Acetic anhydride (C4H6O3) is a common chemical in industrial production, but do you know what effects it can have on workers’ health? This article will explore the impact of acetic anhydride on the respiratory system, skin, eyes, and nervous system, while also providing safety measures for the work environment.
1. What is Acetic anhydride?
Acetic anhydride is a chemical compound with the molecular formula C4H6O3. Widely known in the chemical industry, acetic anhydride is a colorless, volatile liquid with a pungent odor and strong irritant properties. It is a derivative of acetic acid (CH3COOH), with its main characteristic being two acetyl groups linked together, which creates its unique properties.
| No. | Chemical Name in Vietnamese | Chemical Name in English | HS Code | CAS Number | Chemical Formula |
| 1. | Axetic anhydrit | Acetic anhydride | 29152400 | 108-24-7 | C4H6O3 |
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2. Where does Acetic anhydride originate from in the production process?
This compound primarily originates from production processes in the chemical industry, especially in the manufacturing of acetic acid derivatives. During synthesis, acetic anhydride is created through the reaction of acetic acid with strong chemical agents like ketene. This reaction creates a harsh environment that requires close monitoring to control emissions and hazardous waste, ensuring worker safety.
Additionally, in the cellulose acetate production industry – a common material in products like photographic film, artificial fibers, and coatings – acetic anhydride is a key component and is often used in large quantities. This production process not only creates acetic anhydride but also generates other additives and by-products, increasing the risk of chemical dispersal into the surrounding environment if not managed strictly.
In pharmaceutical and agricultural chemical manufacturing plants, acetic anhydride is also an important intermediate. It participates in many chemical reactions to create final products such as medicines and pesticides.

3. Industries that use Acetic anhydride in production
This is an important chemical in many different industries, especially in the chemical, pharmaceutical, plastics, and synthetic fiber manufacturing sectors. In the chemical industry, acetic anhydride plays a crucial role in the synthesis of many organic compounds. It is often used to produce acetate, a key component in industrial and consumer products such as solvents, paints, and adhesives.
The pharmaceutical industry is another major field that uses acetic anhydride, particularly in the production of painkillers and anti-inflammatory drugs. This chemical participates in the reaction to form acetyl, an important chemical group in the structure of many types of medication. The use of acetic anhydride in pharmaceutical production requires strict procedures and a safe working environment to ensure product quality and protect workers’ health.
In the plastics and synthetic fiber industry, acetic anhydride is a main component in the production of cellulose acetate. This is the raw material for products such as film, synthetic fibers, and various coatings, providing high durability and flexibility. This manufacturing sector often uses acetic anhydride on a large scale, thus requiring effective environmental protection and occupational safety measures to avoid the risk of chemical exposure.
Furthermore, acetic anhydride is also used in the agricultural and food industries. In agriculture, it is a component of some types of pesticides and plant protection chemicals.
4. How does Acetic anhydride affect workers?
Acetic anhydride can cause many negative health effects for workers in environments where this chemical is used. Upon contact with acetic anhydride, workers may experience immediate irritation symptoms. These symptoms include burning, redness, and itching of the exposed skin, as well as eye discomfort. If acetic anhydride vapor enters the respiratory tract, workers may suffer from coughing, difficulty breathing, and even chest pain.
One of the more serious impacts of acetic anhydride is the risk of long-term damage to the respiratory system. Prolonged or high-concentration exposure can lead to chemical pneumonitis, causing chronic respiratory problems. Furthermore, inhaling acetic anhydride vapor can affect the nervous system, leading to symptoms such as dizziness, headaches, and fatigue.
In addition to physical symptoms, acetic anhydride can also negatively impact the mental health of workers. Anxiety about workplace safety and the potential risks from exposure to toxic chemicals can create psychological stress. This can affect work performance and the quality of life of the workers.
5. Permissible safe concentration of Acetic anhydride for human exposure
The permissible safe concentration of acetic anhydride for human exposure is a critical factor in protecting the health of workers in environments where this chemical is used. Health and occupational safety agencies have established maximum permissible concentration limits to minimize health risks from exposure to acetic anhydride.
According to regulations from organizations such as OSHA (Occupational Safety and Health Administration) in the United States, the maximum permissible exposure limit for acetic anhydride in the workplace air is 5 ppm (parts per million) over an 8-hour workday. This means that workers should not be exposed to concentrations exceeding 5 ppm for extended periods. These regulations are based on studies of the health effects of acetic anhydride and are intended to protect workers from potential negative impacts.

On a basic level, when working in an industrial environment, it is important to adhere to safety standards and limit exposure to Acetic anhydride. Organizations like the Occupational Safety and Health Administration (OSHA) in the United States provide guidelines and safety principles to protect workers from the negative impacts of chemical substances.
6. Measures to minimize the impact of Acetic anhydride on workers’ health
To minimize the impact of acetic anhydride on workers’ health, protective measures and chemical safety management are extremely necessary. First and foremost, training employees on occupational safety and how to handle acetic anhydride is a top priority. Workers need to be equipped with knowledge about the chemical’s properties, symptoms of exposure, and emergency procedures in case of an incident. This understanding not only helps them protect themselves but also raises collective awareness in implementing safety measures.
Secondly, the use of personal protective equipment (PPE) is crucial. Workers must fully use equipment such as respirators, safety goggles, gloves, and appropriate protective clothing when working with acetic anhydride. This equipment creates a protective barrier, preventing the chemical from coming into direct contact with the skin and respiratory system, thereby minimizing the risk of related illnesses.
In addition, improving the ventilation system in the work area is also one of the effective measures to reduce the concentration of acetic anhydride in the air. Factories need to install ventilation devices, exhaust fans, and air filtration systems to maintain fresh air and minimize the accumulation of the chemical in the work environment. This not only helps protect workers’ health but also improves work efficiency.
Finally, businesses should also regularly check and monitor the concentration of acetic anhydride in the air to ensure that it remains within safe limits. Safety procedures such as periodic equipment checks, ventilation system maintenance, and chemical waste control are also essential for maintaining a safe working environment.
Occupational safety and health training: Workers need to be trained and educated on the risks and safety measures when working with this type of chemical. This training should be provided periodically and regularly to ensure understanding and proper adherence to safety rules.
Periodically organize occupational environment monitoring in factories and enterprises, collecting and analyzing factors harmful to workers, thereby adjusting to reduce the hazard level to prevent occupational diseases for them.
7. National Occupational Environment Monitoring Center
Nam Viet’s Occupational Environment Monitoring Center is a professional unit for monitoring and measuring the quality of the working environment across all provinces in Vietnam. With a team of experienced monitoring specialists, the center uses modern measuring equipment, ensuring accuracy and reliability.
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In addition to providing monitoring services, the center also assists clients in planning, handling, and tracking issues related to the occupational environment. With the motto “the customer is the center,” the center is concerned with customer satisfaction, meets all customer needs, and is committed to providing the best solutions for businesses.
With investment in techniques, technology, and human resources, Nam Viet’s monitoring center has become one of the reputable units in the field of occupational environment monitoring in Ho Chi Minh City with the following objectives:
- We always value our brand reputation and the quality of our products and services.
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- Along with a team of Masters and Engineers with extensive experience and expertise, we aim to protect the environment and benefit businesses.

- By choosing the Nam Viet Environmental Monitoring team, your company will receive professional service from experts in the monitoring field, along with the best cost incentives.
8. Quotation for Occupational Environment Monitoring
To help businesses conduct occupational environment monitoring in a professional and effective manner, Nam Viet provides our clients with a quality and reasonably priced quotation table for occupational environment monitoring services.
- Our monitoring quotation table provides detailed information on the pricing of the monitoring services we offer. This includes costs related to travel, measurement, analysis, and reporting of results. Our clients can be completely assured of the accuracy and reliability of the monitoring result reports we provide.
- We are committed to always offering the most competitive and reasonable prices on the market, and we are also always ready to provide consultation and answer any questions about our monitoring services quickly and professionally.
- With Nam Viet’s quotation table, clients can easily choose service packages that suit their needs. We are committed to bringing our clients the highest satisfaction with professional quality service.

