In the context of an increasing number of manufacturing plants using the chemical safrole (C10H10O2), understanding the impact of this chemical on workers’ health has become urgent. This article will explore the potential effects of safrole, from health risks to necessary protective measures, to ensure worker safety.
1. What is Safrole?
The chemical formula C10H10O2 represents a naturally derived organic compound, often extracted from plants such as star anise, pepper, and some other plant species. This compound is known for its characteristic aroma and is commonly used in the food and perfume industries as a flavoring agent. Additionally, safrole is also used in the production of pesticides and some industrial chemicals.
In the structure of safrole, the two main functional groups, phenol and ether, create its unique properties. Studies have shown that safrole can stimulate certain enzymes in the body, which can affect metabolic processes and cause undesirable health effects, especially for workers who are regularly exposed to this chemical.
| No. | Chemical name in Vietnamese | Chemical name in English | HS Code | CAS Number | Chemical Formula |
| 1. | Safrol | Safrole | 29329400 | 94-59-7 | C10H10O2 |
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2. Where does Safrole originate from in the production process?
In the production process, the compound safrole is often extracted from natural plants, especially from the roots and stems of the star anise tree, a plant native to Asia. In addition, safrole can also be found in some plants such as pepper, rhubarb, and some other herbs. This extraction process typically involves harvesting parts of the plant, then using methods such as distillation or pressing to obtain the essential oil containing safrole.
In industry, safrole can also be synthesized from other chemical raw materials. This synthesis process usually takes place in chemical plants, where chemical reactions are carried out to create safrole from basic compounds like benzene or allyl bromide. However, the production of safrole from natural sources is still more common due to environmental benefits and safety in the production process.

3. Industries that use Safrole in production
Many industries in the current industrial sector use safrole as a key component in their production processes. One of the prominent industries is the food processing industry, where safrole is used as a natural flavoring in the production of soft drinks, confectionery, and alcoholic beverages. The characteristic aromatic property of safrole enhances the flavor and creates appeal for the product.
Besides the food industry, safrole is also present in the chemical industry. Here, it is used as a raw material to produce other organic compounds, such as pesticides, antibacterial agents, and therapeutic drugs. The diversity in the application of safrole makes it an important compound, but it also places high demands on safety for workers exposed to this chemical during production.
The perfume and cosmetics manufacturing industry also cannot do without safrole, as this compound provides a distinctive fragrance and has long-lasting scent retention capabilities. Many high-end perfume products use safrole as a primary ingredient to create a unique scent, increasing the product’s value.
4. How does Safrole affect workers?
Exposure to safrole can cause many negative impacts on the health of workers. Studies have shown that this compound has the potential to be toxic to the liver and kidneys, leading to the risk of serious diseases if workers are exposed continuously or for long periods. Feelings of fatigue, nausea, and headaches are common symptoms that workers may experience when inhaling or coming into contact with safrole.
Furthermore, safrole is also considered a potential risk factor for causing cancer. Animal studies show that safrole can cause the development of tumors, especially in the liver. This makes protecting workers’ health urgent, especially in manufacturing plants that use this chemical.
Additionally, safrole can cause irritation to the skin and respiratory system, especially upon direct contact with the liquid form of the chemical. People working in environments with high concentrations of safrole may experience respiratory problems such as coughing, shortness of breath, and bronchitis.
5. Permissible safe concentration of Safrole for human exposure
To ensure safety for workers in environments where safrole is used, determining the permissible concentration of this compound is extremely important. Organizations and regulatory bodies, such as the World Health Organization (WHO) and the U.S. Environmental Protection Agency (EPA), have researched and issued standards for safe safrole concentrations in the air.
According to current regulations, the permissible concentration of safrole in the workplace typically ranges from 0.1 to 0.5 mg/m³ of air. This concentration is determined based on studies of the toxicity and health effects of safrole on humans. Adhering to these standards not only helps minimize health risks for workers but also protects the surrounding environment.

On a basic level, if working in an industrial environment, it is important to adhere to safety standards and limit exposure to Safrole. Organizations like the Occupational Safety and Health Administration (OSHA) in the United States provide guidelines and safety principles to protect workers from the negative impacts of chemical substances.
6. Measures to minimize the impact of Safrole on workers’ health
To minimize the impact of safrole on workers’ health, a series of safety measures and effective management practices must be implemented in the workplace. First and foremost, educating and raising awareness about the health risks associated with safrole is extremely important. Workers need to be fully informed about how to recognize and handle situations that may arise from exposure to this compound.
One of the key measures is to ensure adequate ventilation in work areas where safrole is used. A good ventilation system helps reduce the concentration of safrole in the air, thereby limiting the possibility of inhaling the compound. In addition, the use of personal protective equipment such as masks, gloves, safety glasses, and protective clothing is also essential. This equipment not only protects workers from direct contact with safrole but also minimizes the risk of related diseases.
Besides, factories need to implement periodic monitoring of safrole concentrations in the air to promptly detect and address situations where the concentration exceeds the permissible limit. This can be done through specialized measuring devices, which help continuously monitor the level of safrole in the work environment.
Finally, organizing regular training programs for workers on chemical safety and the use of personal protective equipment is also a crucial factor. Training helps workers understand safety procedures, thereby protecting themselves and their colleagues during work. All these measures will contribute to creating a safer working environment, protecting workers’ health from the negative effects of safrole.
Occupational safety training: Workers need to be trained and educated on the risks and safety measures when working with this type of chemical. This training should be provided periodically and regularly to ensure understanding and proper compliance with safety rules.
Periodically organize occupational environment monitoring in factories and enterprises, collecting and analyzing factors harmful to workers, thereby adjusting to reduce the hazard level to prevent occupational diseases for them.
7. National Occupational Environment Monitoring Center
Nam Viet’s Occupational Environment Monitoring Center is a professional unit specializing in the supervision and measurement of occupational environment quality across all provinces in Vietnam. With a team of experienced monitoring specialists, the center uses modern measuring equipment, ensuring accuracy and reliability.
REGISTER FOR OCCUPATIONAL ENVIRONMENT MONITORING SERVICE
In addition to providing monitoring services, the center also supports clients in planning, handling, and tracking occupational environment issues. With the motto “the customer is the center,” the center focuses on customer satisfaction, meets all customer needs, and commits to providing the best solutions for businesses.
With investment in techniques, technology, and human resources, Nam Viet’s monitoring center has been and is becoming one of the reputable units in the field of occupational environment monitoring in Ho Chi Minh City with the following objectives:
- We always value our brand reputation and the quality of our products and services.
- We provide our customers with the best and most suitable options possible.
- Along with a team of experienced and specialized Masters and Engineers, we wish to protect the environment and benefit businesses.

- With the Nam Viet Environmental Monitoring team, your company will receive professional service from experts in the monitoring field. At the same time, you will get the best cost incentives.
8. Quotation for occupational environment monitoring
To help businesses carry out occupational environment monitoring professionally and effectively, Nam Viet provides our customers with a quality and reasonably priced quotation table for occupational environment monitoring services.
- Our monitoring quotation table provides detailed information on the prices of the monitoring services we offer. This includes costs related to travel, measurement, analysis, and reporting of results. Customers can be completely assured of the accuracy and reliability of the monitoring result reports we provide.
- We are committed to always offering the most competitive and reasonable prices on the market, and we are also always ready to provide consultation and answer any questions about our monitoring services quickly and professionally.
- With Nam Viet’s quotation table, customers can easily choose service packages that suit their needs. We are committed to bringing our customers the highest satisfaction with professional quality service.

