Propyl chloroformate (C₄H₇ClO₂) is an important chemical in the manufacturing industry, but it poses potential risks to the health of workers. This article will help you better understand the effects of this substance on the human body when working in an environment where it is used.
1. What is Propyl chloroformate (Carbonochloridic acid, propyl ester)?
Propyl chloroformate (also known as Carbonochloridic acid, propyl ester) with the chemical formula C₄H₇ClO₂ is an organic compound containing carbon, chlorine, oxygen, and hydrogen. This substance belongs to the ester group of carbonochloridic acid, formed when carbonochloridic acid reacts with propanol (C₃H₇OH).
The chemical formula C₄H₇ClO₂ indicates that Propyl chloroformate consists of four carbon atoms, seven hydrogen atoms, one chlorine atom, and two oxygen atoms. In it, the propyl group (-C₃H₇) is attached to the -O-C(=O)-Cl group, creating the characteristic structure of a chloride ester. This substance is a transparent, volatile liquid with a characteristic odor.
Propyl chloroformate is mainly used in chemical industries such as the production of pharmaceuticals, plastics, and other organic compounds. With its strong chemical reactivity, it readily reacts with other substances, especially compounds containing amine or hydroxyl groups, to produce other organic derivatives.
Although it has many industrial applications, due to its strong chemical properties, Propyl chloroformate can also be hazardous to human health if not used correctly in the workplace.
| No. | Chemical Name in Vietnamese | Chemical Name in English | HS Code | CAS Number | Chemical Formula |
| 1. | Propyl cloformat | Propyl chloroformate (Carbonochloridic acid, propyl ester) | 29159090 | 109-61-5 | C4H7ClO2 |
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2. Where does Propyl chloroformate (Carbonochloridic acid, propyl ester) originate from in the production process?
During the production process, the origin of this substance mainly comes from chemical reactions related to the synthesis or processing of compounds containing amino or hydroxyl groups. The production of Propyl chloroformate usually begins with the combination of carbonochloridic acid with propanol. This reaction creates the propyl ester of carbonochloridic acid, while also generating propyl chloroformate as a by-product.
In addition, in some chemical industries, this substance may arise in chemical synthesis processes when raw materials or intermediate compounds react with chlorine-containing substances. Therefore, in manufacturing plants that use this chemical, exposure to Propyl chloroformate can occur throughout the synthesis, cleaning, or chemical processing stages.

3. Industries that use Propyl chloroformate (Carbonochloridic acid, propyl ester) in production
This substance is used in many different chemical and manufacturing industries. In the pharmaceutical industry, it plays an important role in the synthesis of organic compounds, especially drugs containing ester groups or other biologically active compounds. Reactions with Propyl chloroformate help create the organic derivatives necessary for the drug synthesis process.
In the plastics industry, especially polycarbonate and other polymers, this substance is also used to prepare necessary compounds. Propyl chloroformate participates in chemical reactions that help create ester bonds, thereby improving the mechanical properties of the plastic, increasing the durability and stability of the product.
The rubber industry also uses Propyl chloroformate to create compounds that have an effect in adjusting the properties of rubber, helping to improve the durability and resistance of the final product. Besides, in the industry of producing other chemical compounds such as solvents or detergents, this substance also has an important role in preparing products for industrial processes.
4. How does Propyl chloroformate (Carbonochloridic acid, propyl ester) affect workers?
When exposed to this chemical, workers may experience negative health effects, especially if safety precautions are not followed. Inhaling the vapor or dust of Propyl chloroformate can cause respiratory irritation, leading to coughing, difficulty breathing, or pneumonia. With prolonged exposure, these symptoms can become more severe and affect long-term health.
In addition, when in direct contact with the skin or eyes, this substance can cause skin irritation, redness, itching, or dermatitis. In cases of direct contact with large amounts, it can cause skin burns or severe eye damage. This chemical also has the ability to enter the body through the digestive tract or skin if not handled correctly, causing digestive problems or symptoms of poisoning.
In particular, with its strong chemical properties, Propyl chloroformate can cause damage to the central nervous system if a worker is exposed to high concentrations for a long time. Symptoms may include dizziness, headache, or nausea.
5. Permissible safe concentration of Propyl chloroformate (Carbonochloridic acid, propyl ester) for human exposure
The safe concentration of Propyl chloroformate for human exposure is mainly determined based on the occupational exposure limits set by health and occupational safety organizations. These limits define the concentration level of the chemical in the air that a worker can breathe without harm to their health throughout the workday.
According to international standards, the concentration of Propyl chloroformate in the air should not exceed 0.5 ppm (parts per million) over an 8-hour workday. This is the limit considered safe to minimize the risk of respiratory diseases or other health problems related to this chemical.
However, studies show that this concentration can vary depending on working conditions, duration of exposure, and the protective measures used by the worker.

On a basic level, if working in an industrial environment, adhering to safety standards and limiting exposure to Propyl chloroformate is important. Organizations like the Occupational Safety and Health Administration (OSHA) in the United States provide guidelines and safety principles to protect workers from the negative impacts of chemical substances.
6. Measures to minimize the health effects of Propyl chloroformate (Carbonochloridic acid, propyl ester) on workers
To minimize the health effects of this chemical on workers, safety measures in the workplace must be strictly applied. First, using an effective ventilation system in areas where Propyl chloroformate is used is very important. The ventilation system should be designed to ensure that toxic gases are continuously replaced, which helps to reduce the concentration of the chemical in the air and protect workers from inhaling chemical vapors.
Besides, workers should be fully equipped with personal protective equipment (PPE) such as respirators, protective gloves, safety goggles, and protective clothing to limit direct contact with the chemical. This equipment plays an important role in protecting the body from contact with Propyl chloroformate, especially when working in an environment with high chemical concentrations.
In addition, safe work procedures must also be strictly followed. Measures such as controlling air quality, using less toxic substitutes, and ensuring adequate training for workers on the potential risks and how to prevent them are essential. Regular health check-ups for workers are also an important measure to detect any abnormal signs early and prevent occupational diseases related to this chemical.
Occupational safety training: Workers need to be trained and educated on the risks and safety measures when working with this type of chemical. This training should be provided periodically and regularly to ensure understanding and proper compliance with safety rules.
Periodically organize occupational environment monitoring in factories and enterprises, collect and analyze factors harmful to workers, thereby adjusting to reduce the level of hazard to prevent occupational diseases for them.
7. National Occupational Environment Monitoring Center
Nam Viet’s Occupational Environment Monitoring Center is a professional unit for monitoring and measuring the quality of the working environment across all provinces in Vietnam. With a team of experienced monitoring specialists, the center uses modern measuring equipment, ensuring accuracy and reliability.
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In addition to providing monitoring services, the center also assists clients in planning, handling, and tracking occupational environment issues. With the motto “the customer is the center,” the center focuses on customer satisfaction, meets all customer needs, and is committed to providing the best solutions for businesses.
With investment in technology, engineering, and human resources, Nam Viet’s monitoring center has become one of the reputable units in the field of occupational environment monitoring in Ho Chi Minh City with the following objectives:
- We always value our brand reputation and the quality of our products and services.
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- With a team of experienced Masters and Engineers with a desire to protect the environment and benefit businesses.

- With the Nam Viet Environmental Monitoring team, your company will receive professional service from experts in the monitoring field. You will also get the best cost incentives.
8. Quotation for Occupational Environment Monitoring
To help businesses carry out occupational environment monitoring professionally and effectively, Nam Viet offers our customers a quality and reasonably priced quotation table for occupational environment monitoring services.
- Our quotation table provides detailed information about the prices of the monitoring services we offer. This includes costs related to travel, measurement, analysis, and reporting of results. Customers can be completely assured of the accuracy and reliability of the monitoring result reports we provide.
- We are committed to always offering the most competitive and reasonable prices on the market, and we are also always ready to provide advice and answer any questions about our monitoring services quickly and professionally.
- With Nam Viet’s quotation table, customers can easily choose service packages that suit their needs. We are committed to bringing our customers the highest satisfaction with professional service quality.

