | HS Code | CAS Number | Chemical Formula |
| 1. | Propionyl clorua | Propionyl chloride | 29159090 | 79-03-8 | C3H5OCl |
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2. Where does Propionyl chloride originate from in the production process?
In the production process, propionyl chloride is primarily created from the reaction between propionic acid and halogenating agents, usually thionyl chloride (SOCl2) or phosphorus pentachloride (PCl5). When these substances are mixed, a chemical reaction occurs, leading to the conversion of propionic acid into propionyl chloride, while releasing exhaust gases such as chlorine gas and other by-products. This process typically takes place under controlled temperature and pressure conditions to ensure optimal efficiency and minimize negative environmental impacts.
In addition, propionyl chloride can also appear as a by-product in some other chemical synthesis processes, especially in the production of complex organic compounds. The production of propionyl chloride at factories may involve the use of raw materials from various sources such as organic compounds containing carbon and hydrogen, and the use of halogenating chemicals in the process.

3. Industries that use Propionyl chloride in production
Propionyl chloride is widely used in many different industries due to its special chemical properties. One of the main fields that use propionyl chloride is the chemical industry. Here, this compound is often used as an intermediate in the synthesis of other organic compounds. It plays an important role in the production of esters, carboxylic acids, and many other complex compounds of industrial value.
In addition, propionyl chloride is also used in the pharmaceutical industry. Drug manufacturers often use this compound in the synthesis of active pharmaceutical ingredients, helping to improve treatment efficacy and meet market demands. The production of pharmaceutical chemicals requires high precision and quality, so propionyl chloride plays an essential role in providing the necessary raw materials.
The cosmetics industry is another area where propionyl chloride is present. In cosmetics production, this compound can be used to create ingredients that enhance the absorption and moisturizing capabilities of the product. This makes cosmetic products more effective, thereby attracting consumer interest.
Finally, propionyl chloride is also used in the polymer and plastics manufacturing industry. This compound is an important raw material in the production of plastics and polymers with special properties, meeting the diverse needs of the market. The flexibility in the application of propionyl chloride demonstrates its important role in the economy, while also requiring attention to safety measures to protect the health of workers during production.
4. How does Propionyl chloride affect workers?
Propionyl chloride is a toxic chemical compound, so exposure to it can cause many negative health effects for workers. When inhaling vapor or dust of propionyl chloride, workers may experience symptoms such as respiratory irritation, sore throat, cough, and difficulty breathing. People working in environments where this chemical is used often face respiratory problems, which can lead to chronic diseases if not treated promptly.
In addition, propionyl chloride can also cause skin and eye irritation. When in direct contact with the skin, this compound can cause allergic reactions, redness, itching, and even burns. For the eyes, contact can lead to conjunctivitis, severe damage to the cornea, and can cause vision loss if not treated in time. Therefore, the use of personal protective equipment such as gloves, goggles, and masks is extremely important to protect the health of workers.
Furthermore, studies show that prolonged exposure to propionyl chloride can have adverse effects on the nervous system and liver. Workers with frequent exposure may experience symptoms such as headaches, dizziness, and reduced concentration. Some studies also indicate that long-term exposure to this compound may lead to a higher risk of serious health problems such as liver disease and metabolic disorders.
5. Permissible safe concentration of Propionyl chloride for human exposure
Determining the permissible safe concentration of propionyl chloride for human exposure is very important to protect the health of workers in work environments where this chemical is used. Occupational safety and health regulatory agencies such as OSHA (Occupational Safety and Health Administration) and ACGIH (American Conference of Governmental and Industrial Hygienists) have issued standards for the maximum permissible concentration of propionyl chloride in the workplace air.
According to these guidelines, the safe concentration of propionyl chloride is typically set at 1 ppm (part per million) in the workplace air over an 8-hour period. This means that during a standard work period, the concentration of this compound should not exceed 1 part per million, to minimize health risks for workers. However, in some specific situations, such as in production processes that may generate higher concentrations, more stringent control measures are needed to protect health.
In addition, monitoring the work environment is also very important. Performing periodic checks of propionyl chloride concentration in the air will help to detect potential risks early and adjust preventive measures in a timely manner. Managers need to maintain a safe working environment by providing adequate personal protective equipment for workers, as well as organizing training sessions on chemical safety and how to handle emergency situations.
Although the permissible safe concentration has been established, each worker may have a different level of sensitivity to propionyl chloride. Therefore, monitoring individual health, including regular health checks and monitoring for related symptoms, is also an important part of ensuring safety for workers in environments where this chemical is used. By combining strict management and monitoring measures, risks can be minimized and worker health can be effectively protected.

On a basic level, if working in an industrial environment, adhering to safety standards and limiting exposure to Propionyl chloride is important. Organizations like the Occupational Safety and Health Administration (OSHA) in the United States provide guidelines and safety principles to protect workers from the negative impacts of chemical substances.
6. Measures to minimize the effects of Propionyl chloride on workers’ health
To minimize the effects of propionyl chloride on workers’ health, a series of comprehensive preventive measures should be applied. First, training and raising awareness for workers about the risks associated with propionyl chloride is extremely important. Workers need to clearly understand the chemical properties of this compound, the symptoms that may occur upon exposure, and how to use personal protective equipment effectively. Training programs should include practical lessons, helping workers to be confident and proactive in protecting themselves.
Second, the use of personal protective equipment (PPE) is an essential part of prevention. Companies need to provide adequate gloves, masks, safety glasses, and protective clothing for workers in environments containing propionyl chloride. Selecting PPE appropriate to the job characteristics and level of exposure to this chemical will help minimize the possibility of direct contact.
In addition, redesigning the work process is also very important. Measures such as improving ventilation, using toxic gas extraction systems, and designing closed processes can help reduce the concentration of propionyl chloride in the workplace air. This not only protects the health of workers but also improves the quality of the working environment.
Periodic monitoring of propionyl chloride concentration in the air is also an indispensable measure. Companies should conduct regular checks to ensure this concentration does not exceed the permissible safe level. If a high concentration is detected, emergency measures must be taken to minimize the risk to workers.
And regular health monitoring for workers is also very necessary. Companies should establish a system of regular health checks to detect early symptoms related to propionyl chloride exposure. If there are any abnormal signs, prompt intervention and treatment are needed.
Occupational safety training: Workers need to be trained and educated about the risks and safety measures when working with this type of chemical. This training should be provided periodically and regularly to ensure understanding and proper adherence to safety rules.
Periodically organize work environment monitoring in factories and enterprises, collecting and analyzing factors harmful to workers, thereby adjusting to reduce hazard levels to prevent occupational diseases for them.
7. National Work Environment Monitoring Center
The Work Environment Monitoring Center of Nam Viet is a professional unit for monitoring and measuring the quality of the work environment across all provinces in Vietnam. With a team of experienced monitoring specialists, the center uses modern measuring equipment, ensuring accuracy and reliability.
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In addition to providing monitoring services, the center also supports clients in planning, handling, and tracking work environment issues. With the motto “the customer is the center,” the center focuses on customer satisfaction, meeting all customer needs, and committing to providing the best solutions for businesses.
With investment in technology, equipment, and human resources, Nam Viet’s monitoring center has become one of the reputable units in the field of work environment monitoring in Ho Chi Minh City with the following objectives:
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- With a team of experienced Masters and Engineers with a desire to protect the environment and benefit businesses.

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8. Quotation for work environment monitoring
To help businesses conduct work environment monitoring professionally and effectively, Nam Viet offers our valued customers a price list for quality and reasonably priced work environment monitoring services.
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- With Nam Viet’s monitoring price list, customers can easily choose service packages that suit their needs. We are committed to bringing our customers the highest satisfaction with our professional service quality.

